Biomarkers for Success

Hanlon, Colleen A.; Dowdle, Logan T.; Jones, Jennifer

doi:10.1016/bs.irn.2016.06.006

Cited by 23 publications

(10 citation statements)

References 159 publications

(229 reference statements)

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“…Amplifying executive control circuitry is certainly a very reasonable target and has been the primary target of choice in most TMS studies in substance dependent populations (reviews:(Barr et al, 2011; Bellamoli et al, 2014; Gorelick et al, 2014; Wing et al, 2013)). From a craving and relapse perspective however, the majority of clinical neuroimaging studies demonstrate that the OFC, anterior cingulate cortex, orbitofrontal cortex, and even the insula are regions that are more directly involved in craving, and resting state connectivity among these regions is related to relapse(Camchong et al, 2014; Garavan et al, 2000; Hanlon et al, 2016a; McHugh et al, 2014; Schacht et al, 2013; Sutherland et al, 2012). Consequently, applying an LTD-like dampening strategy to the MPFC might be an equally or even more efficient means of reaching a clinically-meaningful endpoint.…”

Section: Discussionmentioning

confidence: 99%

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Left frontal pole theta burst stimulation decreases orbitofrontal and insula activity in cocaine users and alcohol users

Hanlon

Dowdle

Correia

et al. 2017

Drug and Alcohol Dependence

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Background Preclinical research has demonstrated a causal relationship between medial prefrontal cortex activity and cocaine self-administration. As a step towards translating those data to a neural circuit-based intervention for patients, this study sought to determine if continuous theta burst stimulation (cTBS) to the left frontal pole (FP), would attenuate frontal-striatal activity in two substance-dependent populations. Methods Forty-nine substance dependent individuals (25 cocaine, 24 alcohol) completed a single-blind, sham-controlled, crossover study wherein they received 6 trains of real or sham cTBS (110% resting motor threshold, FP1) each visit. Baseline evoked BOLD signal was measured immediately before and after real and sham cTBS (interleaved TMS/BOLD imaging: single pulses to left FP; scalp-to-cortex distance covariate, FWE correction p<0.05) Results Among cocaine users, real cTBS significantly decreased evoked BOLD signal in the caudate, accumbens, anterior cingulate, orbitofrontal (OFC) and parietal cortex relative to sham cTBS. Among alcohol users, real cTBS significantly decreased evoked BOLD signal in left OFC, insula, and lateral sensorimotor cortex. There was no significant difference between the groups. Conclusions These data suggest that 6 trains of left FP cTBS delivered in a single day decreases TMS-evoked BOLD signal in the OFC and several cortical nodes which regulate salience and are typically activated by drug cues. The reliability of this pattern across cocaine- and alcohol-dependent individuals suggests that cTBS may be an effective tool to dampen neural circuits typically engaged by salient drug cues. Multiday studies are required to determine it this has a sustainable effect on the brain or drug use behavior.

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Section: Discussionmentioning

confidence: 99%

“…The average distance from the participant-specific placement of FP1 to the nearest cortex (Cocaine: 18.5 +/− 5.8; Alcohol: 16.37 mm +/− 3.18) was not significantly different between the groups. As in previous studies (Hanlon et al, 2016), all analyses for Interleaved TMS/BOLD were done with these distances as covariates.…”

Section: Methodsmentioning

confidence: 99%

Left frontal pole theta burst stimulation decreases orbitofrontal and insula activity in cocaine users and alcohol users

Hanlon

Dowdle

Correia

et al. 2017

Drug and Alcohol Dependence

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“…Support for craving as a key treatment target for SUD comes from multiple behavioral, imaging, pharmacology, and genetics studies Garrison and Potenza, 2014;Haass-Koffler et al, 2014;Sinha, 2009;Tiffany and Wray, 2012). Selfreported craving, however, is often very subjective and is not as closely related to relapse as biological markers of cue-sensitivity (for review see: Hanlon et al, 2016a;). This may be because craving as a construct requires that participants have insight into something that is a fairly complex psychological phenomenon.…”

Section: Cue-reactivity and Self-reported Cravingmentioning

confidence: 99%

Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Ekhtiari

Tavakoli

Addolorato

et al. 2019

Neuroscience & Biobehavioral Reviews

237

189

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There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments for mental health disorders that share overlapping pathology with SUDs. As with any emerging field, enthusiasm must be tempered by reason; lessons learned from the past should be prudently applied to future therapies. Here, an international ensemble of experts provides an overview of the state of transcranial-electrical (tES) and transcranial-magnetic (TMS) stimulation applied in SUDs. This consensus paper provides a systematic literature review on published data-emphasizing the heterogeneity of methods and outcome measures while suggesting strategies to help bridge knowledge gaps. The goal of this effort is to provide the community with guidelines for best practices in tES/TMS SUD research. We hope this will accelerate the speed at which the community translates basic neuroscience into advanced neuromodulation tools for clinical practice in addiction medicine.

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“…This might explain why the abusers are hardly able to control the craving and consumption of drugs. In general, the dysfunction of dopamine pathway plays a central role in drug addiction and this notion has inspired the development of neurobiological treatments including acupuncture (Lee et al, 2009), pharmacotherapies (Lu et al, 2009), neurosurgical operations (Stelten et al, 2008), and brain stimulations (Müller et al, 2013; Hanlon et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effects of Non-invasive Brain Stimulation on Stimulant Craving in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-Analysis

Sun

2019

Front. Neurosci.

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Dopamine system plays a pivotal role in specific kinds of substance use disorders (SUD, i. e., cocaine and methamphetamine use disorders). Many studies addressed whether dopamine-involved craving could be alleviated by non-invasive brain stimulation (NIBS) techniques. Nevertheless, the outcomes were highly inconsistent and the stimulating parameters were highly variable. In the current study, we ran a meta-analysis to identify an overall effect size of NIBS and try to find stimulating parameters of special note. We primarily find 2,530 unduplicated studies in PubMed, Psychology and Behavioral Sciences Collection, PsycARTICLES, PsycINFO, and Google Scholar database involving “Cocaine”/“Amphetamine”/“Methamphetamine” binded with “TMS”/“tDCS”/“non-invasive stimulation” in either field. After visual screening, 26 studies remained. While 16 studies were further excluded due to the lack of data, invalid craving scoring or the absence of sham condition. At last, 16 units of analysis in 12 eligible studies were coded and forwarded to a random-effect analysis. The results showed a large positive main effect of stimulation (Hedge's g = 1.116, CI = [0.597, 1.634]). Further subgroup analysis found that only high-frequency repetitive transcranial magnetic stimulation (rTMS) could elicit a significant decrease in craving, while the outcome of low-frequency stimulation was relatively controversial. Moreover, univariate meta regression revealed that the number of pulses per session could impose negative moderation toward the intervention. No significant moderation effect was found in types of abuse, overall days of stimulation and other variables of stimulating protocol. In conclusion, this meta-analysis offered a persuasive evidence for the feasibility of using NIBS to remit substance addictive behavior directly based on dopamine system. We also give clear methodological guidance that researchers are expected to use high-frequency, sufficiently segmented rTMS to improve the efficacy in future treatments.

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Biomarkers for Success

Cited by 23 publications

References 159 publications

Left frontal pole theta burst stimulation decreases orbitofrontal and insula activity in cocaine users and alcohol users

Left frontal pole theta burst stimulation decreases orbitofrontal and insula activity in cocaine users and alcohol users

Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Effects of Non-invasive Brain Stimulation on Stimulant Craving in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-Analysis

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