Biomarkers of Human Cardiopulmonary Response After Short-Term Exposures to Medical Laser-Generated Particulate Matter From Simulated Procedures

Abstract

Objective We conducted an exposure chamber study in humans using a simulated clinical procedure lasing porcine tissue to demonstrate evidence of effects of exposure to laser generated particulate matter (LGPM). Methods We measured pre- and post-exposure changes in exhaled nitric oxide (eNO), spirometry, heart rate variability (HRV), and blood markers of inflammation in five volunteers. Results Change in pre- and post-exposure measurements of eNO and spirometry were unremarkable. Neutrophil and lymphocyte counts increased and fibrinogen levels decreased in four of the five subjects. Measures of HRV showed decreases in the standard deviation of normal between beat intervals and sequential five-minute intervals. Conclusion These data represent the first evidence of human physiologic response to LGPM exposure. Further exploration of coagulation effects and HRV are warranted.

Surgical Smoke and Biological Symptoms in Healthcare Professionals and Patients: A Systematic Review

“…3,4,11,12 There was also evidence of histopathological changes in the nasal mucosa of healthcare professionals, 5 and changes in the blood count of neutrophils and lymphocytes. 17 The presence of benzene and toluene in the urine was observed 1,18 regarding organic absorption of toxic substances identified in surgical smoke by patients and healthcare professionals, or even increased exposure levels to formaldehyde and acetaldehyde. 6 The main signs and symptoms identified and their frequency of appearance in the studies which compose the present review are shown in Table 5.…”