Biomarkers of human exposure to ochratoxin A

Scott, Peter

doi:10.1080/02652030500410315

Cited by 92 publications

(73 citation statements)

References 57 publications

(76 reference statements)

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“…OTA was reported in human milk in Norway, Sweden, Germany, Italy, Chile, Australia and Brazil (Scott, 2005;Munoz et al, 2010). Since the mean concentration of OTA detected in the urine of wholly breastfed children (0.19 ng/mL) was essentially the same with those of the fully weaned children (0.16 ng/mL) and partially breastfed children (0.21 ng/mL); there is no doubt that the wholly breastfed infants tend to have the same exposure risk as the fully weaned children.…”

Section: Discussionmentioning

confidence: 99%

Multimycotoxin analysis in urines to assess infant exposure: A case study in Cameroon

Ediage

Mavungu

Song

et al. 2013

Environment International

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Section: Discussionmentioning

confidence: 99%

Multimycotoxin analysis in urines to assess infant exposure: A case study in Cameroon

Ediage

Mavungu

Song

et al. 2013

Environment International

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“…OTA kann als unveränderte Substanz im Plasma/Serum, Urin und Muttermilch nachgewiesen werden [74,75].…”

Section: Auswahl Der Parameterunclassified

“…Weitere Studien insbesondere zur Eliminationskinetik erscheinen nach überein-stimmender Expertenmeinung erforderlich, um OTA im Urin als Marker der inneren Exposition fest zu etablieren. Zusätzlich könnten bisher kaum untersuchte OTA-Metabolite im Urin eine Alternative darstellen [74,75,76].…”

Section: Auswahl Der Parameterunclassified

“…Verschiedene Studien belegen das Vorkommen von OTA in Muttermilch [74,75]. Bei parallelen Bestimmungen von OTA im Serum bzw.…”

Section: Auswahl Der Parameterunclassified

“…Daneben kommen auch die Festphasenextraktion und die Immunoaffinitätschromatographie zum Einsatz. Nach dem Abdampfen des Lö-sungsmittels und Aufnahme in der mobilen Phase erfolgt eine flüssigkeitschroma-tographische Abtrennung mit anschließender Fluoreszenzdetektion (λ ex : 330-340; λ em : 420-470 nm) [74]. Ein auf den genannten Prinzipien beruhendes und bis in den Bereich der umweltbedingten Hintergrundbelastung messendes Standardverfahren zur Bestimmung von OTA wurde kürzlich von der Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe der DFG veröffentlicht [79].…”

Section: Analytikunclassified

See 2 more Smart Citations

Stoffmonographie Ochratoxin A

2014

Bundesgesundheitsbl.

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Ochratoxin A: Developmental and Reproductive Toxicity—An Overview

Malíř

Ostrý

Pfohl‐Leszkowicz

et al. 2013

Birth Defects Research Pt B

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Ochratoxin A (OTA) is nephrotoxic, hepatotoxic, reprotoxic, embryotoxic, teratogenic, neurotoxic, immunotoxic, and carcinogenic for laboratory and farm animals. Male and female reproductive health has deteriorated in many countries during the last few decades. A number of toxins in environment are suspected to affect reproductive system in male and female. OTA is one of them. OTA has been found to be teratogenic in several animal models including rat, mouse, hamster, quail, and chick, with reduced birth weight and craniofacial abnormalities being the most common signs. The presence of OTA also results in congenital defects in the fetus. Neither the potential of OTA to cause malformations in human nor its teratogenic mode of action is known. Exposure to OTA leads to increased embryo lethality manifested as resorptions or dead fetuses. The mechanism of OTA transfer across human placenta (e.g., which transporters are involved in the transfer mechanism) is not fully understood. Some of the toxic effects of OTA are potentiated by other mycotoxins or other contaminants. Therefore, OTA exposure of pregnant women should be minimized. OTA has been shown to be an endocrine disruptor and a reproductive toxicant, with abilities of altering sperm quality. Other studies have shown that OTA is a testicular toxin in animals. Thus, OTA is a biologically plausible cause of testicular cancer in man.

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Biomarkers of human exposure to ochratoxin A

Cited by 92 publications

References 57 publications

Multimycotoxin analysis in urines to assess infant exposure: A case study in Cameroon

Multimycotoxin analysis in urines to assess infant exposure: A case study in Cameroon

Stoffmonographie Ochratoxin A

Ochratoxin A: Developmental and Reproductive Toxicity—An Overview

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