Biomarkers of severity and chronification in chikungunya fever: a systematic review and meta-analysis

Ferreira, Andreia Silva; Baldoni, Nayara Ragi; Cardoso, Clareci Silva; Oliveira, Cláudia Di Lorenzo

doi:10.1590/s1678-9946202163016

Cited by 17 publications

(9 citation statements)

References 33 publications

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“…Studies suggested that the host's immune response is crucial in controlling CHIKV infection and that dysregulated responses can be damaging to the host, as is seen in severe and chronic cases [14,30]. Several evidences have demonstrated that persistent arthralgia could be the result of the host inflammatory response and increased production of inflammatory mediators, including IFN-α, IFN-γ, TNF-α, IL-1β, IL-6, IL-7, CXCL8/IL-8, IL-10, IL-12, IL-15, IL-17, IL-27, GM-CSF, CCL2/MCP-1, and CXCL10/IP10 [47].…”

Section: Discussionmentioning

confidence: 99%

Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection

et al. 2022

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Chikungunya virus (CHIKV) infection causes intense cytokine/chemokine inflammatory responses and debilitating joint pain. Indoleamine2,3–dioxygenase 1 (IDO-1) is an enzyme that initiates the tryptophan degradation that is important in initial host innate immune defense against infectious pathogens. Besides that, IDO-1 activation acts as a regulatory mechanism to prevent overactive host immune responses. In this study, we evaluated IDO-1 activity and cytokine/chemokine patterns in CHIKV patients. Higher IDO-1 (Kyn/Trp ratio) activation was observed during the early acute phase of CHIKV infection and declined in the chronic phase. Importantly, increased concentrations of Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), Interferon γ (IFN-γ), C-C motif chemokine ligand 2/Monocyte Chemoattractant Protein-1 (CCL2/MCP-1) and C-X-C motif chemokine ligand 10/Interferon Protein-10 (CXCL10/IP-10) were found in the acute phase of infection, while C-C motif chemokine ligand 4/Macrophage Inflammatory Protein 1 β (CCL4/MIP-1β) was found at increased concentrations in the chronic phase. Likewise, CHIKV patients with arthritis had significantly higher concentrations of CCL4/MIP-1β compared to patients without arthritis. Taken together, these data demonstrated increased IDO-1 activity, possibly exerting both antiviral effects and regulating exacerbated inflammatory responses. CCL4/MIP-1β may have an important role in the persistent inflammation and arthritic symptoms following chikungunya infection.

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Section: Discussionmentioning

confidence: 99%

Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection

et al. 2022

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“…In addition to the low incidence of CHIKV infection we hypothesized, the absence of active cases we reported which opposes the high seroprevalence of IgG antibodies could also support the hypothesis that CHIKV circulates in the population inducing light clinical manifestation which did not required medical consultation, making difficult to catch active cases. Increase or reduce levels of several biomarkers such as cytokines or coagulation factor (factor VII) have been associated with the severity of CHIKV infection [ 41 ]. In our study area co-endemic with helminth infections known to deeply modulate the host immune system to prevent immune-mediated worm ejection [ 42 ], we can hypothesize a possible interaction between the two infections to explain the low clinical expression of CHIKV infections we observed.…”

Section: Discussionmentioning

confidence: 99%

Molecular surveillance for dengue serotypes among the population living in Moyen-Ogooué province, Gabon; evidence of the presence of dengue serotype 1

Bikangui,

Parkouda,

et al. 2024

Virol J

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Background Despite dengue virus (DENV) outbreak in Gabon a decade ago, less is known on the potential circulation of DENV serotypes in the country. Previous studies conducted in some areas of the country, are limited to hospital-based surveys which reported the presence of some cases of serotype 2 and 3 seven years ago and more recently the serotype 1. As further investigation, we extend the survey to the community of Moyen Ogooué region with the aim to assess the presence of the dengue virus serotypes, additionally to characterize chikungunya (CHIKV) infection and describe the symptomatology associated with infections. Method A cross-sectional survey was conducted from April 2020 to March 2021. The study included participants of both sexes and any age one year and above, with fever or history of fever in the past seven days until blood collection. Eligible volunteers were clinically examined, and blood sample was collected for the detection of DENV and CHIKV using RT-qPCR. Positive samples were selected for the target sequencing. Results A total of 579 volunteers were included. Their mean age (SD) was 20 (20) years with 55% of them being female. Four cases of DENV infection were diagnosed giving a prevalence of 0.7% (95%CI: 0.2–1.8) in our cohort while no case of CHIKV was detected. The common symptoms and signs presented by the DENV cases included fatigue, arthralgia myalgia, cough, and loss of appetite. DENV-1was the only virus detected by RT-qPCR. Conclusion Our results confirm the presence of active dengue infection in the region, particularly DENV-1, and could suggest the decline of DENV-2 and DENV-3. Continuous surveillance remains paramount to comprehensively describe the extent of dengue serotypes distribution in the Moyen-Ogooué region of Gabon.

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“…Therefore, the diagnosis of the disease with an emphasis on the early prognosis of the neopterin can improve medical treatment in its initial phase, preventing the progression to its most severe form. Neopterin is expressed in the first days of the disease and the different concentrations of this marker may be useful to monitor the activation of the immune response [16,31]. Another study found higher values of CSF neopterin in patients with meningitis caused by viruses and bacteria compared to controls [13].…”

Section: Discussionmentioning

confidence: 99%

Neopterin and CXCL-10 in Cerebrospinal Fluid as Potential Biomarkers of Neuroinvasive Dengue and Chikungunya

et al. 2021

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Dengue (DENV) and chikungunya viruses (CHIKV) cause severe neurological complications, sometimes undiagnosed. Therefore, the use of more accessible neuroinflammatory biomarkers can be advantageous considering their diagnostic and prognostic potential for aggravated clinical outcomes. In this study, we aimed to evaluate neopterin and C-X-C motif chemokine ligand 10 (CXCL-10) in cerebrospinal fluid (CSF) for the diagnosis of neuroinvasive DENV and CHIKV. We analyzed the CSF of 66 patients with neurological disorders, comprising 12 neuroinvasive DENV/CHIKV, 20 inflammatory control (viral, bacterial, and fungal meningitis, and autoimmune disorders), and 24 noninflammatory control (cerebrovascular disease, dementia, neoplasm). There was no difference between the concentration of CSF neopterin in the neuroinvasive DENV/CHIKV and control groups. However, there was a significant difference in the CXCL-10 level when comparing the neuroinvasive DENV/CHIKV group and the non-inflammatory control (p < 0.05). Furthermore, we found a linear correlation between neopterin and CXCL-10 CSF levels in the three groups. For the DENV/CHIKV neuroinvasive diagnosis, the ROC curve showed the best cut-off values for CSF neopterin at 11.23 nmol/L (sensitivity of 67% and specificity of 63%), and for CSF CXCL-10 at 156.5 pg/mL (91.7% sensitivity and specificity). These results show that CXCL-10 in CSF represents an accurate neuroinflammatory biomarker that may contribute to neuroinvasive DENV/CHIKV diagnosis.

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Biomarkers of severity and chronification in chikungunya fever: a systematic review and meta-analysis

Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution License.

Cited by 17 publications

References 33 publications

Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection

Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection

Molecular surveillance for dengue serotypes among the population living in Moyen-Ogooué province, Gabon; evidence of the presence of dengue serotype 1

Neopterin and CXCL-10 in Cerebrospinal Fluid as Potential Biomarkers of Neuroinvasive Dengue and Chikungunya

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