Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism

Liu, Runqiu; Peng, Cong; Jing, Danrong; Xiao, Yangjian; Zhu, Wu; Zhao, Shuang; Zhang, Jianglin; Chen, Xiang; Li, Jie

doi:10.3389/fcimb.2021.703126

Cited by 20 publications

(39 citation statements)

References 56 publications

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“…α-diversity was used to compare the diversity within a sample, and we found that the two groups of microorganisms were statistically different in richness (Chao1 and Observed species) and diversity (Shannon), but not different in evenness (Pielou’s evenness). The α-diversity of the CSU was generally higher than that of the control group, which contradicted earlier research ( Lu et al., 2019 ; Wang et al., 2020 ; Wang et al., 2021 ; Liu et al., 2021 ; Yüksekal et al., 2022 ). Some studies reported that there were significant differences in α-diversity, and the species diversity of chronic urticaria group decreased ( Lu et al., 2019 ; Wang et al., 2020 ); other studies found no significant difference in α-diversity between CSU patients and controls ( Zhang et al., 2021 ; Wang et al., 2021 ).…”

Section: Discussioncontrasting

confidence: 90%

“…This result may be controversial, and we think that it may be related to factors such as sample size, the geographical location of the subjects, eating habits, and research methods. While β-diversity was used to assess diversity across various samples, there was a significant difference between the CSU and NCs group, which is consistent with previous studies ( Lu et al., 2019 ; Wang et al., 2020 ; Wang et al., 2021 ; Liu et al., 2021 ; Zhang et al., 2021 ; Yüksekal et al., 2022 ). Composition analysis of the two groups of samples showed that the relative abundance of Firmicutes increased in the CSU group, while the relative abundance of Bacteroidetes and Proteobacteria decreased, which was similar to the study by Wang et al ( Wang et al., 2021 ), but different from the decreased abundance of Firmicutes in the study by Wang et al ( Wang et al., 2020 ).…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Combined microbiome and metabolome analysis of gut microbiota and metabolite interactions in chronic spontaneous urticaria

Luo

Jin²,

Tao³

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundThe pathogenesis of chronic spontaneous urticaria (CSU) is unclear, and it turned out to be involved in biological processes, such as autoimmunity, autoallergy, inflammation, and coagulation. The gut microbiota plays an important role in immune and inflammatory diseases. However, the relationship between chronic spontaneous urticaria and the gut microbiota remains unknown.MethodsThe stool and serum samples were taken from 15 CSU patients and 15 normal controls. Changes in the composition of gut microbiota and serum metabolism in CSU patients and normal controls were analyzed by 16S ribosomal RNA (rRNA) gene sequencing and untargeted metabolomics.ResultsThe results of 16S rRNA gene sequencing showed that compared with normal controls, CSU patients had increased α-diversity of gut microbiota and significant differences in β-diversity. At the phylum level, the relative abundance of Firmicutes increased and the relative abundance of Bacteroidetes and Proteobacteria decreased in CSU patients compared with healthy controls. At the genus level, six kinds of bacteria were significantly enriched in CSU patients and five in normal controls. Metabolomic analysis revealed altered levels of metabolites such as unsaturated fatty acids and purines. Correlation analysis of gut microbiota and metabolites showed that Lachnospira was negatively correlated with arachidonic acid, and Gemmiger was also negatively correlated with (±)8-HETE.ConclusionThis study suggests that changes in gut microbiota and metabolites may play a role in immune and inflammatory pathways in the pathogenesis of CSU patients.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Combined microbiome and metabolome analysis of gut microbiota and metabolite interactions in chronic spontaneous urticaria

Luo

Jin²,

Tao³

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Immunologic dysfunction and thrombophilia are known key factors in the pathogenesis of SAB (Liu et al, 2021a). A previous study showed that the relative abundance of Actinomyces and Subdoligranulum is closely related to multiple autoimmune diseases, including systemic lupus erythematosus and chronic spontaneous urticaria, suggesting that these bacteria play an important role in the host immune response (Chen B. D. et al, 2021;Liu et al, 2021). The protective effect of Lactococcus on SAB was likely due to lactic acid bacteria reducing autoimmunity and recovering immune homeostasis (Xu et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Causal associations between gut microbiota and adverse pregnancy outcomes: A two-sample Mendelian randomization study

Liu

2022

Front. Microbiol.

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Growing evidence indicates that gut microbiota could be closely associated with a variety of adverse pregnancy outcomes (APOs), but a causal link between gut microbiome and APOs has yet to be established. Therefore, in this study, we comprehensively investigated the relationship between gut microbiota and APOs to identify specific causal bacteria that may be associated with the development and occurrence of APOs by conducting a two-sample Mendelian randomization (MR) analysis. The microbiome genome-wide association study (GWAS) from the MiBioGen consortium was used as exposure data, and the GWAS for six common APOs was used as outcome data. Single-nucleotide polymorphisms (SNPs) that significantly correlated to exposure, data obtained from published GWAS, were selected as instrumental variables (IVs). We used the inverse variance-weighted (IVW) test as the main MR analysis to estimate the causal relationship. The Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) and MR-Egger regression were used to confirm the presence of horizontal pleiotropy and to exclude outlier SNPs. We performed Cochran's Q test to assess the heterogeneity among SNPs associated with each bacterium. The leave-one-out sensitivity analysis was used to evaluate whether the overall estimates were affected by a single SNP. Our analysis shows a causal association between specific gut microbiota and APOs. Our findings offer novel insights into the gut microbiota-mediated development mechanism of APOs.

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“…Gut microbiota involved in various diseases is gradually revealed. Gut microbiota has even become a biomarker for the treatment and diagnosis of some complex diseases, such as bipolar disorder ( 12 ), chronic spontaneous urticaria, and symptomatic dermographism ( 13 ). As summarized in our previous review, the impact of the gut microbiota on host health is mainly achieved through microbial metabolites ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota—metabolites axis in mice

Zhang

Li²,

Qin³

et al. 2022

Front. Nutr.

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C-phycocyanin is a natural protein extracted from Spirulina platensis. We aim to investigate the preventive effect of C-phycocyanin on cisplatin chemotherapy-induced oxidative damage and inflammation. The result showed that C-phycocyanin treatment reduced cisplatin-induced mortality and inflammation including decreased levels of serum IL6, kidney MCP1, and liver IL1β. Furthermore, C-phycocyanin also exerted antioxidant effects on mice, including increased GSH-Px, GGT, and GSH levels in the liver and increased CAT and SOD levels in the kidney. HepG2 cells experiments showed that C-phycocyanin exhibited none of the prevention effects on cisplatin injury. Faecalibaculum showed the greatest reduction among genera after cisplatin treatment, which was related to the enrichment of Romboutsia and Lactobacillus genera. C-phycocyanin treatment reduced the populations of harmful bacteria of Enterococcus faecalis, which was positively correlated with inflammation induced by cisplatin. C-phycocyanin increased the contents of 23-nordeoxycholic acid and β-muricholic acid. Moreover, C-phycocyanin increased amino acid-related metabolites, Nα-acetyl-arginine and trimethyl-lysine contents, and decreased fatty acid esters of hydroxy fatty acids (FAHFAs) contents. In conclusion, C-phycocyanin inhibited inflammation via the 23-nordeoxycholic acid-Enterococcus faecalis-inflammation axis, and enhanced the antioxidant capacity of kidney via Lactobacillus-NRF2 pathway. C-phycocyanin alleviated cisplatin injury via the modulation of gut microbiota, especially Lactobacillus and Enterococcus, as well as regulation of metabolites, especially bile acid and FAHFAs, which highlight the effect of C-phycocyanin and provide a new strategy to prevent cisplatin injury.

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Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism

Cited by 20 publications

References 56 publications

Combined microbiome and metabolome analysis of gut microbiota and metabolite interactions in chronic spontaneous urticaria

Combined microbiome and metabolome analysis of gut microbiota and metabolite interactions in chronic spontaneous urticaria

Causal associations between gut microbiota and adverse pregnancy outcomes: A two-sample Mendelian randomization study

C-phycocyanin alleviated cisplatin-induced oxidative stress and inflammation via gut microbiota—metabolites axis in mice

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