Biomarkers of Dietary Intake Are Correlated with Corresponding Measures from Repeated Dietary Recalls and Food-Frequency Questionnaires in the Adventist Health Study-2

Abstract

Many biomarkers that have relatively high-valued correlations with dietary intake were identified and were usually of similar value in black and non-black subjects. These may be used to correct effects of dietary measurement errors in the AHS-2 cohort, and in some cases they also provide evidence supporting the validity of the dietary data.

Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly

“…Regarding the food matrix, we observed a stronger association for the estimate based on studies that included diet alone in comparison to those in which folate supply was from diet and supplements. This finding is in line with results from a similar systematic review of RCTs among women in childbearing age and in pregnancy and lactation [29]. Because synthetic folate is 1.7 times more bioavailable than naturally occurring folate [14, 37], total dietary folate should be expressed as DFE to account for this difference in bioavailability.…”

“…Also, some studies used 100–200 μg/day of folic acid as a conservative estimate of intake from supplements based on supplements available on the market, and added that amount without conversion to DFE to total dietary folate [18, 19, 25]. Finally, the proportion of regular and occasional supplement users varied between 4.8 and 26%, with average supplement dose up to 200 μg/day [11, 12, 17, 18, 22, 25, 27, 29]. This fact along with the lack of standardization in reporting total folate intake as DFE will have affected the estimates and contributed to heterogeneity of stratum-specific estimates.…”

“…Each study provided at least one independent estimate; for some studies, 2 or 3 estimates were obtained because of stratification by gender [20, 25], by genotype [15, 17], by race [29, 32], or by diet type [23]. Where data on folate intake and status were available for males and females separately, but there was only one estimate of the association [13, 16, 25, 27]; the pooled estimates of mean folate intake and status were calculated and used in the analysis.…”

“…A consensus on the judgments was reached following discussion of each study. Thirteen studies [12, 15, 17, 19-25, 27, 30, 31] were judged at adequate risk of bias, 6 studies [14, 16, 18, 26, 29, 32, 34] were judged at a moderate risk of bias, and 4 studies was judged at a high risk of bias [11, 13, 28, 33]. …”

Validação de um questionário semiquantitativo de frequência alimentar e de seu Índice de Qualidade da Dieta Revisado para crianças e adolescentes de 9 a 13 anos utilizando biomarcadores dietéticos - Ribeirão Preto, SP

“…Concentrações plasmáticas de retinol, β-caroteno e α-tocoferol são sensíveis à ingestão alimentar atual 145,146 e têm sido sugeridos como biomarcadores da exposição a nutrientes antioxidantes [147][148][149] , apresentando boa correlação com o consumo de frutas e vegetais [150][151][152][153][154] .…”