Biomarkers of Vascular Integrity in Traumatic Brain Injury and Correlation with Cerebrovascular Reactivity

Gong, Yunhua; Amyot, Franck; Qu, Bao-Xi; Kenney, Kimbra; Moore, Carol; Bogoslovsky, Tanya; Mueller, Gregory P.; Silverman, Erika

doi:10.21767/2472-1646.100031

Cited by 3 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Serum lipase: was assayed by colometric kinetic assay method using (lipase-LS colometric DGMRE kit, Egyptian company for biotechnology, Obour city, Cairo, Egypt). Reference range of serum lipase: < 60 IU/L (Moss and Handerson, 1999) CT angiography protocol will be used for patients with suspected vascular injuries (Gong et al, 2017).…”

Section: Renal Function Testsmentioning

confidence: 99%

Clinical and Laboratory Evaluation of Blunt Trauma Patients for the Early Diagnosis of Intra-Abdominal Injuries

Zaki

Bilal

Matar

et al. 2021

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

View full text Add to dashboard Cite

Background: Blunt abdominal trauma is seen with increasing frequency in emergency rooms and is continuous to be associated with significant morbidity and mortality. Intra-abdominal injuries following blunt trauma are of great medico-legal importance to forensic experts. Aim:The study aimed to investigate the contribution of non-invasively and rapidly obtained clinical presentation and biochemical parameters in the early diagnosis of intra-abdominal (IA) injuries in blunt trauma patients, then develop a scoring system and investigate its clinical applicability as pre-test to determine whether abdominal CT should be performed during the diagnosis or not. This may help to decrease number of malpractice claims due to medical negligence. Methods and results: A prospective study was conducted on 30 adult patients with blunt abdominal trauma presented to Emergency department (ED) of Ain shams university hospitals (ASUHS). Patients were classified into two groups: group 1: adult patients with blunt abdominal trauma with normal CT abdomen. Group 2: adult patients with blunt abdominal trauma with abnormal CT abdomen. For every patient, demographic, trauma, and clinical data were collected. Laboratory parameters measured included blood hemoglobin level, liver enzymes, kidney function tests, pancreatic enzymes and finally CT abdomen was done. The mean age for the adult patients with blunt abdominal trauma was 34 ± 11 years. Male to female ratio was 2:1 with no significant importance. There was no significant difference between both groups of the study as regards aetiology and delay time of trauma and the most common cause of BAT was motor car accidents that compromised (36.7%) of all patients. There was no significant difference between both groups of study as regards abdominal symptoms and signs. Regarding vital signs, incidence of patients with high pulse rate per minute more than 100 bpm and high respiratory rate more than 20 brpm were highly significant in group II than group I. There was no significant difference between both groups regarding blood pressure. As regards the conscious level, there was significant difference between both groups of study. Hemoglobin level was significantly lower group II than group I with cutoff point level equal to or less than 9.8gm/dl. AST, ALT, urea, creatinine, amylase and lipase levels showed no significant difference between both groups. According to CT, the spleen was the most injured organ in blunt abdominal trauma patients (43.8%) followed by the liver 4 cases (25%). Conclusion: A scoring system could be done by the sum of points obtained from each parameter (Hb level, pulse rate, respiratory rate, and conscious level). The score points range from (0-4). It was found that the patients with score (0-2) were mainly with normal CT abdomen. On the other hand, patients with score (1-4) were mainly with positive CT findings. So, this scoring system can be used for the early prediction of the presence of IAIs in BAT patients and as a pretest for the need of CT. Recommendations: Blood hem...

show abstract

Section: Renal Function Testsmentioning

confidence: 99%

Clinical and Laboratory Evaluation of Blunt Trauma Patients for the Early Diagnosis of Intra-Abdominal Injuries

Zaki

Bilal

Matar

et al. 2021

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

View full text Add to dashboard Cite

show abstract

“…Another study also with MRI showed that individual sportrelated concussion patients demonstrated both quantitative and qualitative patientspecific alterations in VMR (p < 0.005) that correlated strongly with clinical findings and that persisted beyond clinical recovery up to 376 days [44]. Other authors demonstrated that a panel of plasma biomarkers (Ang-1/Ang-2, SAA, VEGF, P-selectin, and vWF) and assessment of VMR might be useful combination as predictive biomarkers for therapies designed to improve cerebrovascular function in patients after TBI with persistent PCS [45].…”

Section: Mtbi: Cerebral Vasomotor Reactivitymentioning

confidence: 88%

Transcranial Doppler (TCD): Role for Patients After Concussion

Razumovsky¹

2021

Neurosonology in Critical Care

View full text Add to dashboard Cite

Points 1. Reproducibility and non-invasive testing capabilities of TCD support studies for its use as a diagnostic tool for mild TBI and marker for recovery. 2. TCD criteria for cerebral blood flow velocity and pulsatility index might allow for the differentiation of patients who may undergo secondary neurologic deterioration after acute mTBI and allow physicians better define management strategies. 3. Current results support the use of TCD measured cerebrovascular reactivity as a non-expensive and easy implemented research tool for identifying altered neurophysiology and monitoring recovery in long-term effects of mTBI. 4. In patients after mTBI TCD testing of cerebral hemodynamics may reveal earlier signs of intracranial stenosis that could lead to treatment of post-concussive symptoms. 5. TCD as a non-invasive and simple procedure must be engaged in the management of mTBI patients and must be utilized as a quantitative screening test to detect cerebrovascular disease presence.

show abstract

“…Pharmacological inhibition of Tie2 receptor signaling in juvenile mice subjected to injury reversed the BBB-protective phenotype, therefore, providing a potential age-related mechanism through Tie2/angiopoietin signaling [220]. Interestingly, vascular integrity was assessed in plasma protein from human TBI patients which showed decreased Ang1 expression, as well as, Ang1/Ang2 ratio as compared to controls [221]. This pathway may represent an additional key predictive marker of vascular impairment in TBI.…”

Section: Age-dependent Responsesmentioning

confidence: 97%

Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury

Cash

Theus

2020

IJMS

178

119

View full text Add to dashboard Cite

Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United States with roughly two million TBIs occurring annually. Due to the spectrum of severity and heterogeneity in TBIs, investigation into the secondary injury is necessary in order to formulate an effective treatment. A mechanical consequence of trauma involves dysregulation of the blood–brain barrier (BBB) which contributes to secondary injury and exposure of peripheral components to the brain parenchyma. Recent studies have shed light on the mechanisms of BBB breakdown in TBI including novel intracellular signaling and cell–cell interactions within the BBB niche. The current review provides an overview of the BBB, novel detection methods for disruption, and the cellular and molecular mechanisms implicated in regulating its stability following TBI.

show abstract

Biomarkers of Vascular Integrity in Traumatic Brain Injury and Correlation with Cerebrovascular Reactivity

Cited by 3 publications

References 16 publications

Clinical and Laboratory Evaluation of Blunt Trauma Patients for the Early Diagnosis of Intra-Abdominal Injuries

Clinical and Laboratory Evaluation of Blunt Trauma Patients for the Early Diagnosis of Intra-Abdominal Injuries

Transcranial Doppler (TCD): Role for Patients After Concussion

Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury

Contact Info

Product

Resources

About