Biomarkers in chronic obstructive pulmonary disease patients for prediction of lung cancer development

Balla, Murali Mohan Sagar; Melwani, Pooja Kamal; Kumar, Amit; Pandey, Badri N.

doi:10.4103/jrcr.jrcr_28_18

Cited by 2 publications

(1 citation statement)

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“…Delayed diagnosis of HNSCC has been associated with poor prognosis with a 5-year median overall survival of 42% at stage IV in Indian patients [27]. With the evolving understanding of the molecular basis of human malignancies, there has been great interest in determining whether serum biomarkers might aid in early diagnosis and guide treatment decision for the cancer patients [28]. Heat shock proteins (HSPs), especially, HSP70, HSP27 and HSP90 have been known to be released in the extra-cellular environment in various solid tumors [29].…”

Section: Plos Onementioning

confidence: 99%

Diagnostic potential of serum HSP90 beta for HNSCC and its therapeutic prognosis after local hyperthermia therapy

Shetake,

Kumar,

Huilgol

et al. 2023

PLoS ONE

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The present pilot study aims to investigate the diagnostic and prognostic efficacy of serum HSP90 beta in Head and Neck Squamous Cell Carcinoma (HNSCC) patients subjected to localized hyperthermia therapy (HT). Serum levels of HSP90 beta were measured by ELISA and its diagnostic and prognostic efficacy was determined by receiver operating characteristic curve (ROC) analysis. HNSCC patients showed significantly (P<0.05) higher serum levels of HSP90 beta (65.6±13.08 ng/ml) compared to Healthy Controls (HC: 23.5±3.8 ng/ml). No significant difference was observed in serum HSP90 beta levels between complete responders (CR) and non-responders (NR) in the chemo-radiation therapy (CRT) cohort. However, in CRT+HT cohort, CR showed significantly (P = 0.02) lower serum HSP90 beta levels at 24 h after HT (25.6±9.04 ng/ml) compared to NR (130.5±34.2 ng/ml). Youden’s index values between HNSCC versus HC, CR versus NR (CRT) and CR versus NR (CRT+HT) were found to be 0.47, 0.45 and 0.80, respectively. Thus, alterations in the serum HSP90 beta after HT suggest its potential in prognosis of HT response in HNSCC patients. Elevated levels of HSP90 beta may serve as a promising diagnostic serum bio-marker for HNSCC. However, further validation in larger patient samples is needed for clinical translation of HSP90 beta as diagnostic and prognostic biomarker.

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Section: Plos Onementioning

confidence: 99%