Biomarkers of poly- and perfluoroalkyl substances (PFAS) in Sub-Arctic and Arctic communities in Canada

Exposure to Perfluoroalkyl Chemicals and Cardiovascular Disease: Experimental and Epidemiological Evidence

“…Many PFAS are highly resistant to degradation and represent persistent organic pollutants. Because of the huge number of applications and worldwide distribution of polluting sources, PFAS have been found even in the Arctic region (7). Due to their long half-life, PFAS can accumulate in the blood and tissues of living organisms through the food chain.…”

Plasma Concentrations of Perfluoroalkyl Acids and Their Determinants in Youth and Adults from Nunavik, Canada

“…Among pregnant or child-bearing aged women, the highest levels of PFNA were reported in Nunavik and Alaska Native communities followed by Greenland (AMAP, 2021c). PFNA was also elevated in Indigenous communities in the Northwestern Territories, Canada (Garcia-Barrios et al, 2021). Another recent study conducted in Greenland examined PFAAs concentrations in 177 mothers and fathers with mean ages of 34-37 years (Wielsøe et al, 2022).…”

Associations between Dietary Profiles and Perfluoroalkyl Acids in Inuit Youth and Adults

“…Exposure to PFOS in Nunavik decreased by 72 % compared to the first time they were measured in the Nunavik Inuit Health Survey in 2004; however PFOS concentrations remain 50 % more elevated compared to the Canadian general population (based on data from the Canadian Health Measures Survey 2016-2017; GM 3.3 μg/L) (Aker et al, 2021) Byrne et al, 2017), and PFNA was also elevated in Indigenous communities in the Northwestern Territories, Canada (Garcia-Barrios et al, 2021). This PFAAs exposure signature points to the unique exposure sources that may exist in northern latitudes versus other population in southern latitudes.…”