Biomarkers of Atrial Fibrillation: Which One Is a True Marker?

Ardhianto, Pipin; Yuniadi, Yoga

doi:10.1155/2019/8302326

Cited by 12 publications

(10 citation statements)

References 58 publications

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“…[20][21][22][23][24] However, whether these biomarkers could stage AF and predict AF recurrence after PVI treatment is unknown. 25 Our previous study identified a key role of oxidative DNA damage in driving experimental and clinical AF. 12 Based on these mechanistic findings, we investigated oxidative DNA damage levels in serum samples of AF patients.…”

Section: Serum 8-ohdg Level As Potential Biomarker For Afmentioning

confidence: 98%

Blood-based 8-hydroxy-2′-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation

Zhang

Ramos

et al. 2021

Heart Rhythm

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BACKGROUND Recent research findings have revealed a key role of oxidative DNA damage in the pathogenesis of atrial fibrillation (AF). Therefore, the circulating oxidative DNA damage marker 8-hydroxy-2 0 -deoxyguanosine (8-OHdG) may represent a biomarker for staging AF and identifying patients at risk for AF recurrence and postoperative atrial fibrillation (POAF) after treatment.OBJECTIVE The purpose of this study was to investigate whether serum levels of 8-OHdG correlate with the stage of AF, recurrence after AF treatment, and onset of POAF after cardiac surgery.METHODS In this prospective observational study, 8-OHdG levels were detected by enzyme-linked immunosorbent assay in human serum samples. Blood samples were collected from control patients without AF history; patients with paroxysmal AF and persistent AF undergoing electrical cardioversion or pulmonary vein isolation (PVI); and patients with sinus rhythm (SR) undergoing cardiac surgery. AF recurrence was determined during 12-month follow-up. Univariate and multivariate analyses were used to identify changes in 8-OHdG levels between the groups.RESULTS Compared to the control group, 8-OHdG levels in the patient groups gradually and significantly increased during arrhythmia progression. 8-OHdG levels in AF patients showing AF recurrence after PVI treatment were significantly increased compared to patients without AF recurrence. Moreover, in SR patients undergoing cardiac surgery, 8-OHdG levels were significantly elevated in those showing POAF compared to patients without POAF.CONCLUSION 8-OHdG level may represent a potential diagnostic biomarker for AF staging as well as for predicting AF recurrence and POAF after treatment.

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Section: Serum 8-ohdg Level As Potential Biomarker For Afmentioning

confidence: 98%

Blood-based 8-hydroxy-2′-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation

Zhang

Ramos

et al. 2021

Heart Rhythm

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“…Various data have shown superior results of the troponin and brain natriuretic peptide levels compared to the risk scores recommended in the current guidelines. However, more studies are needed to confirm the position of biomarkers in determining the risk of stroke and bleeding in patients diagnosed with atrial fibrillation [9].…”

Section: Biomarkers 21 Natriuretic Peptidesmentioning

confidence: 99%

Biomarkers Utility: At the Borderline between Cardiology and Neurology

Ion

Stafie

Mitu

et al. 2021

JCDD

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Biomarkers are important diagnostic and prognostic tools as they provide results in a short time while still being an inexpensive, reproducible and accessible method. Their well-known benefits have placed them at the forefront of research in recent years, with new and innovative discoveries being implemented. Cardiovascular and neurological diseases often share common risk factors and pathological pathways which may play an important role in the use and interpretation of biomarkers’ values. Among the biomarkers used extensively in clinical practice in cardiology, hs-TroponinT, CK-MB and NTproBNP have been shown to be strongly influenced by multiple neurological conditions. Newer ones such as galectin-3, lysophosphatidylcholine, copeptin, sST2, S100B, myeloperoxidase and GDF-15 have been extensively studied in recent years as alternatives with an increased sensitivity for cardiovascular diseases, but also with significant results in the field of neurology. Thus, given their low specificity, the values interpretation must be correlated with the clinical judgment and other available investigations.

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“…Therefore, serum diagnostic biomarkers of AF will be highly valuable. Biomarkers have been widely utilized in the management of cardiovascular disorders, such as acute myocardial infarction and heart failure, and have contributed to risk predictors and prognostic values [7]. On the contrary, the application of biomarkers in AF management has not yet well established in the major guidelines until the 2016 European Society of Cardiology guideline for management of atrial brillation developed in collaboration with EACTS [8].…”

Section: Introductionmentioning

confidence: 99%

Integrated Analysis Identifies Key lncRNA-mRNA Network in Atrial Fibrillation

Song

Liu

et al. 2021

Preprint

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Background: Atrial fibrillation (AF), the most common cardiac arrhythmias, is associated with the risk of stroke and pronounced morbidity and mortality. The application of biomarkers in the management of AF has been grown as an interesting topic. Long non-coding RNAs (lncRNAs) have been reported to participate in the pathogenesis of cardiovascular diseases by regulating mRNA networks. Results: In this study, we firstly used two AF cohorts to identify circulating lncRNAs and mRNAs with potential diagnostic prediction value. The expression of 8,164 lncRNAs and 14,508 mRNAs were quantified in these two cohorts with lncRNA microarray. By using a stringent threshold (P < 0.01, fold change > 2.0 or < 0.5), we identified 10 lncRNAs and 7 mRNAs were significantly differentially expressed in AF in both cohorts. To further explore the function of these significantly dysregulated lncRNA and mRNA, we performed co-expression analysis by using RNA-seq data of 429 atrial appendage tissue samples. Interestingly, we found a significant lncRNA-mRNA network for 5 lncRNAs (AC109460.1, AL031123.1, MIAT, PTPRG-AS1 and ZNF815P) and 4 mRNAs (D2HGDH, SPNS1, KCND2 and TNFAIP8L3) with Pearson correlation r > 0.3 (all P < 10-8). Moreover, in silico analysis showed that the lncRNA MIAT and PTPRG-AS1 may serve as miRNA sponges to regulate D2HGDH, SPNS1, KCND2 and TNFAIP8L3.Conclusions: Our study suggested that the circulating lncRNA-mRNA network of MIAT and PTPRG-AS1 play an important role in AF and may be considerable diagnostic biomarkers. These results may contribute to the precise diagnosis and early detection of this disease.

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Biomarkers of Atrial Fibrillation: Which One Is a True Marker?

Cited by 12 publications

References 58 publications

Blood-based 8-hydroxy-2′-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation

Blood-based 8-hydroxy-2′-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation

Biomarkers Utility: At the Borderline between Cardiology and Neurology

Integrated Analysis Identifies Key lncRNA-mRNA Network in Atrial Fibrillation

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