Biomarkers of oxidative-stress and inflammation in exhaled breath condensate from hospital cleaners

Casimirri, Enrico; Stendardo, Mariarita; Bonci, Melissa; Andreoli, Roberta; Bottazzi, Barbara; Leone, Roberto; Schito, Michela; Vaccari, A; Papi, Alberto; Contoli, Marco; Corradi, Massimo; Boschetto, Pierà

doi:10.3109/1354750x.2015.1118541

Cited by 16 publications

(14 citation statements)

References 31 publications

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“…Three studies investigating FeNO in exhaled breath condensate after acute (preshift versus postshift) exposure to cleaning products containing chlorine did not found a significant difference between cleaners and controls. 44 46 48 Of note, in one of them, a positive association of exposure to cleaning products with biomarkers of oxidative stress and inflammation (ie, malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrates (NO3-), in the exhaled breath condensate was found 48 (table 3).…”

Section: Other Health Outcomesmentioning

confidence: 99%

Cleaning products and respiratory health outcomes in occupational cleaners: a systematic review and meta-analysis

et al. 2020

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There is consistent evidence of increased respiratory symptoms in occupational cleaners; however, uncertainty remains on type of respiratory health effects, underlying causal agents, mechanisms and respiratory phenotypes. We aimed to conduct a systematic review and if possible, a meta-analysis of the available literature to characterise and quantify the cleaning-related respiratory health effects. We searched MEDLINE and EMBASE databases and included studies that evaluated the association of any respiratory health outcome with exposure to cleaning occupation or products in occupational cleaners. A modified GRADE was used to appraise the quality of included studies. We retrieved 1124 articles, and after applying our inclusion criteria, 39 were selected for the systematic review. We performed a meta-analysis of the 21 studies evaluating asthma which showed a 50% increased pooled relative risk in cleaners (meta-relative risk (RR)=1.50; 95% CI 1.44 to 1.56). Population-based cross-sectional studies showed more stable associations with asthma risk. No evidence of atopic asthma as dominant phenotype emerged. Also, we estimated a 43% increased risk (meta-RR=1.43; 95% CI 1.31 to 1.56) of chronic obstructive pulmonary disease. Evidence for associations with bronchial-hyper-responsiveness, lung function decline, rhinitis, upper and lower respiratory tract symptoms was weaker. In our systematic review and meta-analysis, we found that working as a cleaner is associated with an increased risk of reversible and even irreversible obstructive airway diseases. All studies lacked quantitative exposure assessment to cleaning products; this would help elucidate underlying causal agents and mechanisms. Exposure control and respiratory surveillance among cleaners is warranted to prevent the associated respiratory health burden. Trial registration number: CRD4201705915.

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Section: Other Health Outcomesmentioning

confidence: 99%

Cleaning products and respiratory health outcomes in occupational cleaners: a systematic review and meta-analysis

et al. 2020

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“…Oxidative stress has been suggested as one of the mechanisms for the impact of inhaled irritant cleaning products on the airway epithelium [44,59]. In accordance with this hypothesis, an Italian study of hospital cleaners reported that potential biomarkers of oxidative stress in exhaled breath condensate were higher in cleaners compared to control workers, while Fractional exhaled Nitric Oxide levels were similar in both groups [47].…”

Section: Mechanismsmentioning

confidence: 82%

“…Irritant-induced asthma or rhinitis can be caused by a single high level (accidental) exposure to irritants or by chronic, lower level ('daily-life') exposure to irritants [30,45,46]. Chronic exposure to inhaled irritants from DCPs may cause injury of the airway epithelium, oxidative stress and neutrophilic airway inflammation [47][48][49], which are also relevant to COPD pathogenesis. Among all cleaning agents reported as likely causative agents of occupational asthma in THOR surveillance network, 15 low molecular weight organic compounds were identified [13].…”

Section: Mechanismsmentioning

confidence: 99%

Cleaners and airway diseases

Dumas¹

2020

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review: Evidence for adverse respiratory effects of occupational exposure to disinfectants and cleaning products (DCPs) has grown in the last two decades. The relationship between DCPs and asthma is well-documented, but questions remain regarding specific causal agents. Beyond asthma, associations between DCPs and COPD or chronic rhinitis are plausible and have been examined recently. The purpose of this review is to summarize recent advances on the effect of occupational exposure to DCP and chronic airway diseases. Recent findings:Recent epidemiological studies have often focused on healthcare workers and are characterized by efforts to improve assessment of exposure to specific DCPs. Despite increasing knowledge on the effect of DCPs on asthma, the burden of work-related asthma caused by DCPs has not decreased in the past decade, emphasizing the need to strengthen prevention efforts. Novel data suggest an association between occupational exposure to DCPs and other chronic airway diseases, such as rhinitis, COPD and poor lung function.Summary: Epidemiological and experimental data showed that many chemicals contained in DCPs are likely to cause airway damages, indicating that prevention strategies should target multiple products. Further research is needed to evaluate the impact of DCPs exposure on occupational airway diseases beyond asthma.

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“…Nitrate and nitrite anions have been considered by a number of researchers as stable metabolites of nitric oxide and are present in living organisms in micromolar amounts [ 58 ]. In addition, a different, but a significant amount of these ions comes from food and water.…”

Section: Introductionmentioning

confidence: 99%

The State of the Nitric Oxide Cycle in Respiratory Tract Diseases

Soodaeva

Klimanov

Kubysheva

et al. 2020

Oxidative Medicine and Cellular Longevity

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This review describes the unique links of the functioning of the nitric oxide cycle in the respiratory tract in normal and pathological conditions. The concept of a nitric oxide cycle has been expanded to include the NO-synthase and NO-synthase-independent component of its synthesis and the accompanying redox cascades in varying degrees of reversible reactions. The role of non-NO-synthase cycle components has been shown. Detailed characteristics of substrates for the synthesis of nitric oxide (NO) in the human body, which can be nitrogen oxides, nitrite and nitrate anions, and organic nitrates, as well as nitrates and nitrites of food products, are given. The importance of the human microbiota in the nitric oxide cycle has been shown. The role of significant components of nitrite and nitrate reductase systems in the nitric oxide cycle and the mechanisms of their activation and deactivation (participation of enzymes, cofactors, homeostatic indicators, etc.) under various conditions have been determined. Consideration of these factors allows for a detailed understanding of the mechanisms underlying pathological conditions of the respiratory system and the targeting of therapeutic agents. The complexity of the NO cycle with multidirectional cascades could be best understood using dynamic modeling.

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Biomarkers of oxidative-stress and inflammation in exhaled breath condensate from hospital cleaners

Abstract: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.

Cited by 16 publications

References 31 publications

Cleaning products and respiratory health outcomes in occupational cleaners: a systematic review and meta-analysis

Cleaning products and respiratory health outcomes in occupational cleaners: a systematic review and meta-analysis

Cleaners and airway diseases

The State of the Nitric Oxide Cycle in Respiratory Tract Diseases

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