Biomarkers of Foods and Nutraceuticals: Applications in Efficacy, Safety, and Toxicity

Gupta, Ramesh C.; Srivastava, Ajay; Sinha, Anita; Lall, Rajiv

doi:10.1007/978-3-030-04624-8_50

Cited by 22 publications

(51 citation statements)

References 180 publications

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“…In recent years, epidemiological studies have shown that the regular consumption of fruits, vegetables, and spices… had a lower incidence of cardiovascular, neurological disorders and others. Functional foods and nutraceuticals have been proven beneficial for the prevention or amelioration of cognitive impairments in degenerative diseases [12].…”

Section: Konzomentioning

confidence: 99%

“…Considering these definitions, we noticed that these products contain bioactive compounds called phytochemicals that are capable of modulating metabolic processes and resulting in the promotion of better health. By having antioxidant, anti-inflammatory, immunomodulatory, adaptogenic, anticancer, and several other health benefits, functional foods and nutraceuticals are used worldwide for the prevention and treatment of chronic diseases such as diabetes, arthritis, cardiovascular and respiratory disorders, neurodegenerative diseases, and cancer [12].…”

Section: Traditional Foods As Functional Foods and Nutraceuticalsmentioning

confidence: 99%

“…Protective effects of phenolic compounds have often been ascribed to their direct antioxidant effect and/or to their anti-inflammatory action [12].…”

Section: Phytochemicalsmentioning

confidence: 99%

“…Oxidative stress is recognized as an important factor in a variety of neurodegenerative diseases, as a mediator of the adverse effects of a number of neurotoxicants, and as a mechanism for age related degenerative processes [12]. Finding alternative and complementary ways to reduce the redox processes might have a beneficial interest in the context of developing countries.…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

“…Flavonoids are a group of phenolic compounds or secondary metabolites that are widely distributed in higher plants and are part of our daily diet. It has been reported that flavonoids exhibit a wide variety of biological effects, including anti-inflammatory, anti oxidant, antiviral, antibacterial, anticarcinogenic, antituberculosis, vasodilatory, and antiallergic activities [12]. They are also cytoprotective in various organs and promote intracellular signals that enhance cell survival, among other benefits.…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

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Traditional Foods as Putative Sources of Antioxidants with Health Benefits in Konzo

Kapepula¹,

Tshala-Katumbay²,

DieudonnéMumba³

et al. 2018

Antioxidants in Foods and Its Applications

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Konzo is a toxico-nutritional neurological disease associated with oxidative damage induced by cyanide poisoning through the ingestion of poorly processed bitter cassava. Dietary uses and patterns, determined using food frequency questionnaires, structured interviews and direct observation in consenting households to Kahemba, the rural area most affected by konzo in the world, showed that the diet of affected population is not varied and largely dependent on cassava (Manihot esculenta Crantz) products. Commonly consumed foodstuffs include herbal teas, mushrooms, spices, vegetables and yams. Phytochemical composition of extracts revealed that they contained flavonoids and phenolic acids as major compounds. All extracts of investigated traditional foods at the concentration range of 0.25-20 μg/mL, displayed high radical scavenging and cellular antioxidant activities using lucigenin on equine neutrophils, related to their phenolic content. The leaves of Manihot esculenta and Manihot glaziovii exhibited the highest antioxidant activity among vegetables. Lippia multiflora is the most active of the herbal teas, Auricularia delicata of mushrooms, Dioscorea alata of yams and Ocimum basilicum of spices. Traditional foods showed more efficient effects on extracellular ROS production and MPO activity. Traditional foods have interesting antioxidant, anti-inflammatory properties and could putatively be used as functional foods or nutraceuticals in the prevention of oxidative damage associated with konzo.* Sesamum angustifolium, one of banned vegetables for konzo households by local traditional medicine [2], is the most active (antioxidant activity) among the vegetables after Manihot species. nd = not determined.

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Section: Konzomentioning

confidence: 99%

Section: Traditional Foods As Functional Foods and Nutraceuticalsmentioning

confidence: 99%

“…Protective effects of phenolic compounds have often been ascribed to their direct antioxidant effect and/or to their anti-inflammatory action [12].…”

Section: Phytochemicalsmentioning

confidence: 99%

Section: Antioxidant Propertiesmentioning

confidence: 99%

Section: Antioxidant Propertiesmentioning

confidence: 99%

See 3 more Smart Citations

Traditional Foods as Putative Sources of Antioxidants with Health Benefits in Konzo

Kapepula¹,

Tshala-Katumbay²,

DieudonnéMumba³

et al. 2018

Antioxidants in Foods and Its Applications

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Therapeutic application of nutraceuticals in diabetic nephropathy: Current evidence and future implications

Dehdashtian

Pourhanifeh

Karim

et al. 2020

Diabetes Metabolism Res

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Summary Diabetes mellitus (DM) is a common metabolic disease which may cause several complications, such as diabetic nephropathy (DN). The routine medical treatments used for DM are not effective enough and have many undesirable side effects. Moreover, the global increased prevalence of DM makes researchers try to explore potential complementary or alternative treatments. Nutraceuticals, as natural products with pharmaceutical agents, have a wide range of therapeutic properties in various pathologic conditions such as DN. However, the exact underlying mechanisms have not been fully understood. The purpose of this review is to summarize recent findings on the effect of nutraceuticals on DN.

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Plant-Based Nutraceuticals

Ramesh

Praveen

2022

Conceptualizing Plant-Based Nutrition

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Biomarkers of Foods and Nutraceuticals: Applications in Efficacy, Safety, and Toxicity

Cited by 22 publications

References 180 publications

Traditional Foods as Putative Sources of Antioxidants with Health Benefits in Konzo

Traditional Foods as Putative Sources of Antioxidants with Health Benefits in Konzo

Therapeutic application of nutraceuticals in diabetic nephropathy: Current evidence and future implications

Plant-Based Nutraceuticals

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