Biomarkers of adverse childhood experiences: A scoping review

Deighton, Stephanie; Neville, Alexandra; Pusch, Dennis; Dobson, Keith S.

doi:10.1016/j.psychres.2018.08.097

Cited by 127 publications

(104 citation statements)

References 65 publications

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“…We know most about the developmental impact of toxic stressors. While there are myriad individual patterns of exposures, traumatic stress or material deprivation have larger effects early in life than when they occur at later periods; Early life adversity is predictive of a range of poor outcomes, including poor mental health, health behaviors, biomarkers of aging, and earlier disease onset ( Deighton et al, 2018 ; Hughes et al, 2017 ) although plasticity is still possible ( McEwen and Morrison, 2013 ). Given the sensitive period of pregnancy, it is not surprising there is evidence of transgenerational effects of stress and pregnancy complications on systems regulating aging like telomeres and epigenetics ( Epel, 2020 ; Girchenko et al, 2017 ; Ross et al, 2020 ).…”

Section: An Integrative Model Of Stress and Aging Stress Acceleratiomentioning

confidence: 99%

The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging

Epel¹

2020

Ageing Research Reviews

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Highlights Social, behavioral and psychological drivers of aging are an important part of geroscience. Toxic stress accelerates biological aging processes whereas hormetic stress can slow aging. However, the types, timing, and frequency of hormetic stress, especially in humans, needs to be better delineated in order to be useful. Stress resilience, a larger umbrella term including hormetic stress that focuses on recovery, can be measured across levels--cellular, physiological psychological and social functioning. Developing a deeper understanding of stress resilience will lead to more targeted innovative interventions.

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Section: An Integrative Model Of Stress and Aging Stress Acceleratiomentioning

confidence: 99%

The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging

Epel¹

2020

Ageing Research Reviews

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“…A recent review 40 Regarding endocrine systems, early parental death has been related to changes in the HPA (hypothalamic-pituitary-adrenal) axis, with increased cortisol. 30 A review on dementia 27 found that there is sufficient proven evidence to consider adverse childhood experiences as a risk factor for this condition.…”

Section: Biomarkers Of Adverse Childhood Experiencesmentioning

confidence: 99%

Early parental death and psychosocial risk factors for dementia: A case–control study in Europe

Conde-Sala

Garré-Olmo

2020

Int J Geriat Psychiatry

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Objectives To assess the association between early parental death and the risk of dementia in adult life and to examine the risk factors associated with early parental death in people with and without dementia. Methods/design A population‐based case–control study of a sample of 65 997 participants from the Survey of Health, Ageing and Retirement in Europe study. Early parental death was operationalized as parental death at the age of ≤16 years. Main analyses were conducted using bivariate and multivariate logistic regression analyses. Results The odds ratio (OR) for dementia in individuals who experienced early parental death (father or mother) at the age of ≤16 years was 1.83 (95%CI 1.61‐2.09) and 1.54 (95%CI 1.35‐1.76) adjusted for age, gender and education. In the multivariate logistic regression analysis carried out with the whole sample, early parental death increased the risk of dementia (OR = 1.50, 95%CI 1.31‐1.72), along with older age (OR = 5.92, 95%CI 4.86‐7.17), neuroticism (OR = 2.94, 95%CI 2.61‐3.31), low education level (OR = 1.84, 95%CI 1.64‐2.05) and low income (OR = 1.49, 95%CI 1.34‐1.67). Discussion Early parental death (≤16 years) was associated with an increased risk of dementia. We discuss the neurobiological markers associated with adverse childhood experiences (ACEs) and dementia as well as interventions to counteract the negative health effects on adults. J Am Geriatr Soc 68:‐, 2020.

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“…Studies have repeatedly detected increased levels of IL-6, TNF-α and CRP associated with exposure to adversity in childhood. 42 Elevated levels of CRP have also been described in depressed children and adults exposed to maltreatment during childhood, but not in depressed individuals with no history of childhood adversity. 43,44 Therefore, inflammation could potentially mediate the effects of childhood abuse on mental health, with higher levels of immune system responses being linked to depression, and potentially increasing subsequent risk for CVD.…”

Section: Stress and Hpa Axismentioning

confidence: 99%

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

Mattina

Lieshout

Steiner

2019

Therapeutic Advances in Cardiovascular Disease

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Women are at increased risk for developing depression and cardiovascular disease (CVD) across the lifespan and their comorbidity is associated with adverse outcomes that contribute significantly to rates of morbidity and mortality in women worldwide. Immunesystem activity has been implicated in the etiology of both depression and CVD, but it is unclear how inflammation contributes to sex differences in this comorbidity. This narrative review provides an updated synthesis of research examining the association of inflammation with depression and CVD, and their comorbidity in women. Recent research provides evidence of pro-inflammatory states and sex differences associated with alterations in the hypothalamic-pituitary-adrenal axis, the renin-angiotensin-aldosterone system and the serotonin/kynurenine pathway, that likely contribute to the development of depression and CVD. Changes to inflammatory cytokines in relation to reproductive periods of hormonal fluctuation (i.e. the menstrual cycle, perinatal period and menopause) are highlighted and provide a greater understanding of the unique vulnerability women experience in developing both depressed mood and adverse cardiovascular events. Inflammatory biomarkers hold substantial promise when combined with a patient's reproductive and mental health history to aid in the prediction, identification and treatment of the women most at risk for CVD and depression. However, more research is needed to improve our understanding of the mechanisms underlying inflammation in relation to their comorbidity, and how these findings can be translated to improve women's health.

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Biomarkers of adverse childhood experiences: A scoping review

Cited by 127 publications

References 65 publications

The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging

The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging

Early parental death and psychosocial risk factors for dementia: A case–control study in Europe

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

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