Biomarkers of oxidative damage and antioxidant enzyme activities in pre-dialysis Balkan endemic nephropathy patients

Pavlović, Dragana; Savić-Radojević, Ana; Plješa-Ercegovac, Marija; Radić, Tanja; Ristić, Slavica; Ćorić, Vesna; Matić, Marija; Simić, Tatjana; Djukanović, Ljubica

doi:10.1007/s11255-015-1192-9

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Oxidant products include ROS (such as superoxide and hydroxyl radical) and reactive nitrogen species (such as nitric oxide (NO)), while antioxidant molecules include Vit C and E, glutathione, and antioxidant enzymes [ 9 ]. Oxidative stress in CKD patients is mediated by several factors such as chronic inflammation, low-molecular-weight uremic toxins, elevated homocysteine level, nutritional inadequacy, and anemia [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of the Hydroalcoholic Extract of Watercress on the Levels of Protein Carbonyl, Inflammatory Markers, and Vitamin E in Chronic Hemodialysis Patients

Sedaghattalab

Razazan

Shahpari

et al. 2021

Biochemistry Research International

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Introduction. Chronic kidney disorder is a main public health concern. Inflammatory processes and oxidative stress are common in end-stage renal disease patients. We aimed to evaluate the effect of the hydroalcoholic extract of watercress (WC) on the inflammatory cytokines and protein carbonyl (PCO) contents in chronic hemodialysis patients. Methods. This was a double-blind randomized clinical trial performed on 46 hemodialysis patients. The participants were randomly divided into two groups: intervention group (500 mg hydroalcoholic extract of WC every day for 4 weeks) and control group (500 mg of white flour every night for 4 weeks). The blood samples were taken to determine the levels of vitamin E, PCO, and inflammatory cytokines at baseline and the end of treatment. Results. Forty-five patients completed the study (22 patients in the intervention group and 23 patients in the control group). There was a significant reduction in the PCO level (20.33 ± 4.40 vs. 15.06 ± 6.41, P = 0.001 ) in the intervention group; also, this change was statistically significant relative to the control group. Furthermore, there were significant reductions in hs-CRP (8953.30 ± 5588.06 vs. 7249.86 ± 5091.62, P = 0.007 ) and IL-6 (60.10 (55.99, 73.10) vs. 55.21 (53.39, 60.48), P = 0.050 ) in the intervention group, but these changes were not significant in comparison with the control group. Conclusion. We conclude that the hydroalcoholic extract of WC reduced the PCO content in hemodialysis patients via inhibition of protein oxidation. Although WC administration had caused a significant reduction in IL-6 and CRP levels, these differences were not statistically significant relative to the control group. Further research is needed to identify the antioxidant and anti-inflammatory effects of WC in hemodialysis patients.

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Section: Discussionmentioning

confidence: 99%

The Effect of the Hydroalcoholic Extract of Watercress on the Levels of Protein Carbonyl, Inflammatory Markers, and Vitamin E in Chronic Hemodialysis Patients

Sedaghattalab

Razazan

Shahpari

et al. 2021

Biochemistry Research International

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“…Níveis elevados de EROs no corpo, podem produzir danos celulares, pois interagem com biomoléculas de proteína, lipídio e ácidos nucleicos e assim têm efeito negativo sobre a função e estrutura dos tecidos (DOBASHI et al, 2000). O EO na DRC tem origem multifatorial que pode estar associado ao estado inflamatório crônico característico da DRC (KOBAYASHI et al, 2005;Janiques et al, 2013), aos efeitos das toxinas urêmicas, anemia, depleção de vitamina E, aumento na formação de produtos finais de glicosilação (AGE) e proteínas de oxidação avançada, diminuição da expressão da glutationa peroxidase e elevação do nível de homocisteína e a própria acidose metabólica (PAVLOVIĆ et al, 2016;GÜNAL;USTÜNDAĞ;GÜNAL, 2013;ROOZBEH et al, 2011;ATAMER et al, 2008;FRASSETTO, SEBASTIAN, 2012).…”

Section: Estresse Oxidativounclassified

Substituição parcial de proteína animal por vegetal na dieta de portadores de doença renal crônica: efeitos sobre a acidez em sangue e urina

Souza¹

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The diet has a strong influence on the formation of the acid load in the metabolism of patients with CKD, and this is a factor that can influence the severity of metabolic acidosis. It is a condition commonly found in more advanced stages of CKD. Vegetable proteins, such as textured soy protein (PTS), could provide a lower acid charge formation and, because of their content of isoflavones, considered antioxidants, would contribute to the improvement of metabolic stress. The objective of this study was to evaluate the effects of replacing animal protein source to plant source (soybean) for one week and analyze the blood and urine parameters of acidosis in patients with CKD. We evaluated 28 patients with CKD stages 3, 4 and 5 before and after replacing animal protein sources of the main meal, either lunch or dinner, with PTS over 7 days. Before and after the intervention it was evaluated: feed intake per records, Load Acid Potential Food (CAPA), clinical routines, anthropometry (weight, height and BMI), body composition by bioelectrical impedance multifrequency spectroscopy (BIS), blood and urine parameters (Bicarbonate and urinary pH) and oxidative stress markers (CAT and AOPP) Mann-Whitney non-parametric tests were used to analyze the results, as well as the Spearman's correlation tests to evaluate associations between the variables. The p value <0.05 was considered for statistical significance. We found that in one week of intervention with PTS there was a significant increase in BIC markers and blood pH, as well as urinary pH. Most of the patients were not in the state of metabolic acidosis. The CAT oxidative stress marker showed 11 improvement, but AOPP showed no significant increase. Regarding body composition, there was a decrease in weight and an increase in the hyper hydration markers, but an increase in fat free mass and fat mass. These results show that the decrease of CAPA in the diet and the inclusion of the PTS can generate an improvement in metabolic acidosis and oxidative stress, consolidating the dietary management using plant protein inclusion and this can be an important nutritional approach in the treatment of patients with DRC.

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How common is Balkan endemic nephropathy among immigrants in endemic regions?

Đukanović

Račić

Marić³

et al. 2018

Int Urol Nephrol

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Biomarkers of oxidative damage and antioxidant enzyme activities in pre-dialysis Balkan endemic nephropathy patients

Cited by 6 publications

References 35 publications

The Effect of the Hydroalcoholic Extract of Watercress on the Levels of Protein Carbonyl, Inflammatory Markers, and Vitamin E in Chronic Hemodialysis Patients

The Effect of the Hydroalcoholic Extract of Watercress on the Levels of Protein Carbonyl, Inflammatory Markers, and Vitamin E in Chronic Hemodialysis Patients

Substituição parcial de proteína animal por vegetal na dieta de portadores de doença renal crônica: efeitos sobre a acidez em sangue e urina

How common is Balkan endemic nephropathy among immigrants in endemic regions?

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