Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches

Negrini, Nicola Contessi; Franchi, Alessandro; Danti, Serena

doi:10.3390/cancers15041201

Cancers

2023

DOI: 10.3390/cancers15041201

|View full text |Cite

Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches

Nicola Contessi Negrini

Alessandro Franchi

Serena Danti

Abstract: Cancers are a leading cause of death around the world, accounting for nearly 10 million deaths yearly [...]

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

SWI/SNF-Deficient Sinonasal Carcinomas: Multidisciplinary Research Perspectives

Danti,

Ricci,

Macchi

et al. 2023

Curr Otorhinolaryngol Rep

View full text Add to dashboard Cite

Purpose of Review An emerging subset of dismal sinonasal cancers are those characterized by the loss of a SWItch/Sucrose Non-Fermentable (SWI/SNF) complex unit, such as the SWI/SNF-related Matrix-associated Actin-dependent Regulator of Chromatin (SMARC), which includes two main subtypes: SMARCB1- and SMARCA4-deficient sinonasal carcinomas, ultimately leading to four distinct SWI/SNF-deficient sinonasal tumors. These cancers are rare entities and low treatment responsive malignancies. In fact, they are poorly differentiated and usually detected at a late stage, when invasion of facial and cranial regions had already occurred. Recent Findings From a histological standpoint, SWI/SNF-deficient sinonasal carcinomas belong to the group of sinonasal undifferentiated carcinomas (SNUC); however, their distinctive features disclose a special category for these cancers. The identification of biomarkers and signaling pathways has led to the development of emerging therapies, such as immunotherapy and personalized treatments. Finally, we report preliminary findings on 3D in vitro models of sinonasal cancers, as a multidisciplinary tool that could empower the understanding of SWI/SNF-deficient cancer biology. Summary Here, we review the current knowledge about histological and molecular features of SWI/SNF-deficient sinonasal cancers, with a focus on treatment options and multidisciplinary research perspectives. The possibility of studying SWI/SNF-deficient sinonasal tumors in-depth would be fostered by the establishment of tumor cell lines.

show abstract

SWI/SNF-Deficient Sinonasal Carcinomas: Multidisciplinary Research Perspectives

Danti,

Ricci,

Macchi

et al. 2023

Curr Otorhinolaryngol Rep

View full text Add to dashboard Cite

show abstract

Experimental Models of Sinonasal Tumors for Preclinical Testing of Candidate Targeted Therapies

Codina-Martínez,

Lorenzo-Guerra,

Cabal

et al. 2023

Curr Otorhinolaryngol Rep

View full text Add to dashboard Cite

Biomaterial-assisted organoid technology for disease modeling and drug screening

Shao,

Wang,

Jin

et al. 2024

Materials Today Bio

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Biomaterial-Assisted 3D In Vitro Tumor Models: From Organoid towards Cancer Tissue Engineering Approaches

Abstract: Cancers are a leading cause of death around the world, accounting for nearly 10 million deaths yearly [...]

Cited by 4 publications

References 17 publications

SWI/SNF-Deficient Sinonasal Carcinomas: Multidisciplinary Research Perspectives

SWI/SNF-Deficient Sinonasal Carcinomas: Multidisciplinary Research Perspectives

Experimental Models of Sinonasal Tumors for Preclinical Testing of Candidate Targeted Therapies

Biomaterial-assisted organoid technology for disease modeling and drug screening

Contact Info

Product

Resources

About