Biomarkers in Kidney Transplantation

Jain, Shreepal; Jani, Alkesh

doi:10.1016/b978-0-12-803014-1.00008-x

Cited by 1 publication

(1 citation statement)

References 191 publications

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“…In individuals with DGF, the peak postoperative serum SCr concentration necessitating dialysis frequently occurred two to four days after transplantation. Urine NGAL and IL-18 were higher in individuals with DGF on the first posttransplant day (19,20) . Proteins with a low molecular mass:…”

Section: Increased Proteinsmentioning

confidence: 91%

New Markers for Cases with Acute Renal Injury: Review Article

Ahmed¹,

Bakre²,

Ahmed³

2023

The Egyptian Journal of Hospital Medicine

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Background: Acute kidney injury (AKI) is caused by ischemia, toxins, radiographic contrast, and microbial endotoxins, among others. It affects around 30% of intensive care unit (ICU) patients and is significantly more frequent in operated heart cases. The concentration of (sCr) does not alter until about 50% of renal function is gone, and it is dependent on muscular weight, age, gender, and drugs. The delay between damage and function loss jeopardizes a therapy chance and can be a proof to the increased death rate of the condition. Several of these novel indicators for AKI may have potential applications in anesthesia and critical care. A panel of kidney biomarkers may be standardized before and after major surgery. If raised, the anesthesiology should take further precautions to optimize patients in the surgical wards or ICU post-operatively to minimize additional toxic insults and commence additional therapy. Objective: The aim of the present review is to highlight on AKI indicators that have been established during the recent decade. Methods: A comprehensive search was conducted in 4 data bases [PubMed, Google Scholar, and Egyptian Knowledge Bank], with keywords "Acute Kidney Injury, Biological Markers OR Intensive Care AND Postoperative Care", in peerreviewed articles between May 2001 and March 2022. Boolean operators (AND, OR, NOT) had been used. These databases were searched for articles published in English. Documents written in a language other than English have been disregarded since no sources for interpretation were discovered. Dissertations, conversations, conference abstract papers, and anything other than the primary scientific investigations had been disqualified. Results: Initiating a KDIGO preventive bundle in high-risk cases identified by markers might lower the occurrence and development of AKI, but had no positive impact on patient-centered outcome. Conclusion: The strength of evidence limits the widespread use of markers to guide RRT initiation decisions. CCL14 is one of the newly identified markers of renal non-recovery.

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Section: Increased Proteinsmentioning

confidence: 91%