Biomarkers of Pediatric Brain Tumors

Russell, Mark; Young, Adam M. H.; Karri, Surya K.

doi:10.3389/fped.2013.00007

Cited by 23 publications

(21 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With its ability to probe tissue cellularity, the use of diffusion imaging with apparent diffusion coefficient (ADC) was also attempted to distinguish low-from high-grade brain tumors (9-13). However, its clinical acceptance is limited because of substantial overlap of ADC values among different tumor grades for both adult and pediatric patients (1,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). In addition, in some common locations (eg, the brain stem) of pediatric brain tumors, tumor grading D = 38.6 msec; duration of each diffusion gradient, d = 32.2 msec; field of view, 22 cm; section thickness, 5 mm; matrix size, 128 3 128; and imaging time, 3 minutes.…”

Section: Fundingmentioning

confidence: 99%

Differentiation of Low- and High-Grade Pediatric Brain Tumors with Highb-Value Diffusion-weighted MR Imaging and a Fractional Order Calculus Model

Sui¹,

Wang

Liu

et al. 2015

Radiology

View full text Add to dashboard Cite

).q RSNA, 2015 Purpose:To demonstrate that a new set of parameters (D, b, and m) from a fractional order calculus (FROC) diffusion model can be used to improve the accuracy of MR imaging for differentiating among low-and high-grade pediatric brain tumors. Materials and Methods:The institutional review board of the performing hospital approved this study, and written informed consent was obtained from the legal guardians of pediatric patients. Multi-b-value diffusion-weighted magnetic resonance (MR) imaging was performed in 67 pediatric patients with brain tumors. Diffusion coefficient D, fractional order parameter b (which correlates with tissue heterogeneity), and a microstructural quantity m were calculated by fitting the multi-b-value diffusion-weighted images to an FROC model. D, b, and m values were measured in solid tumor regions, as well as in normal-appearing gray matter as a control. These values were compared between the lowand high-grade tumor groups by using the Mann-Whitney U test. The performance of FROC parameters for differentiating among patient groups was evaluated with receiver operating characteristic (ROC) analysis. Results:None of the FROC parameters exhibited significant differences in normal-appearing gray matter (P  .24), but all showed a significant difference (P , . Conclusion:The FROC parameters can be used to differentiate between low-and high-grade pediatric brain tumor groups. The combination of FROC parameters or individual parameters may serve as in vivo, noninvasive, and quantitative imaging markers for classifying pediatric brain tumors.q RSNA, 2015

show abstract

Section: Fundingmentioning

confidence: 99%

Differentiation of Low- and High-Grade Pediatric Brain Tumors with Highb-Value Diffusion-weighted MR Imaging and a Fractional Order Calculus Model

Sui¹,

Wang

Liu

et al. 2015

Radiology

View full text Add to dashboard Cite

show abstract

“…As a result, tissue analysis for histone H3 mutations is now routinely performed for molecular diagnosis (5). In turn, multiple studies have evaluated biomarkers of various central nervous system tumors and their utility in diagnosis or longitudinal monitoring of response to treatment, including proteins and nucleic acids in the blood and CSF (43)(44)(45). While repeat tumor biopsy is often not clinically feasible, sampling of these liquid specimens to monitor Histone H3 mutant ctDNA or other potential disease biomarkers could prove valuable in guiding management.…”

Section: Discussionmentioning

confidence: 99%

Ventricular Cerebrospinal Fluid Sampling in Pediatric Diffuse Midline Glioma Patients: Institutional Experience and Review of the Literature

Stellpflug

Romanski

et al. 2020

Front. Pediatr.

View full text Add to dashboard Cite

Increasing evidence suggests that circulating biomarkers may serve diagnostic and longitudinal monitoring purposes in pediatric neuro-oncology. Mutant tumor DNA is detectable in the cerebrospinal fluid (CSF) of pediatric diffuse midline glioma (DMG) patients and quantity can reflect disease burden. CSF sampling ("liquid biopsy") via a CSF access device could therefore play a role in DMG management. Therefore, we set to evaluate the incidence of hydrocephalus (HCP) in DMG patients, and to characterize ventricular reservoir placement and access practices. Methods: A single institution retrospective review of DMG patients ≤21-years-old was performed (1984-2019). MEDLINE searches for reports of ventricular reservoir or shunt placement in DMG, and reservoir access for intraventricular chemotherapy (IVC) were performed. Results: At our institution, 62.6% of DMG patients (67/108) required intervention for HCP: 19.4% provided transient CSF access (ETV alone n = 3, EVD n = 8, unspecified n = 2), and 80.6% permanent CSF access (ETV + reservoir n = 13, shunt n = 41). Further, 22/34 patients with initially transient CSF devices required conversion to a permanent device. Five devices were revised for malfunction, one for infection. Seventeen articles cited HCP in 22 to 100% of DMG patients. IVC administration was described in 632 patients (seven articles), with 42 infectious and 63 non-infectious complications. Conclusions: Management of HCP is often necessary in children with DMG. Given the low rate of clinical risk associated with VAD placement and access, and the potential utility of longitudinal disease monitoring via CSF analysis, VAD placement could be considered in future clinical trials to guide DMG treatment.

show abstract

“…Methods are needed that highlight biomarkers with potential clinical utility in the diagnosis and treatment of the common types of primary pediatric brain tumors (15). In the present study, SNAP25 was less abundant in the tissue arrays and in our enrolled patients.…”

Section: Discussionmentioning

confidence: 99%

Detection of lower levels of SNAP25 using multiple microarray systems and its functional significance in medulloblastoma

Huang

Lee

Liu

et al. 2017

International Journal of Molecular Medicine

View full text Add to dashboard Cite

Medulloblastoma (MB) is the most common pediatric malignant brain tumor and patients with high-risk or recurrent MB respond poorly to current therapies, and have a higher related mortality. For this reason, potential molecules related to MB need be identified in order to develop targets for the development of novel therapeutics. In the present study, we compared MB microarray data obtained using different microarray systems and significant targets were selected by gene annotation and enrichment analysis. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the function 'vesicle' were identified and one of these proteins, synaptosomal-associated protein 25 (SNAP25), was found to have significantly lower expression levels in MB. In addition, SNAP25 was detected in a very low number of MB cells as shown by western blot analysis and immunohistochemical analyses of archived and formalin-fixed/paraffin-embedded human MB specimens. We found that SNAP25 altered the morphology and the chemotherapeutic effects of arabinofuranosyl cytidine (Ara-C) on SNAP25-expressing MB cells. On the whole, our data indicate that the expression of SNAP25 is crucial for dendrite formation and is associated with the effects of targeted chemotherapy. The detection of SNAP25 expression in MB cells may thus be essential for the chemotherapeutic application of Ara-C.

show abstract

Biomarkers of Pediatric Brain Tumors

Cited by 23 publications

References 38 publications

Differentiation of Low- and High-Grade Pediatric Brain Tumors with Highb-Value Diffusion-weighted MR Imaging and a Fractional Order Calculus Model

Differentiation of Low- and High-Grade Pediatric Brain Tumors with Highb-Value Diffusion-weighted MR Imaging and a Fractional Order Calculus Model

Ventricular Cerebrospinal Fluid Sampling in Pediatric Diffuse Midline Glioma Patients: Institutional Experience and Review of the Literature

Detection of lower levels of SNAP25 using multiple microarray systems and its functional significance in medulloblastoma

Contact Info

Product

Resources

About