Biomarkers of Inflammation in Allergic Rhinitis

Abstract

Biomarkers of Inflammation in Allergic Rhinitis A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Allergic rhinitis is one of the most common atopic diseases. The skin prick test and the allergen-specific IgE antibody test are used for its diagnosis. The aim of this study was to identify the presence of allergic inflammatory parameters with prognostic value, which are easily accessible, simple and inexpensive, to make them available for clinical use. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This study included people with and without allergic rhinitis between the ages of 18-55 years who were admitted to the Internal Medicine and Allergy and Clinical Immunology polyclinics. Those without a known disease were included in the healthy group. People who did not receive any immunotherapy, were identified as allergic by skin prick tests and had no other disease were included in the allergic rhinitis group. Data were obtained retrospectively by screening the patients' files, and hence patient approval was not required in this study. R Re es su ul lt ts s: : The allergic rhinitis group comprised 114 (62.6%) females and 68 (37.4%) males, with a mean age of 31.37±9.89 years. The healthy group consisted of 50 (56.2%) males and 39 (43.8%) females, with a mean age of 31.93±10.87 years. In the allergic rhinitis group, while the eosinophil count (p=0.042), eosinophil-lymphocyte ratio (ELR) (p=0.007) and plateletlymphocyte ratio (PLR) (p=0.007) were found to be significantly high, the median platelet volume (MPV) was found to be significantly low (p<0.001). MPV measurements were significantly lower in the allergic rhinitis group (p<0.001). For MPV, the sensitivity was 64.84%, the specificity was 65.17%, the positive predictive value (PPV) was 79.20% and the negative predictive value (NPV) was 47.50%. For PLR (p=0.005), the sensitivity was 61.54%, the specificity was 59.55%, the PPV was 75.70% and the NPV was 43.10%. For ELR (p=0.005), the sensitivity was 48.90%, the specificity was 74.16%, the PPV was 79.50% and the NPV was 41.50%. C Co on nc cl lu us si io on n: : MPV, PLR and ELR do not directly indicate a single disease. We suggest that it is particularly important in primary health care to take a complete blood count in clinical practice to direct the patient to an allergy centre. Skin prick testing and allergen-specific IgE screening will be appropriate to confirm allergic rhinitis in suspected cases. We believe that a more extensive study is needed in this regard. K Ke ey yw wo or rd ds s: : Rhinitis, allergic, perennial; blood platelets; eosinophils Ö ÖZ ZE ET T A Am ma aç ç: : Allerjik rinit en sık rastlanılan atopik hastalıktır. Tanısında deri prick ve allerjen spesifik IgE testleri kullanılır. Çalışmanın amacı allerjik inflamasyonu gösteren ulaşılabilir, kolay, ucuz, prognostik olarak da değer taşıyan parametrelerin varlığını saptamak ve kullanıma sunulmasına katkıda bulunmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : İç Hastalıkları ile Allerji ve Klinik İmmunoloji poliklinikleri...