Biomarkers: Understanding, Progress, and Implications in the Perioperative Period

Abdelmalak, Basem; Cata, Juan P.

doi:10.1016/j.aan.2010.08.001

Advances in Anesthesia

2010

DOI: 10.1016/j.aan.2010.08.001

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Biomarkers: Understanding, Progress, and Implications in the Perioperative Period

Basem Abdelmalak

Juan P. Cata

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2020

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“…Ideal biochemical serum markers should be very specific and sensitive in central nervous system (CNS) injuries, and after the damage, they should only be released from the CNS tissues and mixed into the blood stream by passing through the BBB [11]. Different biochemical substances were investigated to find an spesific indicator of cerebral cell damage.…”

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Comparison of neuroprotective effect of isoflurane and sevoflurane on cerebral ischemia

Sayan

Erdem²,

Korfali

2020

The European Research Journal

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P atients undergoing intracranial surgery are at risk for cerebral ischemia. Therefore, the aim of neuro-anaesthetics is to provide adequate cerebral perfusion during surgery [1]. In patients with increased intracranial pressure (ICP), due to cerebral tumors it is accepted that volatile anaesthetic agents are effective in the protection of cerebral ischemia that may develop due to decrease in systolic arterial pressure (SAP) [2]. Isoflurane's cerebral protection mechanisms include reduction of cerebral metabolic rate (CMR) and metabolic suppression, inhibition of sympathetic activity, reduction of glutamate receptors which are prevent calcium flow, and suppression of excitotoxicity of calcium cascade [3]. It is thought that isoflurane may be secondary to direct vasodilatation or to reduction in CMR by the increase in cerebral blood flow (CBF) reduction [4]. Isoflurane has been reported to cause cerebral protection similar to barbiturates by depressing CMR, and it was shown that it reduce ceree

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mentioning

confidence: 99%

Comparison of neuroprotective effect of isoflurane and sevoflurane on cerebral ischemia

Sayan

Erdem²,

Korfali

2020

The European Research Journal

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show abstract

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Biomarkers: Understanding, Progress, and Implications in the Perioperative Period

Cited by 1 publication

References 173 publications

Comparison of neuroprotective effect of isoflurane and sevoflurane on cerebral ischemia

Comparison of neuroprotective effect of isoflurane and sevoflurane on cerebral ischemia

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