2011
DOI: 10.3109/1354750x.2011.587893
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Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?

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Cited by 174 publications
(138 citation statements)
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References 142 publications
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“…The release of sICAM-1 is modulated by several cytokines including TNF-α, IL-1β, and IL-6, with sICAM-1 playing an important role in both innate and adaptive immune responses (29). It is involved in the transendothelial migration of leukocytes to the sites of inflammation, as well as interactions between antigen-presenting cells and T cells, and has been proposed as a reliable marker of general endothelial activation in response to an inflammatory stimulus (30). Although elevated sICAM-1 has been observed in preterm infants with chronic lung disease (31) and blood culturepositive sepsis (32), the posttransfusion levels observed in the current study were significantly lower.…”
Section: Discussioncontrasting
confidence: 56%
“…The release of sICAM-1 is modulated by several cytokines including TNF-α, IL-1β, and IL-6, with sICAM-1 playing an important role in both innate and adaptive immune responses (29). It is involved in the transendothelial migration of leukocytes to the sites of inflammation, as well as interactions between antigen-presenting cells and T cells, and has been proposed as a reliable marker of general endothelial activation in response to an inflammatory stimulus (30). Although elevated sICAM-1 has been observed in preterm infants with chronic lung disease (31) and blood culturepositive sepsis (32), the posttransfusion levels observed in the current study were significantly lower.…”
Section: Discussioncontrasting
confidence: 56%
“…Edn1 encodes a proprotein that is processed sequentially to generate the secreted peptide ET-1. ET-1 has both vasoconstrictive and proinflammatory functions and has been linked to numerous inflammatory diseases (32)(33)(34). Therefore, we used the Edn1 proximal promoter in reporter assays to investigate mechanisms by which Hdac7 promotes TLR4 responses.…”
Section: Identification Of Hdac7 As a Candidate Promoter Of Tlr4mentioning
confidence: 99%
“…Upon activation, endothelial cells and adhesion molecules are shed. The increased levels of circulating endothelial cells and adhesion molecules in septic patients may therefore reflect factors of importance to parallel changes in the capillary circulation 42, 43, 44, 45, 46…”
Section: The Origins Of Capillary Flow Disturbances or Occlusion In Smentioning
confidence: 99%