Biomarkers of renal function in prognostic stratification of patients with acute coronary syndrome

Přeček, Jan; Hutyra, Martin; Kováčik, František; Orság, Jiří; Táborský, Miloš

doi:10.1016/j.crvasa.2017.05.018

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…e H-FABP also detected the patients at enlarged risk for upcoming actions of cardiac diseases. J. Přeček et al [12] demonstrated a summary of patients with ACS of prognostic stratification according to baseline levels of renal function biomarkers. e authors of [13] provided a model with interpretable representation of long-term ECG recording and discovered the associations among all short heart rate patterns across the population of patients.…”

Section: Related Workmentioning

confidence: 99%

Decision Support System to Risk Stratification in the Acute Coronary Syndrome Using Fuzzy Logic

Nazir

et al. 2021

Scientific Programming

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Acute coronary syndrome (ACS) is a set of symptoms and signs which define a range of conditions related with the unexpected reduced blood flow to the heart. In ACS, the heart muscles cannot function properly due to the decrease of blood flow. Myocardial infarction (MI) is a condition which comes under the umbrella of acute coronary syndrome. The aim of risk stratification (RS) in ACS is to recognize patients at high risk of ischemic events. Yet, no investigative study is available to identify the patients at high risk. Therefore, to facilitate this process, it would be ideal to have a reliable and trustworthy method by the help of which the doctors can make early and easy decisions for the patient and for detecting the related disease. This research used the features of GRACE Score to RS in the ACS and presented decision support system (DSS). The concept of probabilistic approach has been used as a tool to model the identified features for decision-making (DM). This technique can be further used for DM purposes to RS in the ACS in healthcare. Furthermore, the result of the proposed method has proved closer and more reliable DM of patient and then eventually can be used for advice of medicine and rest accordingly by the doctors.

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Section: Related Workmentioning

confidence: 99%

Decision Support System to Risk Stratification in the Acute Coronary Syndrome Using Fuzzy Logic

Nazir

et al. 2021

Scientific Programming

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“…Its expression is up-regulated in AKI, but also during inflammation, renal and myocardial ischemia or infection [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Renal Functions and Prognosis Stratification in Chronic Heart Failure Patients and the Importance of Neutrophil Gelatinase-Associated Lipocalin

Lábr

Špinar

Pařenica

et al. 2018

Kidney Blood Press Res

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Background/Aims: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients. Methods: Data including age, gender, comorbidities and medical history of outpatients and hospitalized patients from Farmacology and NeuroHumoraL activation (FAR NHL) multicenter prospective registry comprising three Cardiological Centers in the Czech Republic were collected between 1st October 2014 and 30th November 2015. One-year follow-up data were collected in November 2016 in such a way that all patients had at least one-year data from the time of recruitment, but up to two years to the time of follow-up. One-year data were used for the whole set of patients while data up to 24 months were used with Kaplan-Meier‘s survival curves to analyse the patients‘ survival data. Blood samples were collected from the patients and basic parameters were evaluated in order to analyse Neutrophil gelatinase-associated lipocalin (NGAL) and plasma levels of N-terminal pro-brain natriuretic peptide (NT-ProBNP) using Lipocalin-2/NGAL Human ELISA kit (Bio Vendor, Czechia) and the Cobas E411 NT-proBNP Immunoassay kit (Roche Diagnostics, Indianapolis, IN, USA) respectively. Statistical analysis was further carried out to explain the level of significance of the evaluated parameters using Spearman Correlation, Mann Whitney or Kruskal-Wallis test and log-rank test. Results: Out of 547 patients from Farmacology and NeuroHumoraL activation (FAR NHL) multicenter prospective registry with available data on hospitalizations, mortality, biomarkers and one-year follow-up that were recorded, there were 439 males (80.3%) with a median age of 66 years. At least one-month stable patients with left ventricle ejection fraction (LV EF) under 50% were recorded. The etiology of heart failure was ischemic heart disease in 54%, dilated cardiomyopathy in 40% and others in 6%. 69% patients were in New York Heart Association functional class II. There were 76 events (13.9%; all-cause mortality, acute heart failure hospitalization, left ventricle assist device implantation and orthotopic heart transplant) in the first 365 days of follow-up. The area under the receiver operating characteristic curve was higher for NT-proBNP (0.77) than the creatinine (0.57), NGAL (0.55) or creatinine clearance (0.54). In multivariable analyses, NT-proBNP (P= 0.001) and NGAL (P = 0.004) were significant predictors of events. Subjects with NT-proBNP and NGAL above the cut off value (NT-proBNP 1,121 pg/ml, NGAL 80 ng/ml) survived without any event in 55.7%, subjects with NT-proBNP and NGAL unde...

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The Effect of Urea Nitrogen/Creatinin Ratio Level on in Hospital Mortality and One Year Mortality of Patients with ST Segment elevation Myocardial Infarction undergone thrombolytic therapy

Bodagh,

Yousefzadeh,

Ghanivash

et al. 2023

Preprint

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Introduction & Objective: Considering the increasing prevalence of ST-elevation myocardial infarction (STE-MI) and its health care costs and clinical consequences, as well as the fact that kidney problems are among the most common cases in these patients, treatment system and the evaluation of its functional improvement will be considered, Therefore, in the present study, we intend to investigate the effect of blood urea nitrogen to creatinin ratio (BUN/Cr) on in-hospital mortality (IHM) and one-year mortality of patients diagnosed with STEMI undergoing thrombolytic treatment. Materials and Methods: This descriptive cross-sectional descriptive study was conducted in in Shahid Madani, University of Medical Science, Tabriz, Iran in 2021. A list of patients diagnosed with STEMI and received thrombolytic treatments in 2017- 2019 were compiled. The file was included in the study and analyzed taking into account the inclusion and exclusion criteria. A checklist was used to collect the data. Data were analyzed using SPSS-15 software and descriptive and inferential statistics. Results: The results of the present study showed that blood BUN/Cr tolevel had no association with IHM and one-year mortality of STEMI patients who underwent thrombolytic treatment. There was also no association between the BUN/Cr ratio and in-hospital complications such as heart failure (HF) and cardiogenic shock (CS). Conclusion: we found that BUN/Cr ratio is not a reliable prognostic factor for mortality and hospital complications in STEMI patients.

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Biomarkers of renal function in prognostic stratification of patients with acute coronary syndrome

Cited by 3 publications

References 32 publications

Decision Support System to Risk Stratification in the Acute Coronary Syndrome Using Fuzzy Logic

Decision Support System to Risk Stratification in the Acute Coronary Syndrome Using Fuzzy Logic

Renal Functions and Prognosis Stratification in Chronic Heart Failure Patients and the Importance of Neutrophil Gelatinase-Associated Lipocalin

The Effect of Urea Nitrogen/Creatinin Ratio Level on in Hospital Mortality and One Year Mortality of Patients with ST Segment elevation Myocardial Infarction undergone thrombolytic therapy

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