Biomarkers in breast cancer

Abstract

Breast cancer is a disease characterized by abnormal growth and development of nor mal breast tissue. When the growth and development of a normal cell no longer obey biological control mechanisms, tumour cells begin to appear. An understanding of normal biological processes relating to cell growth, such as the cell cycle, angiogenesis, and apoptosis, and of other abnormal processes, such as neo-plastic transformation, tumour progression, and metastasis, would aid not only in identifying tumour markers, but also in determining the best uses of these tumour markers for diagnosis and treatment of patients with cancer. Biomarkers are improving our understanding of the biology and management of breast cancer. Medicinski fakultet, Ni{, Srbija Klinika za onkologiju, Klini~ki centar »Ni{«, Ni{, SrbijaKratak sadr`aj: Rak dojke je bolest abnormalnog rasta i razvoja do tada normalnog tkiva dojke. Tumor ska }elija nastaje kada }elija vi{e ne prepoznaje biolo{ke kontrolne mehanizme. Za bolje razumevanje biologije tumora, }elijskog ciklusa, angiogeneze, apoptoze, neoplasti~ne transformacije, fenomena progresije i metastaziranja veoma su zna~ajni biomarkeri kao prognosti~ki i prediktivni faktori. Biomarkeri raka dojke imaju posebnu vrednost u proceni agresivnosti bolesti i ranoj detekciji progresije.Klju~ne re~i: biomarkeri, rak dojke, biolo{ki procesi