Biomarkers of disease activity in patients with chronic
spontaneous urticaria

Plavšić, Aleksandra; Spirić, Vesna Tomić; Arandjelovic, Snezana; Mišković, Rada; Dimitrijevič, Milan R.; Perić-Popadić, Aleksandra

doi:10.5114/ada.2021.112276

Cited by 12 publications

(9 citation statements)

References 27 publications

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“…Kasperska-Zajac et al also recorded significantly higher serum CRP values than in healthy subjects [median 9.2 vs. 0.74 mg/L]; the median for serum CRP was lower in our study (1.25 mg/L) [ 21 ]. In our trial, CRP was not related to CSU severity at all, similar to results obtained by Plavsic et al, who did not find a significant correlation between CRP and CSU activity [ 27 ]. The limitations of both studies could be the small number of patients enrolled.…”

Section: Discussionsupporting

confidence: 91%

Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study

Kuna,

Štefanović,

Ladika Davidović

et al. 2023

Biomedicines

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(1) Background: To assess the relationship between serum interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values and disease severity in patients with chronic spontaneous urticaria (CSU) and to examine which of these serum biomarkers better indicates disease severity. (2) Methods: Our pilot study included 20 patients with CSU who filled out questionnaires concerning disease severity and quality of life (the Urticaria Activity Score summed over 7 days [UAS7], the once-daily Urticaria Activity Score [UAS], the Urticaria Control Test [UCT], and the Dermatology Life Quality Index [DLQI]). Blood samples were taken to measure IL-6, ESR and CRP. (3) Results: ESR significantly correlated with the UAS7 (linear and moderate correlation; r = 0.496; p = 0.026), while CRP did not correlate with disease severity. IL-6 correlated with the once-daily UAS (r = 0.472; p = 0.036) and DLQI (r = 0.504; p = 0.023) (linear and moderate correlation) but not the UAS7 or UCT. (4) Conclusions: IL-6 was a better indicator of the once-daily UAS and DLQI, while ESR was a better indicator of the UAS7 (there was no correlation between IL-6, CRP and ESR parameters). Although our results are promising, this study should be conducted with a larger number of CSU patients.

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Section: Discussionsupporting

confidence: 91%

Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study

Kuna,

Štefanović,

Ladika Davidović

et al. 2023

Biomedicines

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“…Most studies on CRP levels in CSU found them to be linked with disease activity, 8,27,32–34 but two did not 26,29 . In our study, total IgE and CRP levels were highest in severe disease and lowest in mild disease activity.…”

Section: Discussioncontrasting

confidence: 66%

“…Most studies on CRP levels in CSU found them to be linked with disease activity, 8 , 27 , 32 , 33 , 34 but two did not. 26 , 29 In our study, total IgE and CRP levels were highest in severe disease and lowest in mild disease activity. However, they were not correlated with each other, which supports their association with different CSU endotypes, that is, autoallergic and autoimmune CSU.…”

Section: Discussionsupporting

confidence: 50%

“…It is well known that CRP and total IgE levels are elevated on average in CSU, and it has also been suggested that they are potential biomarkers for disease activity. 7 , 8 , 26 , 27 Although the rates reported in studies vary, IgE is elevated in approximately half of the CSU patients 7 , 28 and CRP in about one‐third of CSU patients. 8 In our study, IgE elevation was found in 51.4% of the patients and CRP in 36.2%, confirming previous reports.…”

Section: Discussionmentioning

confidence: 99%

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In chronic spontaneous urticaria, IgE and C‐reactive protein are linked to distinct microRNAs and interleukin‐31

Karstarli Bakay,

Demir,

Cicek

et al. 2023

Clinical & Translational All

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BackgroundChronic spontaneous urticaria (CSU) is a common and disabling disease. Assessments of IgE and C‐reactive protein (CRP) are recommended in the diagnostic work‐up, but the role and clinical relevance of these biomarkers are not well characterized. Moreover, it remains unknown if elevated levels of IgE or CRP are linked to CSU microRNA (miRNA) signatures or interleukin 31 (IL‐31).MethodsWe measured IgE and CRP serum levels in 47 CSU patients (and 45 healthy controls) and determined CSU disease activity using the urticaria activity score (UAS7). Expression levels of miR‐155 and miR‐221 were assessed by RT‐PCR, and IL‐31 levels were determined by ELISA.ResultsTotal IgE and CRP levels were independently increased in CSU patients. IgE and CRP levels were highest and lowest in patients with high and mild disease activity. IgE levels correlated with miR‐155 levels, whereas CRP levels correlated with miR‐221 levels. miR‐155 and miR‐221 were significantly overexpressed in CSU patients. ROC analyses linked miRNA‐155 and CSU with a sensitivity of 79% and specificity of 87%, and miRNA‐221 and CSU with a sensitivity of 75% and specificity of 91%. High CRP and miR‐221 expression levels were linked to elevated levels of IgG anti‐TPO and IL‐31.ConclusionIgE and CRP are useful biomarkers for disease activity in CSU, with distinct miRNA profiles. High CRP and miR‐221 levels may point to autoimmune CSU and a role for IL‐31.

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“…Of them CSU type IIb which have the higher activity score, autoimmune diseases associated, longer persistence and lower responsiveness to 2 nd generation antihistamines (8,9) . Many biomarkers were explored for severity evaluation such as d dimer, C reactive Protein and ESR (10).…”

Section: Introductionmentioning

confidence: 99%

Could Peripheral Eosinopenia be Used as a Prognostic Biomarker for Chronic Spontaneous Urticaria?

ELAMAWY

Nazmy²,

Mohamed³

2023

The Egyptian Journal of Hospital Medicine

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Background: Chronic spontaneous urticaria (CSU) is a chronic, sometimes debilitating skin disorder characterized by the appearance of wheals, angioedema, or both for a period of more than 6 weeks. Many biomarkers were explored for severity evaluation such as d dimer and C Reactive Protein. Objectives: The aim of the current study is to assess the usefulness of peripheral eosinopenia as a valuable and an applicable biomarker for CSU severity. Patients and methods: A case control study was conducted on 60 CSU patients. Patients were divided into 30 patients with mild UAS7 score <15 representing the controls and 30 patients with severe UAS7 score >28 representing the cases. Eosinophils count and other variables were compared. Results: Severe cases demonstrated significantly higher age (median 34 vs. 29 years, P =0.043), CRP (14 vs. 2 mg/L, P <0.001) and positive ASST (56.7% vs. 23.3%, P =0.008). In contrast, severe cases demonstrated significantly lower eosinophilic count (median 21 vs. 123 cell/mm 3 , P <0.001), basophilic count (median 5 vs. 25 cell/mm 3 , P <0.001), and total IgE (median 93 vs. 221.5 IU/ml, P <0.001). The eosinophilic count showed a significant-excellent AUC of 0.954. The best cutoff point was ≤70, at which sensitivity and specificity were 96.7% and 86.7%, respectively. Conclusion: Peripheral eosinophils are significantly lower count in severe urticarial patients (P value <0.001) and this could be used as a simple and accessible tool for monitoring urticaria activity.

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Biomarkers of disease activity in patients with chronic spontaneous urticaria

Cited by 12 publications

References 27 publications

Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study

Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study

In chronic spontaneous urticaria, IgE and C‐reactive protein are linked to distinct microRNAs and interleukin‐31

Could Peripheral Eosinopenia be Used as a Prognostic Biomarker for Chronic Spontaneous Urticaria?

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