Biomarkers in traumatic brain injury: new concepts

Slăvoacă, Dana; Mureșanu, Dafin F.; Bîrle, Codruța; Rosu, Olivia Verisezan; Chirilă, Ioana; Dobra, Iulia; Jemna, Nicoleta; Strilciuc, Ștefan; Vos, Pieter E.

doi:10.1007/s10072-019-04238-y

Cited by 32 publications

(21 citation statements)

References 114 publications

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“…The increasing utilization of objective, physiological evaluation in concussion is encouraging, and not just in EEG/ERPs ( Corbin-Berrigan et al, 2020 ). Consensus is emerging that a variety of additional modalities can be useful, such as blood and fluid biomarkers, genetic profiling, and vestibular and oculomotor assessments ( Kontos et al, 2017 ; McCrea et al, 2017 ; McCrory et al, 2017 ; Wood et al, 2019 ; Slavoaca et al, 2020 ). Recently, machine learning techniques have demonstrated high sensitivity to logistic classification of injury status based on single or multimodal assessments ( Jacquin et al, 2018 ; Boshra et al, 2019 ; Bazarian et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Brain Vital Signs in Elite Ice Hockey: Towards Characterizing Objective and Specific Neurophysiological Reference Values for Concussion Management

et al. 2021

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Background: Prior concussion studies have shown that objective neurophysiological measures are sensitive to detecting concussive and subconcussive impairments in youth ice-hockey. These studies monitored brain vital signs at rink-side using a within-subjects design to demonstrate significant changes from pre-season baseline scans. However, practical clinical implementation must overcome inherent challenges related to any dependence on a baseline. This requires establishing the start of normative reference data sets.Methods: The current study collected specific reference data for N = 58 elite, youth, male ice-hockey players and compared these with a general reference dataset from N = 135 of males and females across the lifespan. The elite hockey players were recruited to a select training camp through CAA Hockey, a management agency for players drafted to leagues such as the National Hockey League (NHL). The statistical analysis included a test-retest comparison to establish reliability, and a multivariate analysis of covariance to evaluate differences in brain vital signs between groups with age as a covariate.Findings: Test-retest assessments for brain vital signs evoked potentials showed moderate-to-good reliability (Cronbach’s Alpha > 0.7, Intraclass correlation coefficient > 0.5) in five out of six measures. The multivariate analysis of covariance showed no overall effect for group (p = 0.105), and a significant effect of age as a covariate was observed (p < 0.001). Adjusting for the effect of age, a significant difference was observed in the measure of N100 latency (p = 0.022) between elite hockey players and the heterogeneous control group.Interpretation: The findings support the concept that normative physiological data can be used in brain vital signs evaluation in athletes, and should additionally be stratified for age, skill level, and experience. These can be combined with general norms and/or individual baseline assessments where appropriate and/or possible. The current results allow for brain vital sign evaluation independent of baseline assessment, therefore enabling objective neurophysiological evaluation of concussion management and cognitive performance optimization in ice-hockey.

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Section: Discussionmentioning

confidence: 99%

Brain Vital Signs in Elite Ice Hockey: Towards Characterizing Objective and Specific Neurophysiological Reference Values for Concussion Management

et al. 2021

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“…S100B is currently used for the same purpose in Europe and may result in a decrease in head CT utilization [24]. Thorough discussions of the current state of TBI biofluid biomarkers can be found in recent reviews by , Gan et al, and Slavoaca et al [25][26][27].…”

Section: Traumatic Brain Injury Biofluid Biomarkersmentioning

confidence: 99%

The Current State of Traumatic Brain Injury Biomarker Measurement Methods

2021

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Traumatic brain injury (TBI) is associated with high rates of morbidity and mortality partially due to the limited tools available for diagnosis and classification. Measuring panels of protein biomarkers released into the bloodstream after injury has been proposed to diagnose TBI, inform treatment decisions, and monitor the progression of the injury. Being able to measure these protein biomarkers at the point-of-care would enable assessment of TBIs from the point-of-injury to the patient’s hospital bedside. In this review, we provide a detailed discussion of devices reported in the academic literature and available on the market that have been designed to measure TBI protein biomarkers in various biofluids and contexts. We also assess the challenges associated with TBI biomarker measurement devices and suggest future research directions to encourage translation of these devices to clinical use.

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“…23 While concentrations of some biomarkers continue to rise within days or even weeks, many biomarkers peak early and decline within a few hours aer the injury, depending on the molecular and cellular origin and the release mechanism. 87,88 Moreover, it must be noted that plasma and serum oen contain different amount of proteins and the concentration of the proteins is strongly affected by the blood pre-treatment procedure (anti-clotting factors, clotting reagents). [89][90][91] Some studies indicate that serum samples are not recommended for quantifying certain biomarkers (e.g.…”

Section: Introductionmentioning

confidence: 99%