Biomaterial applications of silk fibroin electrospun nanofibres

Yükseloğlu, Sevhan; Sökmen, Nihal; Canoğlu, Suat

doi:10.1016/j.mee.2015.04.008

Cited by 35 publications

(22 citation statements)

References 56 publications

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“…Silk is an ancient and the only natural filament fiber which is used for thousands of years and for the year 2011, China (126 ktons), India (20.4 ktons), Viet Nam (7.05 ktons), Romania (2.1 ktons), Thailand (1.6 ktons), and Uzbekistan (1.2 ktons) are the six major silk producers in the world [155]. Silk is a fine, strong continuous fibroin filament produced by the larva of certain insects especially the cultured silkworms constructing their cocoons.…”

Section: Electrospinning Of Silk Fibroinmentioning

confidence: 99%

Chitin, Chitosan, and Silk Fibroin Electrospun Nanofibrous Scaffolds: A Prospective Approach for Regenerative Medicine

Singh

Dutta

2015

Springer Series on Polymer and Composite Materials

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Intensive studies have been done to a wide range of natural and synthetic polymeric scaffolds which have been done for the use of implantable and temporal devices in tissue engineering. Biodegradable and biocompatible scaffolds having a highly open porous structure with compatible mechanical strength are needed to provide an optimal microenvironment for cell proliferation, migration, differentiation, and guidance for cellular in growth at host tissue. One of the most abundantly available biopolymer chitins and its deacetylated derivatives is chitosan which is non-toxic and biodegradable. It has potential biomedical applications such as tissue engineering scaffolds, wound dressings, separation membranes, antibacterial coatings, stent coatings, and biosensors. Recent literature shows the use of chitin and chitosan in electrospinning to produce scaffolds with improved cytocompatibility, which could mimic the native extra-cellular matrix (ECM). Similarly, silk from the Bombyx mori silkworm, a protein-based natural fiber, having superior machinability, biocompatibility, biodegradation, and bioresorbability, has evolved as an important candidate for biomedical porous material. This chapter focuses on recent advancements made in chitin, chitosan, and silk fibroin-based electrospun nanofibrous scaffolds, emphasizing on tissue engineering for regenerative medicine.

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Section: Electrospinning Of Silk Fibroinmentioning

confidence: 99%

Chitin, Chitosan, and Silk Fibroin Electrospun Nanofibrous Scaffolds: A Prospective Approach for Regenerative Medicine

Singh

Dutta

2015

Springer Series on Polymer and Composite Materials

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“…Electrospinning represents a process for fabrication of polymer nano-fibers by using an electrostatically driven jet of polymer solution or polymer melts [1]. Since 1994, when this technology was put to practical use, electrospinning has been recognized for its ability to fabricate nano-and micro-fibers in different forms and of different morphologies [2]. The human extracellular matrix contains submicron fibers and the samples created by electrospinning can closely resemble that network, with a high-specific surface area, which is very important for many applications.…”

Section: Introductionmentioning

confidence: 99%

Customization of Electrospinning for Tissue Engineering

et al. 2018

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This paper deals with two electrospinning technologies: the melt electrospinning with a customized jet head, adapted from the fused deposition modeling (FDM) 3D printer, in comparison with the standard solution electrospinning, aiming at fabrication of tissue engineering scaffolds. The resulting fibers are compared. The influence of the collector properties on those of the fabricated scaffold is investigated. The resulting electrospun fibers exhibit different characteristics such as morphology and thickness, depending on the technology. The micro-fibers are produced by the melt electrospinning with an inbuilt 3D printer jet head, whereas the solution electrospinning has produced nano- and micro-fibers. The scaffolds fabricated on the rotating drum collector exhibit a more ordered structure as well as thinner fibers than those produced on the stationary plate collector. Further investigations should aim at fabrication of porous hollow fibers and tissue engineering scaffolds with controlled porosity and properties.

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“…The materials used for fabrication into skin scaffolds are usually biocompatible, which benefits the use in the human body and they can be both natural polymers (i.e. chitosan [9,12,15,16], cellulose acetate [17], collagen [18], gelatin [19][20][21] silk fibroin [5,22], silk sericin [23]) and synthetic polymers (i.e. polylactide [9,18], polyglycolide, poly (lactic acid)-co-glycolic acid [10,24], polycaprolactone [11,24,25], polyethylene glycol [26], poly(vinyl alcohol) [6,12,27]).…”

Section: Introductionmentioning

confidence: 99%

Novel 3D porous semi-IPN hydrogel scaffolds of silk sericin and poly(N-hydroxyethyl acrylamide) for dermal reconstruction

Ross¹,

Yooyod²,

Limpeanchob³

et al. 2017

Express Polym. Lett.

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In this work, a novel semi-interpenetrating polymer network (semi-IPN) hydrogel scaffold based on silk sericin (SS) and poly(N-hydroxyethyl acrylamide) (PHEA) was successfully fabricated via conventional free-radical polymerization. The porous structure of the scaffolds was introduced using a lyophilization technique and the effect of cross-linker (XL) on morphology, gelation time and physical properties of hydrogel scaffold was first studied. The results show that using low cross-linker content (0.125, 0.25 and 0.5 wt% XL) produced flexible scaffolds and appropriate gelation times for fabricating the scaffold. Therefore, the polymerization system with a constant percentage of XL at 0.5 wt% was chosen to study further the effect of SS on the physical properties and cell culture of the scaffolds. It was observed that the hydrogel scaffold of PHEA without SS (PHEA/SS-0) had no cell proliferation, whereas hydrogel scaffolds with SS enhanced cell viability when compared to the positive control. The sample of PHEA/SS at 1.25 wt% of SS and 0.5 wt% of cross-linker was the most suitable for HFF-1 cells to migrate and cell proliferation due to possessing a connective porous structure, along with silk sericin. The results proved that this novel porous semi-IPN hydrogel has the potential to be used as dermal reconstruction scaffold.

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Biomaterial applications of silk fibroin electrospun nanofibres

Cited by 35 publications

References 56 publications

Chitin, Chitosan, and Silk Fibroin Electrospun Nanofibrous Scaffolds: A Prospective Approach for Regenerative Medicine

Chitin, Chitosan, and Silk Fibroin Electrospun Nanofibrous Scaffolds: A Prospective Approach for Regenerative Medicine

Customization of Electrospinning for Tissue Engineering

Novel 3D porous semi-IPN hydrogel scaffolds of silk sericin and poly(N-hydroxyethyl acrylamide) for dermal reconstruction

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