Biomarkers in Saliva as Diagnostic Tool in Early Diagnosis of Oral Submucous Fibrosis

Mandal, Yagnaseni; Jha, Kunal; Jnaneswar, Avinash

doi:10.4103/jpcdoh.jpcdoh_9_20

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…In our research, we discovered that the least amount of people is aware of the impact of acid–base balance on periodontal pockets. [ 22 ] This is in line with the findings of Axelsson and Lindhe, who investigated the impact of regulated oral hygiene techniques on caries and periodontal disease in adults and concluded that dental caries and periodontal disease are the outcomes of poor oral hygiene.…”

Section: Discussionsupporting

confidence: 86%

Awareness about the significance of acid–base balance of saliva in maintaining oral health

Suresh

Vishnupriya

Jayaraman

et al. 2022

Journal of Advanced Pharmaceutical Technology &Amp; Research

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Saliva is a multilayered secretion. The quality of saliva is just as crucial as the quantity. Saliva is necessary for preserving the integrity of oral structures, personal connections, digestion, and acid–base balance. The acid–base balance in one's oral environment is always being challenged. It happens every time we eat a meal, and when microorganisms are present. At a pH of 5 or 5.5, the demineralization of the enamel and hard tooth structures occurs. This study aimed to raise awareness about the importance of acid–base balance of saliva in dental health. A self-structured questionnaire was prepared to assess the awareness on the importance of acid–base balance in maintaining oral health. The questionnaire consisted of 20 questions, and the results were plotted in a graph. The Chi-square test was employed for evaluating the data, which was done with SPSS software. The study indicated that 91.74% of the participants were aware of the salivary pH in case of healthy gingiva, 34.82% of the respondents were aware of the salivary pH in case of chronic gingivitis, and 20.33% of the respondents were aware of the salivary pH in case of chronic periodontitis. We also correlated our results with gender and year of study. Oral health plays a major role in identifying systemic diseases and hence enough knowledge about various aspects about the oral cavity and its manifestations needs to be created among dental students to ensure that they become efficient dental surgeons in the future. Even though a fair amount of people knew the pH of clinically healthy gingiva, most of them did not know the pH at which periodontitis or gingivitis was caused. Hence, creating awareness about this topic stands vital. Further studies are required for a better understanding of salivary components and how they affect the caries process. The utilization of modified oral molecules as medicinal agents could become a reality with this understanding. Our findings imply that being aware of dietary composition has an impact on acid–base balance. To maintain the correct acid–base balance, more awareness of protein consumption is required.

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Section: Discussionsupporting

confidence: 86%

Awareness about the significance of acid–base balance of saliva in maintaining oral health

Suresh

Vishnupriya

Jayaraman

et al. 2022

Journal of Advanced Pharmaceutical Technology &Amp; Research

View full text Add to dashboard Cite

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“…These biomarkers were detected by methylated polymerase chain reaction (PCR), real-time PCR, western blotting, and staining procedures. 5 6 However, the biopsy sometimes is an invasive procedure with low patient acceptance. Liquid biopsy shows the noninvasive detection of components in biofluids, such as blood serum and saliva.…”

Section: Introductionmentioning

confidence: 99%

Salivary Profile in Oral Submucous Fibrosis: A Scoping Review

Mahdani,

Subarnbhesaj,

Ayuningtyas

et al. 2024

Eur J Dent

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Diagnosing oral submucous fibrosis (OSMF) is invariably challenging. The disease can be detected after reaching its final stage and requires complex treatment. Changes in its salivary profile can be used as a reference to see this disorder and as a basis for diagnostic prediction. This study is aimed to analyze the salivary profile as a diagnosis marker in patients with OSMF. The study using Preferred Reporting Items for Systematic Reviews and Meta-analyses was conducted using PubMed, Science Direct, and Scopus databases. A thorough literature search between 1991 and 2023 was performed. Twenty-eight full-text articles were reviewed in detail. Twenty-eight articles were included; a total of 929 patients of OSMF and 826 controls were found. The scoping review showed that levels of salivary protein (including lactate hydrogenase, immunoglobulin G, immunoglobulin A, S1007A protein, 8-hydroxydeoxyguanosine, 8-isoprostane, malondialdehyde, matrix metalloproteinase-12, salivary C-reactive protein, fibrinogen producing factor, salivary miRNA-21, and salivary lipids [cholesterol, high-density lipoprotein, triglyceride) were higher in OSMF. Meanwhile, trace elements (vitamin C, vitamin E, iron, zinc, and magnesium) were lower; only copper was higher in OSMF patients. Alteration in salivary components such as protein, lipid, and trace elements detection can be a basis for providing a noninvasive supportive examination and thus be used as a diagnosis marker of OSMF.

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Biomarkers in Saliva as Diagnostic Tool in Early Diagnosis of Oral Submucous Fibrosis

Cited by 2 publications

References 15 publications

Awareness about the significance of acid–base balance of saliva in maintaining oral health

Awareness about the significance of acid–base balance of saliva in maintaining oral health

Salivary Profile in Oral Submucous Fibrosis: A Scoping Review

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