Biomarkers of suicidal behaviors: A comprehensive critical review

Capuzzi, Enrico; Caldiroli, Alice; Capellazzi, Martina; Tagliabue, Ilaria; Buoli, Massimiliano; Clerici, Massimo

doi:10.1016/bs.acc.2019.11.005

Cited by 30 publications

(24 citation statements)

References 135 publications

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“…Biochemical and molecular investigations of blood and urine make a liquid biopsy that could suggest new approaches for prevention, monitoring, and diagnosis [ 17 ]. Biomarkers are conceptions driven to present a sweeping landscape of a specific human biological system [ 18 ]. These biomarkers include different molecules such as fluorescence in situ hybridization (FISH), nuclear matrix protein number 22 (NMP22), bladder tumor antigen (BTA stat, BTA TRAK), immunocyte/uCyt+, and cytokeratins (CK-18, CK-20, and CYFRA 21-1) which can be used as urinary tumor markers [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Aalami

Abdeahad

Mesgari

et al. 2021

BioMed Research International

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Aims. Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin (ANG) protein in patients’ urine with bladder neoplasm. Methods. We performed a systematic literature search using ScienceDirect, Web of Science, PubMed/MEDLINE, Scopus, Google Scholar, and Embase, up to 10th October 2020 databases. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.2.2 software calculated the pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (LR+), negative likelihood ratio (LR-), Q ∗ index, and summary receiver-operating characteristic (SROC) for the role of ANG as a urinary biomarker for BCa patients. Results. Four case-control studies were included with 656 participants (417 cases and 239 controls) in this meta-analysis. The pooled sensitivity of 0.71 (95% CI: 0.66–0.75), specificity of 0.78 (95% CI: 0.73–0.81), LR+ of 3.34 (95% CI: 2.02–5.53), LR- of 0.37 (95% CI: 0.32–0.44), DOR of 9.99 (95% CI: 4.69–21.28), and AUC of 0.789 and Q ∗ index of 0.726 demonstrate acceptable diagnostic precision of ANG in identifying BCa. Conclusion. This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients.

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Section: Introductionmentioning

confidence: 99%

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Aalami

Abdeahad

Mesgari

et al. 2021

BioMed Research International

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“…Furthermore, no robust evidence associates the severity of impulsivity with serum lipid profile 16 , partly due to the fact that other biological factors such as the amount of circulating neurosteroids 17 or severity of systemic inflammation 18 can both influence the cholesterol blood levels and the vulnerability to suicidal behaviors. In this regard recent models included neuroinflammation as an important factor associated with the vulnerability to impulsive behaviours including suicide 19 . Recent studies identified neutrophil-tolymphocyte ratio (NLR) as a measure of low-grade inflammation in different systemic diseases 20 as well as a potential biomarker related to the severity of psychiatric disorders and suicide 21 .…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, recent models included neuroinflammation as an important factor associated with the vulnerability to impulsive behaviors including suicide. 19 Recent studies identified neutrophil-tolymphocyte ratio (NLR) as a measure of low-grade inflammation in different systemic diseases 20 as well as a potential biomarker related to the severity of psychiatric disorders and suicide. 21 Specifically, a recent meta-analysis reported higher levels of NLR in subjects with bipolar disorder (BD) and major depressive disorder (MDD) than healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Exploring the role of serum lipid profile and neutrophil-to-lymphocyte ratio in violent suicide attempters: a cross sectional study

et al. 2020

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Background Suicidality is one of the most common complications of mental disorders, so that the identification of potential biomarkers may be relevant in clinical practice. To date, the role of serum lipids and neutrophil/lymphocyte ratio (NLR) has been explored albeit with conflicting results. To the best of our knowledge, no study has explored lipid levels concomitantly with NLR in relation to violent suicide attempts. Therefore, we aimed to investigate whether serum lipid levels and NLR might be associated with the violent method of suicide attempts. Methods The study group consisted of 163 inpatients who attempted suicide. Blood samples were collected at the beginning of hospitalization to measure total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein, very-low-density lipoprotein (VLDL), triglycerides, and NLR. Descriptive analyses of the total sample were performed. The included patients were divided into two groups according to violent/nonviolent method. Groups were compared in terms of lipid (MANCOVAs). Results Plasma levels of total cholesterol (F = 5.66; P = .02), LDL (F = 4.94; P = .03), VLDL (F = 5.66; P = .02), and NLR (F = 8.17; P < .01) resulted to be significantly lower in patients that used a violent method compared to patients who attempted suicide with a nonviolent method. Conclusions Low cholesterol, LDL, and VLDL levels as well as low NLR value were associated with a violent method of suicide attempt in patients with mental disorders. Further studies are needed to confirm these results.

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“…11 As a result, future research should concentrate on the missing biomarkers, such as Treg cytokines like IL-10 and TGF-β1, as well as Th-2 cytokines like IL-4, IL-5 and IL-13 (see also ESF 1 Table 1; column "what is missing in SB research"). Thirdly, this study did not include other potential variables regarding severity of SB, including lifetime SB 19 , staging of the major psychiatric disorders 13 , and stressful live events, including early lifetime trauma 4 . Further studies should also include those covariates.…”

Section: Discussionmentioning

confidence: 99%

Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis

Vasupanrajit

Jirakran

Tunvirachaisakul

et al. 2021

Preprint

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A meta-analysis showed a significant association between activated immune-inflammatory and nitro-oxidative (IO&NS) pathways and suicide attempts (SA). There is no data on whether suicidal ideation (SI) is accompanied by activated IO&NS pathways and whether there are differences between SA and SI. The current study searched PubMed, Google Scholar, and Web of Science, for articles published from inception until May 10, 2021, and systematically reviewed and meta-analyzed the association between recent SA/SI (< 3 months) and IO&NS biomarkers. We included studies which compared psychiatric patients with and without SA and SI and controls (either healthy controls or patients without SA or SI) and used meta-analysis (random-effect model with restricted maximum-likelihood) to delineate effect sizes with 95% confidence intervals (CI). Our search included 59 studies comprising 4.034 SA/SI cases and 12.377 controls. Patients with SA/SI showed activated IO&NS pathways (SMD: 0.299; CI: 0.200; 0.397) when compared to controls. The immune profiles were more strongly associated with SA than with SI, particularly when compared to healthy controls, as evidenced by activated IO&NS (SMD: 0.796; CI: 0.503; 1.089), immune (SMD: 1.409; CI: 0.637; 1.462), inflammatory (SMD: 1.200; CI: 0.584; 1.816), and neurotoxic (SMD: 0.904; CI: 0.431; 1.378) pathways. The effects sizes of the IO&NS, immune and inflammatory profiles were significantly greater in SA than in SI. In conclusion: increased neurotoxicity due to inflammation and nitro-oxidative stress and lowered neuroprotection explains at least in part why psychiatric patients show increased SA and SI. The IO&NS pathways are more pronounced in recent SA than in SI.

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Biomarkers of suicidal behaviors: A comprehensive critical review

Cited by 30 publications

References 135 publications

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Exploring the role of serum lipid profile and neutrophil-to-lymphocyte ratio in violent suicide attempters: a cross sectional study

Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis

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