Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation

Jabati, Sallu; Fareed, Jawed; Liles, Jeffrey; Otto, Abigail; Hoppensteadt, Debra; Bontekoe, J. S.; Phan, Trung Nam; Syed, Mushabbar A.

doi:10.1177/1076029618761006

Cited by 28 publications

(24 citation statements)

References 30 publications

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“…Biomarker profiles can predict AF risk and the prognosis after AF ablation (55,56). Nevertheless, the initiating and sustaining factors for AF may be different, and inflammation has been associated with both.…”

Section: Inflammatory Biomarkers Are Correlated With Afmentioning

confidence: 99%

Evidence for Inflammation as a Driver of Atrial Fibrillation

Zhou

Dudley

2020

Front. Cardiovasc. Med.

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Atrial fibrillation (AF) is one of the most common types of arrhythmias and increases cardiovascular morbidity and mortality. Current therapeutic approaches to AF that focus on rhythm control have high recurrence rates and no life prolongation value. While possible explanations include toxicity of current therapies, another likely explanation may be that current therapies do not address fundamental mechanisms of AF initiation and maintenance. Inflammation has been shown to affect signaling pathways that lead to the development of AF. This paper reviews the roles of inflammation in the occurrence, development, and mechanisms of AF and reviews the therapeutic implications of the correlation of inflammation and AF.

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Section: Inflammatory Biomarkers Are Correlated With Afmentioning

confidence: 99%

Evidence for Inflammation as a Driver of Atrial Fibrillation

Zhou

Dudley

2020

Front. Cardiovasc. Med.

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“…Previous studies report elevated levels of these circulating biomarkers that reflect inflammation, cardiac remodeling and fibrosis biomarkers in AF patients coexisting with hypertension, diabetes, heart failure and myocardial infarction [ 20 – 24 ]. Inflammation is found to be involved in the development and perpetuation of AF and AF-related thrombosis [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular magnetic resonance-determined left ventricular myocardium impairment is associated with C-reactive protein and ST2 in patients with paroxysmal atrial fibrillation

Zhao

Zhang

et al. 2021

Journal of Cardiovascular Magnetic Resonance

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Background Myocardial strain assessed with cardiovascular magnetic resonance (CMR) feature tracking can detect early left ventricular (LV) myocardial deformation quantitatively in patients with a variety of cardiovascular diseases, but this method has not yet been applied to quantify myocardial strain in patients with atrial fibrillation (AF) and no coexistent cardiovascular disease, i.e., the early stage of AF. This study sought to compare LV myocardial strain and T1 mapping indices in AF patients and healthy subjects, and to investigate the associations of a portfolio of inflammation, cardiac remodeling and fibrosis biomarkers with LV myocardial strain and T1 mapping indices in AF patients with no coexistent cardiovascular disease. Methods The study consisted of 80 patients with paroxysmal AF patients and no coexistent cardiovascular disease and 20 age- and sex-matched healthy controls. Left atrial volume (LAV), LV myocardial strain and native T1 were assessed with CMR, and compared between the AF patients and healthy subjects. Biomarkers of C-reactive protein (CRP), transforming growth factor beta-1 (TGF-β1), collagen III N-terminal propeptide (PIIINP), and soluble suppression of tumorigenicity 2 (sST2) were obtained with blood tests, and compared between the AF patients and healthy controls. Associations of these biomarkers with those CMR-measured parameters were analyzed for the AF patients. Results For the CMR-measured parameters, the AF patients showed significantly larger LAV and LV end-systolic volume, and higher native T1 than the healthy controls (max P = 0.027). The absolute values of the LV peak systolic circumferential strain and its rate as well as the LV diastolic circumferential strain rate were all significantly reduced in the AF patients (all P < 0.001). For the biomarkers, the AF patients showed significantly larger CRP (an inflammation biomarker) and sST2 (a myocardium stiffness biomarker) than the controls (max P = 0.007). In the AF patients, the five CMR-measured parameters of LAV, three LV strain indices and native T1 were all significantly associated with these two biomarkers of CRP and sST2 (max P = 0.020). Conclusions In patients with paroxysmal AF and no coexistent cardiovascular disease, LAV enlargement and LV myocardium abnormalities were detected by CMR, and these abnormalities were associated with biomarkers that reflect inflammation and myocardial stiffness.

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“…CRP is a sensitive but non-specific marker of systemic inflammation that is associated with atherosclerotic cardiovascular disease risk [32]. Plasma CRP has been reported to increase as function of AF persistence [33] and to predict future development of AF [34]. Here, we measured plasma CRP as a control biomarker of inflammation to evaluate whether changes in plasma ET-1 are specific for AF secondary to hyperthyroidism.…”

Section: Discussionmentioning

confidence: 99%

Plasma endothelin-1 levels are increased in atrial fibrillation patients with hyperthyroidism

et al. 2018

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BackgroundEndothelin-1 (ET-1) is a potent vasoconstrictor, mitogen and inflammatory factor that may contribute to development of atrial fibrillation (AF). Plasma ET-1 levels are increased in hyperthyroid patients, but studies evaluating its relation to AF development in hyperthyroid patients are lacking.ObjectiveThe present study seeks to evaluate the relation of plasma ET-1 to AF development as a function of thyroid status.MethodsBlood samples from euthyroid patients (n = 41), hypothyroid (n = 61), hyperthyroid (n = 41), AF with hyperthyroidism (n = 9), and euthyroid AF (n = 10) patients were collected. Plasma ET-1, CRP, and thyroid hormone levels were measured and compared between groups.ResultsPlasma ET-1 levels were higher in hyperthyroid and euthyroid AF patients> hyperthyroid-non-AF > hypo and euthyroid non-AF patients. Plasma ET-1 levels positively correlated with free T3 and T4 levels, and negatively with TSH levels. By multivariate analysis, plasma ET-1 was positively associated with AF, hyperthyroidism, and age. Plasma CRP did not vary by study group in either univariate or multivariate analyses.ConclusionPlasma ET-1 is associated with AF, elevated in hyperthyroid patients and positively correlated with thyroid hormone levels, suggesting that hyperthyroidism may increase ET-1 expression and release. This study may guide development of novel predictors of AF associated with hyperthyroidism, and may help to personalize therapy in hyperthyroid patients.

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Biomarkers of Inflammation, Thrombogenesis, and Collagen Turnover in Patients With Atrial Fibrillation

Cited by 28 publications

References 30 publications

Evidence for Inflammation as a Driver of Atrial Fibrillation

Evidence for Inflammation as a Driver of Atrial Fibrillation

Cardiovascular magnetic resonance-determined left ventricular myocardium impairment is associated with C-reactive protein and ST2 in patients with paroxysmal atrial fibrillation

Plasma endothelin-1 levels are increased in atrial fibrillation patients with hyperthyroidism

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