Biomarkers for systemic lupus erythematosus – a focus on organ damage

Ding, Huihua; Shen, Yiwei; Hong, Soon-Min; Xiang, Chunyan; Shen, Nan

doi:10.1080/1744666x.2023.2260098

Cited by 5 publications

(4 citation statements)

References 220 publications

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“…Prognosis [213] Vascular injury (+) (≥25% subintimal narrowing of the lumen) Prognosis [213] AaA: Anti-actin antibody; ANCA: Anti-neutrophil cytoplasmic antibody; Ang2: Angiopoietin 2; Angptl4: Angiopoietin-like 4; Anti-C1q: Anti-complement component 1q; Anti-CRP: Anti-C-reactive protein; Anti-dsDNA: Anti-double-stranded deoxyribonucleic acid; Anti-ENO-1: Anti-Enolase Several reasons may account for the fact that none of the discussed biomarkers has reached the bedside. There are challenges in both the discovery and clinical phase of biomarker validation [161]. During the discovery phases a major weight is placed on the formulation of clinically relevant questions and the identification of markers closely linked to the pathogenesis of LN, while less effort is made to consider the clinical and pathogenetic heterogeneity of LN in long prospective studies.…”

Section: Discussionmentioning

confidence: 99%

Lupus Nephritis Biomarkers: A Critical Review

Alduraibi,

Tsokos

2024

IJMS

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Lupus nephritis (LN), a major complication in individuals diagnosed with systemic lupus erythematosus, substantially increases morbidity and mortality. Despite marked improvements in the survival of patients with severe LN over the past 50 years, complete clinical remission after immunosuppressive therapy is achieved in only half of the patients. Therefore, timely detection of LN is vital for initiating prompt therapeutic interventions and improving patient outcomes. Biomarkers have emerged as valuable tools for LN detection and monitoring; however, the complex role of these biomarkers in LN pathogenesis remains unclear. Renal biopsy remains the gold standard for the identification of the histological phenotypes of LN and guides disease management. However, the molecular pathophysiology of specific renal lesions remains poorly understood. In this review, we provide a critical, up-to-date overview of the latest developments in the field of LN biomarkers.

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Section: Discussionmentioning

confidence: 99%

Lupus Nephritis Biomarkers: A Critical Review

Alduraibi,

Tsokos

2024

IJMS

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“…Next, Ding H. et al. note the potential of using biomarkers in the development of precision medicine in SLE ( 65 , 66 ). We encourage the concentration of future efforts towards the deepening of research in the field.…”

Section: Pathophysiological Mechanisms Of Lung Damagementioning

confidence: 99%

Undercover lung damage in pediatrics - a hot spot in morbidity caused by collagenoses

Lupu,

Sasaran,

Jechel

et al. 2024

Front. Immunol.

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Connective tissue represents the support matrix and the connection between tissues and organs. In its composition, collagen, the major structural protein, is the main component of the skin, bones, tendons and ligaments. Especially at the pediatric age, its damage in the context of pathologies such as systemic lupus erythematosus, scleroderma or dermatomyositis can have a significant negative impact on the development and optimal functioning of the body. The consequences can extend to various structures (e.g., joints, skin, eyes, lungs, heart, kidneys). Of these, we retain and reveal later in our manuscript, mainly the respiratory involvement. Manifested in various forms that can damage the chest wall, pleura, interstitium or vascularization, lung damage in pediatric systemic inflammatory diseases is underdeveloped in the literature compared to that described in adults. Under the threat of severe evolution, sometimes rapidly progressive and leading to death, it is necessary to increase the popularization of information aimed at physiopathological triggering and maintenance mechanisms, diagnostic means, and therapeutic directions among medical specialists. In addition, we emphasize the need for interdisciplinary collaboration, especially between pediatricians, rheumatologists, infectious disease specialists, pulmonologists, and immunologists. Through our narrative review we aimed to bring up to date, in a concise and easy to assimilate, general principles regarding the pulmonary impact of collagenoses using the most recent articles published in international libraries, duplicated by previous articles, of reference for the targeted pathologies.

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“…Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease known for its unpredictable course and diverse clinical manifestations [ 1 , 2 ]. It primarily affects women of childbearing age globally, presenting a significant public health challenge [ 2 , 3 ]. SLE can involve multiple organ systems, with symptoms ranging from mild skin lesions to severe renal damage [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease known for its unpredictable course and diverse clinical manifestations [1,2]. It primarily affects Nutrients 2024, 16,1974 2 of 13 women of childbearing age globally, presenting a significant public health challenge [2,3]. SLE can involve multiple organ systems, with symptoms ranging from mild skin lesions to severe renal damage [4].…”

Section: Introductionmentioning

confidence: 99%

Association between Unsaturated Fatty Acid-Type Diet and Systemic Lupus Erythematosus: A Systematic Review with Meta-Analyses

Wang,

Huang

et al. 2024

Nutrients

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Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder that affects multiple organ systems, with a higher prevalence among women in their reproductive years. The disease’s multifactorial etiology involves genetic, environmental, and hormonal components. Recent studies have highlighted the potential impact of dietary factors, particularly unsaturated fatty acids, on the modulation of SLE due to their anti-inflammatory properties. This meta-analysis aims to evaluate the association between unsaturated fatty acid consumption and the risk, progression, and clinical manifestations of SLE, providing evidence-based guidance for dietary management. Methods: We conducted a comprehensive search across major medical databases up to January 2024, focusing on studies that examined the intake of unsaturated fatty acids and the impact of such intake on SLE. Using the PICOS (population, intervention, comparator, outcomes, study design) framework, we included randomized controlled trials and case–control studies, assessing outcomes such as SLE activity, measured by SLE Disease Activity Index (SLEDAI) or the British Isles Lupus Assessment Group (BILAG) index, inflammation biomarkers. Studies were analyzed using either a fixed- or random-effects model based on heterogeneity (I2 statistic), with sensitivity analyses performed to assess the robustness of the findings. Results: Our search included 10 studies, encompassing a wide variety of designs and populations. The meta-analysis showed that a diet rich in unsaturated fatty acids is significantly associated with a reduction in SLEDAI scores (pooled SMD) of −0.36, 95% CI: −0.61 to −0.11, p = 0.007, indicating a beneficial effect on disease activity. Additionally, we found that unsaturated fatty acid intake has a significant impact on HDL levels, suggesting a positive effect on lipid profiles. However, no significant effects were observed on levels of the inflammatory marker IL-6 or other lipid components (LDL and cholesterol). With minimal heterogeneity among studies (I2 ≤ 15%), sensitivity analysis confirmed the stability and reliability of these results, highlighting the potential role of unsaturated fatty acids in SLE management. Conclusions: This meta-analysis suggests that dietary intake of unsaturated fatty acids may play a positive role in reducing SLE activity and may significantly affect HDL levels without having significant effects on inflammation markers or other lipid profiles. These findings support the inclusion of unsaturated fatty acids in the dietary management of SLE patients, although further research is required to refine dietary recommendations and explore the mechanisms underlying these associations.

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Biomarkers for systemic lupus erythematosus – a focus on organ damage

Cited by 5 publications

References 220 publications

Lupus Nephritis Biomarkers: A Critical Review

Lupus Nephritis Biomarkers: A Critical Review

Undercover lung damage in pediatrics - a hot spot in morbidity caused by collagenoses

Association between Unsaturated Fatty Acid-Type Diet and Systemic Lupus Erythematosus: A Systematic Review with Meta-Analyses

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