2003
DOI: 10.1161/01.cir.0000089093.75585.98
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Biomarkers of Vascular Disease Linking Inflammation to Endothelial Activation

Abstract: A therosclerosis is regarded as a dynamic and progressive disease arising from the combination of endothelial dysfunction and inflammation. [1][2][3][4][5][6] This article is the second in a 2-part series examining emerging markers of inflammation and endothelial cell activation. The first article 7 provided a brief overview of the link between inflammation, endothelial dysfunction, and atherosclerosis and began the examination of emerging inflammatory mediators. This second article continues with an explorati… Show more

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Cited by 201 publications
(156 citation statements)
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“…The activation of adhesion molecules results in the expression of MCP-1, promoting the monocyte migration to the intima (32). The activity of MCP-1 also increases the platelet adhesion (33). The results of the present study suggested that AGEs significantly upregulated the expression levels of MCP-1 and ICAM-1 in HUVECs via the activation of NF-κB.…”
Section: Discussionsupporting
confidence: 54%
“…The activation of adhesion molecules results in the expression of MCP-1, promoting the monocyte migration to the intima (32). The activity of MCP-1 also increases the platelet adhesion (33). The results of the present study suggested that AGEs significantly upregulated the expression levels of MCP-1 and ICAM-1 in HUVECs via the activation of NF-κB.…”
Section: Discussionsupporting
confidence: 54%
“…For this purpose, 5ϫ10 6 PBMCs obtained by density gradient centrifugation on Ficoll-Paque (Amersham Biosciences) were plated on fibronectin-precoated, 6-well plates and cultivated in growth medium 199 (Gibco) containing 20% fetal calf serum and penicillin (100 U/mL)/streptomycin (100 g/mL, Gibco) for 48 hours. Nonadherent cells were then recollected, and 10 6 cells/well were replated onto fibronectin-coated, 24-wells plates (Nunc) and cultured in duplicate samples for 7 days in growth medium that was changed every 3 days.…”
Section: Cfu Assaymentioning
confidence: 99%
“…In brief, PBMCs were isolated by density gradient centrifugation on Ficoll-Paque. PBMCs (4ϫ10 6 /well) were plated on 24-well culture plates (Nunc) coated with fibronectin in 1 mL endothelial basal medium-2 supplemented with endothelial growth medium-2 single quots (both from Cambrex Bio Science) containing fetal bovine serum, hydrocortisone, human VEGF-A, human FGF-B, human epidermal growth factor, insulinlike growth factor-1, and ascorbic acid in appropriate amounts. 26 After 4 days, nonadherent cells were removed by washing twice with phosphate-buffered saline, and adherent cells were again incubated in 1 mL medium.…”
Section: Cac Culture Assaymentioning
confidence: 99%
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“…12 The LOX-1 receptor has been shown to be responsible for the oxidation of LDL cholesterol and to play an important role in adhesion molecule activation. 13 Aldosterone also has been shown to increase tissue ACE activity 14 and in some studies prevents angiotensin II-induced downregulation of the angiotensin II type 1 (AT 1 ) receptor. 15 These studies suggest a vicious cycle in which angiotensin II, through the AT 1 receptor, stimulates the production of aldosterone, which in turn leads to an increase in tissue ACE activity, a further increase in angiotensin II, and therefore a further increase in aldosterone levels.…”
Section: Role Of Aldosterone In Vascular Damage and Its Consequencesmentioning
confidence: 99%