Biomarkers of Mn exposure in humans

Smith, Donald R.; Gwiazda, R.; Bowler, Rosemarie M.; Roels, Harry; Park, Robert; Taicher, Christopher; Lucchini, Roberto

doi:10.1002/ajim.20506

Cited by 153 publications

(142 citation statements)

References 56 publications

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“…Mn-B and urinary Mn concentration (Mn-U) have both been used to discriminate occupationally exposed from nonexposed subjects. However, Mn-U is not a reliable biomarker because the metal is mainly eliminated through the biliary system, Mn-U is highly variable, subject to contamination and does not correlate with airborne Mn in exposed populations (Apostoli et al 2000;Smith et al 2007). Plasma Mn is only 6% of whole-blood Mn content and is considered to have very limited utility as a biomarker of Mn load (Smith et al 2007).…”

Section: Diagnosismentioning

confidence: 99%

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

et al. 2009

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Abstract:The purpose of this review is to highlight recent advances in the neuropathology associated with Mn exposures. We commence with a discussion on occupational manganism and clinical aspects of the disorder. This is followed by novel considerations on Mn transport (see also chapter by Yokel, this volume), advancing new hypotheses on the involvement of several transporters in Mn entry into the brain. This is followed by a brief description of the effects of Mn on neurotransmitter systems that are putative modulators of dopamine (DA) biology (the primary target of Mn neurotoxicity), as well as its effects on mitochondrial dysfunction and disruption of cellular energy metabolism. Next, we discuss inflammatory activation of glia in neuronal injury and how disruption of synaptic transmission and glial-neuronal communication may serve as underlying mechanisms of Mn-induced neurodegeneration commensurate with the cross-talk between glia and neurons. We conclude with a discussion on therapeutic aspects of Mn exposure. Emphasis is directed at treatment modalities and the utility of chelators in attenuating the neurodegenerative sequelae of exposure to Mn. For additional reading on several topics inherent to this review as well as others, the reader may wish to consult Aschner and Dorman (Toxicological Review 25:147-154, 2007) and Bowman et al. (Metals and neurodegeneration, 2009).

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Section: Diagnosismentioning

confidence: 99%

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

et al. 2009

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“…A recent meta-analysis showed these associations are in general only observed at higher exposure levels above ~10 µg m −3 (Baker et al, 2014). However, even in studies with positive associations, blood and urine have not proven to be practical biomarkers due to little variability in biomarker concentrations over a wide range of air exposures (Smith et al, 2007). In addition, associations between Mn in blood or urine and inhaled Mn at an individual level may be masked by dietary intake, because the daily dietary intake of Mn is on average higher than the daily airborne Mn intake of welders (Greger, 1998; Agency for Toxic Substances and Disease Registry, 2012).…”

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confidence: 99%

Hair Manganese as an Exposure Biomarker among Welders

Reiss

Simpson

Baker

et al. 2015

ANNHYG

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Quantifying exposure and dose to manganese (Mn) containing airborne particles in welding fume presents many challenges. Common biological markers such as Mn in blood or Mn in urine have not proven to be practical biomarkers even in studies where positive associations were observed. However, hair Mn (MnH) as a biomarker has the advantage over blood and urine that it is less influenced by short-term variability of Mn exposure levels because of its slow growth rate. The objective of this study was to determine whether hair can be used as a biomarker for welders exposed to manganese. Hair samples (1 cm) were collected from 47 welding school students and individual air Mn (MnA) exposures were measured for each subject. MnA levels for all days were estimated with a linear mixed model using welding type as a predictor. A 30-day time-weighted average MnA (MnA 30d ) exposure level was calculated for each hair sample. The association between MnH and MnA 30d levels was then assessed. A linear relationship was observed between log-transformed MnA 30d and log-transformed MnH. Doubling MnA 30d exposure levels yields a 20% (95% confidence interval: 11-29%) increase in MnH. The association was similar for hair washed following two different wash procedures designed to remove external contamination. Hair shows promise as a biomarker for inhaled Mn exposure given the presence of a significant linear association between MnH and MnA 30d levels.

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“…It has been proposed that Mg is central in the cell cycle, and that its deficiency is an important conditioner in precancerous cell transformation. Also, at high levels, magnesium can cause damage to the brain, liver, kidneys, and the developing foetus (Smith et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Serum Levels of Magnesium and Manganese among Pregnant Women at Central Hospital, Agbor, South-South Nigeria

Osadolor¹,

Omogiade²

2016

Journal of Applied Sciences and Environmental Management

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Pregnant women in developing countries have been reported to consume diets with low density of minerals and essential trace elements. Therefore, this study aims to assess the serum levels of magnesium and manganese and its trimester correlates among pregnant women in Ika community of Delta state, Nigeria. An analytical cross-sectional study was conducted to assess the serum levels of magnesium and manganese among 64 apparently healthy pregnant and age matched 25 healthy non-pregnant women attending antenatal clinic at obstetrics and gynaecology unit of central hospital Agbor. The mean serum levels of manganese increased with increase in gestational age while hypomagnesaemia 12.24ug/dl was observed in 60 (93.8%) of the pregnant women with a larger preponderance in the second trimester There was significant difference between the serum level of manganese in pregnant women compared to non-pregnant women (p<0.001). There were no statistical significance between the serum levels of these trace elements and occupation, nature of dietary intake, age of participants and trimester of pregnancy.We observed an increase in the mean serum levels of manganese with trimester progression while a high prevalence rate (93.8%) of magnesium deficiency among pregnant women was noted in this study. Maximal awareness (advocacy) should therefore be given to pregnant women on the need for adequate dietary intake and supplementation to avoid the complications associated with deficiency of this nutrient. © JASEM http://dx.doi.org/10.4314/jasem.v19i4.6

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Biomarkers of Mn exposure in humans

Cited by 153 publications

References 56 publications

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

Hair Manganese as an Exposure Biomarker among Welders

Assessment of Serum Levels of Magnesium and Manganese among Pregnant Women at Central Hospital, Agbor, South-South Nigeria

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