Biomarkers of Acute Kidney Injury

Vaidya, Vishal S.; Ferguson, Michael; Bonventre, Joseph V.

doi:10.1146/annurev.pharmtox.48.113006.094615

Cited by 643 publications

(505 citation statements)

References 135 publications

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“…We believe our description of Roundup-induced apoptosis is novel.. KIM-1 is a type I cell membrane glycoprotein expressed by tubule epithelial cells in response to injury. It appears in urine after proximal tubular injury (Ferguson et al, 2008;Hoffmann et al, 2010;Vaidya et al, 2008a). In this study, uKIM-1 outperformed other plasma and urinary biomarkers in early detection of AKI.…”

Section: Discussionmentioning

confidence: 68%

“…Cys-C is a 13-kDa protein that is freely filtered via the glomerulus but reabsorbed and degraded in lysosomes of proximal tubule cells. It is not secreted by kidney tubules (Ferguson et al, 2008;Vaidya et al, 2008a). Recently, serum or pCys-C levels were found to perform better than pCr in some patients as a surrogate measure of kidney function (GFR) .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several studies have suggested that pCr is not sensitive enough to detect early kidney injury or predict subsequent functional change (Sherwin et al, 2012;Toto, 1995;Vaidya et al, 2008b;Woitas et al, 2000). Other biomarkers including interleukin-18 (IL-18), cystatin-C (Cys-C), kidney injury molecule-1 (KIM-1), 2-microglobulin (2-M), albumin (Alb), neutrophil gelatinaseassociated lipocalin (NGAL) and osteopontin (Opn) have been proposed for the early and sensitive detection of AKI and functional loss Ferguson et al, 2008;Nguyen and Devarajan, 2008;Noiri et al, 2009;Vaidya et al, 2008a;Vaidya et al, 2008b), and may have greater sensitivity than pCr.…”

Section: Introductionmentioning

confidence: 99%

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Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance

Wunnapuk¹,

Liu²,

Gobé³

et al. 2014

Toxicology Letters

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Accidental or intentional ingestion of glyphosate surfactant-based herbicides, like Roundup, leads to nephrotoxicity as well as death. In this study, a panel of kidney injury biomarkers was evaluated in terms of suitability to detect acute kidney injury and dysfunction. The Roundup intoxication model involved oral administration of glyphosate to rats at dose levels of 250, 500, 1200 and 2500 mg/kg. Urinary and plasma biomarker patterns were investigated at 8, 24 and 48 hours after dosing.Biomarkers were quantified by absolute concentration; by normalising to urine creatinine; and by calculating the excretion rate. The diagnostic performances of each method in predicting of acute kidney injury were compared. By Receiver Operating Characteristic (ROC) analysis of the selected biomarkers, only urinary kidney injury molecule-1 (KIM-1) best predicted histological changes at 8 h (best cut-off point > 0.00029 µg/ml). Plasma creatinine performed better than other biomarkers at 24 h (best cut-off point > 0.21 mg/dl). Urinary KIM-1 was the best early biomarker of kidney injury in this glyphosate-induced nephrotoxicity model.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance

Wunnapuk¹,

Liu²,

Gobé³

et al. 2014

Toxicology Letters

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“…Several promising biomarkers have emerged from these studies (16,17). Analysis of temporal and spatial differences in their expression highlights the cellular complexity of the AKI response (ref.…”

Section: Introductionmentioning

confidence: 99%

Cell-specific translational profiling in acute kidney injury

et al. 2014

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Acute kidney injury (AKI) promotes an abrupt loss of kidney function that results in substantial morbidity and mortality. Considerable effort has gone toward identification of diagnostic biomarkers and analysis of AKI-associated molecular events; however, most studies have adopted organ-wide approaches and have not elucidated the interplay among different cell types involved in AKI pathophysiology. To better characterize AKI-associated molecular and cellular events, we developed a mouse line that enables the identification of translational profiles in specific cell types. This strategy relies on CRE recombinase-dependent activation of an EGFP-tagged L10a ribosomal protein subunit, which allows translating ribosome affinity purification (TRAP) of mRNA populations in CRE-expressing cells. Combining this mouse line with cell type-specific CRE-driver lines, we identified distinct cellular responses in an ischemia reperfusion injury (IRI) model of AKI. Twenty-four hours following IRI, distinct translational signatures were identified in the nephron, kidney interstitial cell populations, vascular endothelium, and macrophages/monocytes. Furthermore, TRAP captured known IRI-associated markers, validating this approach. Biological function annotation, canonical pathway analysis, and in situ analysis of identified response genes provided insight into cell-specific injury signatures. Our study provides a deep, cell-based view of early injury-associated molecular events in AKI and documents a versatile, genetic tool to monitor cell-specific and temporal-specific biological processes in disease modeling.

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“…In patients with preexisting renal impairment, a nephrologist should assess the risk of postprocedural dialysis. In all patients, we advocate careful technique, minimal contrast load, and adequate postprocedural hydration [9,18]. Despite these precautions, catastrophic renal failure risk may remain, as the precise pathophysiology of contrastinduced nephropathy has yet to be identified [10,15,17].…”

Section: Discussionmentioning

confidence: 99%

Embolization of Hypervascular Bone Metastases Reduces Intraoperative Blood Loss: A Case-control Study

Pazionis

Papanastassiou

Maybody

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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Background Small case series suggest that preoperative transcatheter arterial embolization minimizes bleeding and facilitates surgery for hypervascular metastatic bone tumors. However, control groups would make our confidence in clinical recommendations stronger, but small patient numbers make prospective trials difficult to conduct on this topic. Questions/purposes In this case-control study, we asked whether (1) patients who undergo embolization have less estimated blood loss and/or shorter operative time than patients who do not have embolization; (2) larger tumor size, greater initial tumor vascularity, and longer interval from embolization to surgery are associated with greater estimated blood loss and packed red blood cell transfusion volume; and (3) embolization does not affect renal function in patients with normal preoperative renal function. Methods We retrospectively reviewed records of patients with hypervascular bone metastases treated at our institution between 1998 and 2008. Twenty-seven patients with renal cell carcinoma and 12 with thyroid carcinoma who underwent embolization before 41 surgical procedures were matched to 41 patients who did not have embolization with respect to age, diagnosis, tumor size and potential vascularity, and procedure type; matching was performed without knowledge of outcomes. In univariate and multivariate analyses, age, tumor size, use of embolization, surgery type and risk, embolization-to-surgery interval, and degree of devascularization were evaluated for correlations with estimated blood loss, packed red blood cell transfusion volume, operative time, and postembolization renal function. Results Overall, patients who had embolization had less mean estimated blood loss (0.90 versus 1.77 L; p = 0.002), packed red blood cell transfusion volume (2.15 versus 3.56 U; p = 0.020), and operative time

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Biomarkers of Acute Kidney Injury

Cited by 643 publications

References 135 publications

Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance

Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance

Cell-specific translational profiling in acute kidney injury

Embolization of Hypervascular Bone Metastases Reduces Intraoperative Blood Loss: A Case-control Study

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