Biomarkers of Oxidative Stress in Acute and Chronic Diseases

Massaccesi, Luca; Balistreri, Carmela Rita

doi:10.3390/antiox11091766

Cited by 2 publications

(2 citation statements)

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“…Of note also is autophagy, although the related mechanisms remain indefinable, and further investigation is necessary [9]. Interesting also is the contribution of ferroptosis, a novel cell death form caused by iron-dependent lipid peroxidation [10][11][12] and associated with the pathogenesis of many diseases, such as ND. Such has led some to suppose that variations in the iron metabolism's homeostasis, the consequent induction of oxidative stress, and the related inflammation in the CNS is involved in the onset of ferroptosis and neuronal health [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Interesting also is the contribution of ferroptosis, a novel cell death form caused by iron-dependent lipid peroxidation [10][11][12] and associated with the pathogenesis of many diseases, such as ND. Such has led some to suppose that variations in the iron metabolism's homeostasis, the consequent induction of oxidative stress, and the related inflammation in the CNS is involved in the onset of ferroptosis and neuronal health [10][11][12]. In such a process, the apelinergic system, mediated by ELA/APJ signaling, has also been recently documented to participate in this regulation [13].…”

Section: Introductionmentioning

confidence: 99%

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Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

Balistreri,

Monastero

2023

Brain Sciences

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The term “neuroinflammation” defines the typical inflammatory response of the brain closely related to the onset of many neurodegenerative diseases (NDs). Neuroinflammation is well known, but its mechanisms and pathways are not entirely comprehended. Some progresses have been achieved through many efforts and research. Consequently, new cellular and molecular mechanisms, diverse and conventional, are emerging. In listing some of those that will be the subject of our description and discussion, essential are the important roles of peripheral and infiltrated monocytes and clonotypic cells, alterations in the gut–brain axis, dysregulation of the apelinergic system, alterations in the endothelial glycocalyx of the endothelial component of neuronal vascular units, variations in expression of some genes and levels of the encoding molecules by the action of microRNAs (miRNAs), or other epigenetic factors and distinctive transcriptional factors, as well as the role of autophagy, ferroptosis, sex differences, and modifications in the circadian cycle. Such mechanisms can add significantly to understanding the complex etiological puzzle of neuroinflammation and ND. In addition, they could represent biomarkers and targets of ND, which is increasing in the elderly.

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