Biomarkers of lead exposure in auto-mechanics in Abeokuta, Nigeria

Dosumu, Oluwatosin Adebisi; Onunkwor, Beno; Odukoya, O.O.; Arowolo, T. A.; Ademuyiwa, Oladipo

doi:10.5414/tep22185

Cited by 11 publications

(9 citation statements)

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“…Blood lead analysis was performed using atomic absorption spectrophotometry. Details of this have been given elsewhere [13,14]. …”

Section: Methodsmentioning

confidence: 99%

“…While lead exposure studies is a well-trodden subject in economically advanced countries [17-22], few published reports exist about lead poisoning and its associated effects in developing countries like Nigeria [12-14,16]. …”

Section: Introductionmentioning

confidence: 99%

“…We have previously reported on chronic lead poisoning and its associated biochemical effects in auto-mechanics, petrol station attendants and some other artisans in Abeokuta, Nigeria [12-14,16]. To the best of our knowledge, data regarding the distribution of blood lipids and the risk of cardiovascular disease associated with this distribution in those who are occupationally exposed to lead in Nigeria, are lacking.…”

Section: Introductionmentioning

confidence: 99%

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Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria

et al. 2005

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In order to investigate the effects of lead exposure on risk of cardiovascular disease during occupational exposure to this metal, plasma cholesterol and its fractions as high-density liporotein (HDL), low-density liporotein (LDL) and triglyceride were determined in various artisans in Abeokuta, Nigeria who have been shown to be occupationally exposed to lead and these were related to blood lead levels. Increased risk of cardiovascular disease was observed in the artisans. Total cholesterol in the artisans was between 1.5 and 2.0 times higher in the artisans than that present in controls while LDL cholesterol was between 1.6 and 2.4 times higher in the artisans when compared with control subjects [p < 0.001]. HDL cholesterol and triglyceride levels were not affected [p > 0.05]. A significant positive correlation was observed between blood lead and total cholesterol on one hand [r = 0.372; p = 3.0 × 10 -5 ] and blood lead and LDL cholesterol on the other hand [r = 0.283; p = 0.001]. LDL/HDL cholesterol ratio was also higher in the artisans when compared with control. Blood pressure (systolic and diastolic) and other anthropometric parameters were not significantly different between the artisans and the control subjects [p > 0.05]. Results suggest that lead exposure increases cholesterol synthesis and transport to peripheral tissues whereas reverse cholesterol transport to the liver is not affected.

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“…Blood lead analysis was performed using atomic absorption spectrophotometry. Details of this have been given elsewhere [13,14]. …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria

et al. 2005

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“…Many studies have examined alternative biomarkers, but the debate is still open on their reliability [25][26][27][28]. Regarding the use of PbU instead of PbB, several authors agree on a significant correlation between these two biomarkers when the biomonitoring is performed on workers exposed to high levels of Pb pollution [27][28][29][30][31][32], whereas caution is advised when the sample consists of subjects exposed to environmental pollution [28,30]. In fact, some studies report a non-significant correlation between PbB and PbU in these subjects [33], especially when the PbB level is below 10 μg/dL [29].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Association between Biomarkers of Lead Exposure in Sardinian Children (Italy)

Sanna

Micco

Vallascas

2011

Biol Trace Elem Res

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The aim of this work is to verify whether there are statistically significant correlations between the concentrations of lead in blood, urine, and hair in children. The sample collected in 2007 consists of 163 children of both sexes from 11-14-year-olds, living in three municipalities of Sardinia (Italy). Inductively coupled plasma atomic mass spectrometry has been used in the determination of lead concentration in biological material. For the overall sample, there is a non-significant partial correlation among the three matrices. However, for subjects with blood lead levels ≥5 μg/dL, there is a significant positive partial correlation between the lead levels in blood and hair, but not between blood and urine or between urine and hair. The results suggest that blood is the preferred biomarker to ascertain lead exposure in human populations, whereas hair can be used as a tool screening when an area is exposed to medium or high lead pollution.

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“…Lead has been proven to produce a series of adverse effects on numerous organs and biochemical indices (Gurer and Ercal, 2000;Chen et al, 2003;Flora et al, 2004;Ademuyiwa et al, 2005;Dosumu et al, 2005;Choudhary et al, 2007). The adverse effects can be hematologic, reproductive, neurobehavioral, nephrotoxic, cytotoxic and cardiovascular (Patra et al, 2000;Moreira et al, 2001;Ademuyiwa et al, 2005;Diamond, 2005;Patil et al, 2006;Ait Hamadouche et al, 2009a;Olympio et al, 2009;Raafat et al, 2009;Ponce-Canchihuaman, 2010;Harishekar and Kiran, 2011;Mrugesh et al, 2011;Patra et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Lead induced dyslipidemia: The comparative effects of ascorbate and chelation therapy

Ugbaja¹,

Onunkwor²,

Omoniyi³

2013

Afr. J. Biotechnol.

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To investigate the comparative effects of ascorbate and chelating agents on some markers of lipid metabolism in lead exposed rats, 35 male Wistar rats were used. They were grouped randomly into five (n=7); 28 of which were administered 75 mg/kg body weight lead acetate (PbAc) orally for 14 days after which their blood samples were assayed for lead. Three of the groups were further administered 30 mg/kg body weight D-penicillamine (D-pen), 30 mg/kg body weight succimer (DMSA) and 500 mg/kg body weight ascorbate (Asc) daily orally, respectively. The control group was however administered normal saline. The blood lipid profiles were determined spectrophotometrically. Lead exposure resulted in significant dyslipidemia (p < 0.05), characterized by 50% hypercholesterolemia and hypertriglyceridemia and 132% hyperphospholipidemia (plasma) while in the red blood cells, hypocholesterolemia and hypophospholipidemia were observed. During the therapeutic doses, the groups administered chelating agents and Asc showed a significant amelioration in the plasma and red blood cell levels of total cholesterol, triacylglycerols and phospholipids in the order, DMSA > Asc > Dpen. Decrease in blood lead levels after therapy indicated that the chelating agents have an advantage over Asc. The study indicates that administration of the antioxidant, Asc may not be more efficacious than the chelating agents but could be a cheaper and more convenient therapy for lead toxicity.

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Biomarkers of lead exposure in auto-mechanics in Abeokuta, Nigeria

Cited by 11 publications

References 0 publications

Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria

Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria

Evaluation of Association between Biomarkers of Lead Exposure in Sardinian Children (Italy)

Lead induced dyslipidemia: The comparative effects of ascorbate and chelation therapy

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