Biomarkers in alopecia Areata: A systematic review and meta-analysis.

Zaaroura, Hiba; Gilding, Anthony J.; Sibbald, Cathryn

doi:10.1016/j.autrev.2023.103339

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…30 systematic review and meta-analysis by Zaaroura et al, they screened 1714 studies and found that interleukin 6 (IL6) and CRP are considered biomarkers for AA. 31 As previously indicated from our results vitamin D decreases and CRP increases in AA patients this relationship between these two parameters can be explained by the important mechanism that vitamin D hailed as a pro-hormone, possesses a remarkable attribute of being able to combat inflammation. The comprehensive examination conducted by our study suggests that this potent anti-inflammatory capacity can be attributed to the hormonal influence that vitamin D exerts on immune cells expressing the VDR.…”

Section: Discussionsupporting

confidence: 77%

“…The same result was noted by Wang et al., who found that AA patients suffer from increased levels of cardiac troponin I and CRP 30 . systematic review and meta‐analysis by Zaaroura et al., they screened 1714 studies and found that interleukin 6 (IL6) and CRP are considered biomarkers for AA 31 …”

Section: Discussionsupporting

confidence: 54%

“… 30 systematic review and meta‐analysis by Zaaroura et al., they screened 1714 studies and found that interleukin 6 (IL6) and CRP are considered biomarkers for AA. 31 …”

Section: Discussionmentioning

confidence: 99%

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C‐reactive protein as a novel biomarker for vitamin D deficiency in alopecia areata

AbdElneam,

Al‐Dhubaibi,

Bahaj

et al. 2024

Skin Research and Technology

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BackgroundAlopecia areata (AA) is an autoimmune condition characterized by sudden and unpredictable hair loss, with a lifetime incidence of 2%. AA can be divided into three categories: patchy alopecia, alopecia totalis, and alopecia universalis. It can affect a person's psychological health and overall quality of life. Elevated C‐reactive protein (CRP) levels in the liver may indicate an inflammatory response in autoimmune diseases. Vitamin D, essential for immune system control and skin health, may be related to AA. Hair follicles contain vitamin D receptors, which control immunological responses in the skin. However, no study has found a relationship between CRP and vitamin D in AA patients in our region.Subjects and MethodsAn analytical cross‐sectional study with a case‐control design research investigation of 82 AA patients and 81 healthy controls was carried out. Both groups’ medical histories were taken. Biochemical analysis was done for both groups as well as the serum vitamin D levels, and CRP. Genetic analysis for CDX2 rs11568820 variant detected by PCR (T‐ARMS‐PCR) method and vitamin D receptor (VDR) gene expression measured by real‐time PCR analysis for both patients and healthy subjects.ResultsCRP levels are higher in AA patients, AA patients with G/G genotypes exhibited higher concentrations of CRP when compared to those with A/A and A/G genotypes while patients with A/A genotypes have higher levels of Serum vitamin D as compared to the A/G and G/G genotypes. G allele was more abundant in AA patients. VDR gene expression was lower in AA compared to control and lower in ophiasis compared to localized and multiple patchy AA. An important inverse linear correlation was observed between vitamin D and CRP levels in ophiasis AA.ConclusionCRP concentrations were found to be elevated in AA patients. The considerable accuracy of CRP in the diagnosis of AA is substantiated by a statistically significant al. A noteworthy inverse linear association was observed between serum vitamin D and CRP concentrations in ophiasis AA.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 54%

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C‐reactive protein as a novel biomarker for vitamin D deficiency in alopecia areata

AbdElneam,

Al‐Dhubaibi,

Bahaj

et al. 2024

Skin Research and Technology

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“…A recent meta-analysis found that serum interleukin-6 (IL-6) and C-reactive protein (CRP) levels are significantly increased in patients with AA, compared to healthy controls, whilst serum vitamin D levels are significantly decreased [ 19 ]. More than half of Greek and Italian dermatologists prescribe indicators of inflammation (57.9%) such as CRP, while dosage of serum IL-6 is not usually prescribed.…”

Section: Discussionmentioning

confidence: 99%

Current Diagnostic and Therapeutic Practices in Alopecia Areata in Two Mediterranean Countries: A Survey-Based Study

Starace,

Pampaloni,

Lazaridou

et al. 2024

Dermatol Ther (Heidelb)

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Introduction Alopecia areata (AA) affects approximately 2% of the general population and is associated with significant psychosocial morbidity and poor health-related quality of life. Despite the high incidence of the disease the available clinical practice guidelines to help clinicians and improve patients’ care are very poor and of a low methodological quality, as compared to other high-burden dermatoses. The aim of this survey is to capture the current clinical practice in AA management, as performed by dermatologists, in two Mediterranean countries to identify potential disparities and gaps in diagnosis and treatment. Methods A 50-item questionnaire was created in the English language and then translated into Greek and Italian language and sent to the Greek and Italian dermatologists via email. Results A total of 490 dermatologists from Italy and 234 from Greece participated in the survey. The diagnosis of AA is usually based on history and clinical examination, supported by trichoscopy. The rate of use of severity scores and scales to evaluate impact on quality of life by dermatologists was low. Treatment of patchy AA, in both adult and pediatric populations, is based on use of topical steroids as first-line treatment. Results on special site involvement (eyebrows, beard, and ophiasis), chronic cases, and the pediatric population highlight extreme heterogeneity in treatment approach. Conclusions Our results highlight that management of AA, in terms of diagnosis and treatment, is still challenging. Supplementary Information The online version contains supplementary material available at 10.1007/s13555-024-01141-z.

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“…These findings underscore the multifaceted nature of AA, where not only inflammatory markers like lipocalin-2 but also insulin-related and metabolic factors contribute to the intricate web of interactions that influence the development and progression of this autoimmune hair loss disorder. A recent meta-analysis indicated significant associations for TNF-α, IL7a, IFN-γ, C-reactive protein, IL-6, and vitamin D with AA [29]. The increase in these markers suggest an inflammatory milieu, implicating these factors in the autoimmune attack on hair follicles.…”

Section: Alopecia Areatamentioning

confidence: 99%

Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies

Tan,

Podwojniak,

Parikh

et al. 2024

CIMB

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The evolution of personalized medicine in dermatology signifies a transformative shift towards individualized treatments, driven by the integration of biomarkers. These molecular indicators serve beyond diagnostics, offering insights into disease staging, prognosis, and therapeutic monitoring. Specific criteria guide biomarker selection, ensuring attributes like specificity, sensitivity, cost feasibility, stability, rapid detection, and reproducibility. This literature review, based on data from PubMed, SCOPUS, and Web of Science, explores biomarkers in Hidradenitis Suppurativa (HS), Psoriasis, Atopic Dermatitis (AD), Alopecia Areata (AA), Vitiligo, and Chronic Spontaneous Urticaria (CSU). In HS, TNF-α, IL-1β, and MMPs serve as biomarkers, influencing targeted therapies like adalimumab and anakinra. Psoriasis involves biomarkers such as TNF-α, IL-23, and HLA genes, shaping treatments like IL23 and IL17 inhibitors. AD biomarkers include ECP, IL-4, IL-13, guiding therapies like dupilumab and tralokinumab. For AA, lipocalin-2, cytokines, and genetic polymorphisms inform JAK inhibitors’ use. Vitiligo biomarkers range from cytokines to genetic markers like TYR, TYRP1, guiding treatments like JAK inhibitors. CSU biomarkers encompass IgE, cytokines, and autologous serum tests, influencing therapies like omalizumab and cyclosporine. Comparing conditions, common proinflammatory markers reveal limited specificity. While some biomarkers aid diagnosis and standard treatments, others hold more scientific than clinical value. Precision medicine, driven by biomarkers, has shown success in skin malignancies. Future directions involve AI-powered algorithms, nanotechnology, and multi-omics integration for personalized dermatological care.

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Biomarkers in alopecia Areata: A systematic review and meta-analysis.

Cited by 11 publications

References 38 publications

C‐reactive protein as a novel biomarker for vitamin D deficiency in alopecia areata

C‐reactive protein as a novel biomarker for vitamin D deficiency in alopecia areata

Current Diagnostic and Therapeutic Practices in Alopecia Areata in Two Mediterranean Countries: A Survey-Based Study

Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies

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