Biomarkers in Oral Fluids as Diagnostic Tool for Psoriasis

Jiménez, Constanza; Bordagaray, María José; Villarroel, José Luis; Flores, Tania; Benadof, Dafna; Fernández, Alejandra; Valenzuela, Fernando

doi:10.3390/life12040501

Cited by 9 publications

(9 citation statements)

References 68 publications

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“…Finding in vitro parameters that adequately correlate with stress and its reduction during psoriasis treatment is a much more difficult task. Currently, we can see only single publications confirming their importance [26,27]. These include the biomarkers presented also in this study.…”

Section: Discussionmentioning

confidence: 76%

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis

et al. 2023

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Background and objectives: In psoriatic patients, stress is the most common aggravating factor. Despite the use of quality-of-life assessment questionnaires, diagnosing stress in psoriatic patients is not a flawless procedure. This study aimed to assess the usefulness of potential stress biomarkers in saliva for monitoring the treatment of psoriasis. Materials and methods: A total of 104 adult patients with severe psoriasis were included and randomly treated via biological treatment or symptomatic therapy: 84 received biological treatment, with 20 formed a control group receiving symptomatic therapy. The administered biological treatment was adalimumab, whilst in controls calcipotriol/betamethasone dipropionate topical gel and emollients were used. Patients were monitored monthly with a dermatological examination and the dispensing of a biological drug. During each of the four visits, the severity of the disease was assessed (PASI, BSA, and DLQI), and a sample of the patient’s saliva was taken. In all the participants, the saliva concentrations of immunoglobulin A (sIgA), α-amylase (sAA), and chromogranin A (CgA) were measured. Results: The majority of patients in both the study and control groups achieved clinical improvement, though favoring the group receiving biological treatment. The concentration of sIgA in the saliva was constantly increasing in the study group during subsequent visits (Fr = 27.26; p < 0.001). Meanwhile, there were no statistically significant changes in the control group during the same follow-up period (Fr = 6.66; p = 0.084). Levels of sAA underwent statistically significant changes in both groups (Fr = 58.02; p < 0.001—study group and Fr = 13.74; p = 0.003—control group). In the study group, a steady, statistically significant increase in sAA was observed from the first to the third visit. In the study group, a downward trend in CgA concentration was observed. In the control group, no significant differences in the level of CgA were obtained. Conclusions: sIgA, sAA, and CgA are potential markers of the severity of psoriasis and the associated stress reaction. Based on the presented observations, only sIgA and CgA seem to be valuable biomarkers for monitoring the effectiveness of the systemic treatment of psoriasis.

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Section: Discussionmentioning

confidence: 76%

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis

et al. 2023

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“…Herein, we presented a unique and comprehensive study on SII and SIRI in patients with psoriasis treated with biological agents. Although a variety of biological agents have been developed to be used in the treatment of psoriasis, there is lack of biomarkers widely preferred to asses disease severity, psoriatic arthritis and comorbidities and to be used during the course of treatment of psoriasis with biological agents [ 5 , 19 – 21 ]. Our results will contribute to the literature on the use of SII and SIRI in the management of psoriasis patients with biological agents.…”

Section: Discussionmentioning

confidence: 99%

Effect of Treatment With Biologic Agents on the Novel Inflammatory Biomarkers Systemic Immune Inflammation Index and Systemic Inflammation Response Index for Psoriasis

Tamer,

Edek,

Aksakal

2024

Dermatol Pract Concept

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Introduction: Psoriasis is a chronic cutaneous disorder with underlying systemic inflammation. The systemic immune inflammation (SII) and systemic inflammation response indexes (SIRI) are novel biomarkers that indicate systemic inflammation. Objectives: We aimed to evaluate the effect of biological agent treatment on SII and SIRI in psoriasis patients. Methods: Between April 2019 and October 2022, SII and SIRI were retrospectively evaluated in patients with psoriasis before and three months after the initiation of biological agents. Results: This study included 220 patients, 101 females and 119 males. SIRI was significantly higher in male patients compared to females (P < 0.001). Although not statistically significant, SII and SIRI were higher in obese patients, patients with severe psoriasis, longer disease duration, nail involvement and patients who received previous biological agent treatment. SII was also higher in patients with hypertension, diabetes, hepatic steatosis, depression and coronary artery disease (P = 0.801, P = 0.752, P = 0.706, P = 0.079, P = 0.861, respectively), whereas SIRI was higher in patients with diabetes and depression (P = 0.263, P = 0.777, respectively). Both SII and SIRI statistically significantly decreased after treatment with adalimumab, infliximab, ixekizumab, secukinumab, ustekinumab and risankizumab. Conclusions: SII and SIRI may indicate the severity of psoriasis as well as SII may be associated with psoriatic arthritis, hypertension, hepatic steatosis and coronary artery disease in patients with psoriasis. There is no consensus on the biomarkers that can be used to create an optimized treatment strategy in psoriasis. Therefore, SII and SIRI may be helpful in making the choice of treatment and in the follow-up of patients with psoriasis treated with biological agents.

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“…Considering that the GCF is a non-invasive method and readily available biomarker source for systemic disease diagnosis [ 26 ], we evaluated if the detection of MMP-9 in the GCF serves as a biomarker of rosacea. Today, no ROC curve areas are available for the tear and serum and the GCF levels of MMP-9 in rosacea diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Dermal keratinocytes and fibroblasts synthesize MMPs in response to chronic exposure to several stimuli such as ultraviolet radiation and pro-inflammatory cytokines [ 24 , 25 ]. Among the different types of MMPs, MMP-2 and -9 have been implicated as participants in the pathogenesis of rosacea [ 26 , 27 ]. These MMPs belong to the gelatinase family and cooperatively participate in the degradation of gelatin and collagen type I [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

MMP-9 Levels in the Gingival Crevicular Fluid of Chilean Rosacea Patients

Fernández

Jiménez

Benadof

et al. 2022

IJMS

Self Cite

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Rosacea is a chronic inflammatory skin disease whose prevalence rates remain unknown in Chile. Laboratory benchmark testing for this disease is not useful, therefore, we aimed to evaluate the gingival crevicular fluid (GCF) levels of extracellular metalloproteinases (MMP)-2 and MMP-9 as novel rosacea biomarkers. We designed a cross-sectional study with a control group. Participants were systemically healthy adults (n = 20) and persons with rosacea (n = 18). We performed a periodontal evaluation and collected gingival crevicular fluid to measure MMP-2 and MMP-9 levels. Analysis showed mean and standard deviation of MMP-9 concentrations in the GCF for patients with rosacea was 764.52 ± 569.83 pg/mL; for healthy patients, it was 260.69 ± 170.43 pg/mL (p < 0.05). The diagnosis of rosacea was responsible for the levels of MMP-9 in the GCF (p < 0.05), as opposed to periodontitis, smoking, and age (p > 0.05). The Area under ROC for MMP-9 was 0.869 (95%, C.I: 0.719–0.956), with a sensitivity of 72.22% and specificity of 81.58% for the diagnosis of rosacea. We conclude that the quantification of MMP-9 in the GCF could be used as a biomarker of rosacea. Also, rosacea was responsible for increasing the levels of MMP-9 in the GCF independent of periodontal status.

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Biomarkers in Oral Fluids as Diagnostic Tool for Psoriasis

Cited by 9 publications

References 68 publications

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis

Effect of Treatment With Biologic Agents on the Novel Inflammatory Biomarkers Systemic Immune Inflammation Index and Systemic Inflammation Response Index for Psoriasis

MMP-9 Levels in the Gingival Crevicular Fluid of Chilean Rosacea Patients

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