Biomarkers of Cholestasis

Pieters, Alanah; Gijbels, Eva; Cogliati, Bruno; Annaert, Pieter; Devisscher, Lindsey; Vinken, Mathieu

doi:10.2217/bmm-2020-0691

Cited by 17 publications

(6 citation statements)

References 144 publications

(210 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, a significant absolute increase in total glycine-conjugated BA was evident in female NAFLD. The secondary BA were not significantly different to controls, but higher total primary BA may indicate a gender-dependent disposition to cholestasis [ 22 ]. Accordingly [ 23 ], the female controls had lower median levels of total primary BA compared to male controls.…”

Section: Discussionmentioning

confidence: 99%

Gender-Specific Bile Acid Profiles in Non-Alcoholic Fatty Liver Disease

Fitzinger,

Rodriguez-Blanco,

Herrmann

et al. 2024

Nutrients

View full text Add to dashboard Cite

Background: Non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. A main cause is the obesogenic, so-called Western lifestyle. NAFLD follows a long, unperceived course, and ends potentially fatally. Early diagnosis of aggressive subtypes saves lives. So far, non-invasive means of detection are limited. A better understanding of the pathogenic interplay among insulin resistance, immune inflammation, microbiome, and genetic background is important. Metabolomics may give insight into these interlaced processes. Methods: In this study, we measured bile acids (BA) in the plasma of adult NAFLD and alcohol-associated liver disease (ALD) patients and healthy controls with targeted mass spectrometry. We focused on gender-related bile acid production pathology in NAFLD and ALD. Results: Compared to healthy controls, women with NAFLD had significantly higher concentrations of total BA, total primary BA, total cholic (CA), total chenodeoxycholic (CDCA), total glycine-conjugated, and total non-12-a-OH BA. Concerning subtypes, glycocholic (GCA) and glycochenodeoxycholic (GCDCA), BA were elevated in women with NAFLD. In contrast, men with NAFLD had no significantly altered total BA fractions. However, the subtypes GCA, glycodeoxycholic (GDCA), glycolithocholic (GLCA), lithocholic (LCA), taurolithocholic (TLCA), and tauroursodeoxycholic acid (TUDCA) were elevated, while CA was significantly decreased. In NAFLD, except ursodeoxycholic acid (UDC), all total BA correlated significantly positively in both sexes with the ELF score, while in ALD, only males showed significant correlations exceptive for total UDC BA. In NAFLD, total BA, total primary BA, total secondary BA, total free secondary BA, total CA, total CDCA, total taurine conjugated, total glycine conjugated, total 12-a-OH, and total non-12-a-OH were significantly higher in cases of a high enhanced liver fibrosis (ELF) score above 9.8. In ALD, total UDC was additionally elevated. Between NAFLD with and without NASH, we found no significant differences. Conclusion: Our data show gender-specific bile acid profiles in NAFLD and markedly different BA patterns in ALD. Women with NAFLD had more severe cholestasis. Men may better compensate fat storage-driven bile acid dynamics, indicated by higher levels of taurine-conjugated BA, which associate with beneficial metabolic functions.

show abstract

Section: Discussionmentioning

confidence: 99%

Gender-Specific Bile Acid Profiles in Non-Alcoholic Fatty Liver Disease

Fitzinger,

Rodriguez-Blanco,

Herrmann

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Table 2 summarizes specific hereditary cholestatic liver diseases and the genes with causative mutations. 15 However, mutations in individual genes account for only a small portion of liver diseases, and most hereditary liver diseases are caused by mutations of multiple genes or a combination of gene mutations and environmental factors.…”

Section: Molecular Markersmentioning

confidence: 99%

Guidelines for the Management of Cholestatic Liver Diseases (2021)

Lu¹

2022

J Clin Transl Hepatol

View full text Add to dashboard Cite

In 2015, the Chinese Society of Hepatology and the Chinese Society of Gastroenterology issued a consensus statement on the diagnosis and management of cholestatic liver diseases. More clinical data on this topic have appeared during recent years. The Autoimmune Liver Disease Group of the Chinese Society of Hepatology organized an expert group to review recent evidence and provide an update to these previous guidelines. Herein, we provide 22 recommendations as a working reference for the management of cholestatic liver diseases by clinical practitioners.

show abstract

“…Serum γ-glutamyltransferase (GGT) is a trypsin widely distributed on the surface of glandular and ductal epithelial cells, mainly secreted by the liver, and it is also the most sensitive liver enzyme to reflect biliary obstruction and liver injury [9]. Studies have shown that GGT has a certain correlation with the prognosis and survival of various digestive tract malignancies, but due to a variety of other diseases and conditions (such as renal insufficiency, diabetes, pancreatitis, myocardial infarction, obesity and alcohol intake) Serum GGT levels are elevated and therefore lack specificity [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Preoperative CA19-9 and GGT ratio as a prognostic indicator in ampullary carcinoma

et al. 2023

View full text Add to dashboard Cite

Background and aims In recent years, more and more inflammatory indicators have been studied to predict the long-term survival of patients with ampullary carcinoma (AC) after radical resection, but these prognostic indicators are still controversial. Therefore, based on previous inflammation scores, this study established a novel, easily accessible, more feasible and more predictive prognostic marker [Carbohydrate antigen199 to gamma-glutamyltransferase ratio (CA19-9/GGT)] to better assess the prognostic significance in AC patients undergoing radical resection. Methods Overall survival (OS) and recurrence-free survival (RFS) were analyzed by Cox regression model. Correlation between CA19-9/GGT and clinicopathological variables were analyzed by Chi-squared test, Fisher ' s exact test, independent sample t test and Mann–Whitney U test. The performance of prognostic indexes is compared by the consistency index (C-index). The prediction accuracy of nomogram is further confirmed by calibration curve and decision curve analysis (DCA). Results CA19-9/GGT was an independent risk factor affecting OS [P = 0.001, hazard ratio (HR) 2.459, 95% confidence intervals (CI) 1.450–4.167] and RFS (P = 0.002, HR 2.333, 95% CI 1.371–3.971) in multivariate analysis. The optimal cut-off value of CA19-9/GGT was 0.14. In CA19-9/GGT correlation analysis, high risk group (> 0.14) was significantly associated with poor prognosis. The predictive performance of CA19-9/GGT (OS: C-index = 0.753, RFS: C-index = 0.745) was confirmed to be superior to other prognostic indicators according to the C-index. Compared with the simple AJCC staging system, the Nomogram prediction model (OS: C-index = 0.787, RFS: C-index = 0.795) established by the combination of CA19-9/GGT and AJCC 8th TNM staging system has higher prediction accuracy. Conclusions CA19-9/GGT was an independent prognostic indicator after radical resection of AC. Incorporating CA19-9/GGT into the AJCC TNM staging system optimized the prediction accuracy of the TNM staging system, and further verified the predictive value of CA19-9/GGT.

show abstract

Biomarkers of Cholestasis

Cited by 17 publications

References 144 publications

Gender-Specific Bile Acid Profiles in Non-Alcoholic Fatty Liver Disease

Gender-Specific Bile Acid Profiles in Non-Alcoholic Fatty Liver Disease

Guidelines for the Management of Cholestatic Liver Diseases (2021)

Preoperative CA19-9 and GGT ratio as a prognostic indicator in ampullary carcinoma

Contact Info

Product

Resources

About