Biomaterial-assisted photoimmunotherapy for cancer

Chen, Muchao; Chen, Qian

doi:10.1039/d0bm01154a

Cited by 16 publications

(9 citation statements)

References 92 publications

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“…Accumulating studies have indicated that various treatment methods, such as chemotherapy [16,17], photodynamic therapy (PDT), photothermal therapy (PTT) [18][19][20] and chemodynamic therapy (CDT) [21,22], can both kill tumors and activate the immune system by releasing tumor-associated antigens (TAAs) to stimulate the host's specific immune response to cancer, thus assisting ICB therapy [23,24]. For example, PDT utilizes photosensitizers and light to convert oxygen into reactive oxygen species (ROS) [25,26], which can induce immunogenic cell death (ICD) in cancer cells by exposing and releasing damage-associated molecular patterns (DAMPs) and subsequently convert the immunosuppressive microenvironment ("cold" tumors) into an immuneactivated microenvironment ("hot" tumors) [27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Gene augmented nuclear-targeting sonodynamic therapy via Nrf2 pathway-based redox balance adjustment boosts peptide-based anti-PD-L1 therapy on colorectal cancer

et al. 2021

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Background Colorectal cancer is known to be resistant to immune checkpoint blockade (ICB) therapy. Sonodynamic therapy (SDT) has been reported to improve the efficacy of immunotherapy by inducing immunogenic cell death (ICD) of cancer. However, the SDT efficacy is extremely limited by Nrf2-based natural redox balance regulation pathway in cancer cells in response to the increased contents of reactive oxygen species (ROS). Nuclear-targeting strategy has shown unique advantages in tumor therapy by directly destroying the DNA. Thus it can be seen that Nrf2-siRNA augmented nuclear-targeting SDT could boost ICB therapy against colorectal cancer. Results The nuclear-targeting delivery system TIR@siRNA (TIR was the abbreviation of assembled TAT-IR780) with great gene carrier capacity and smaller diameter (< 60 nm) was designed to achieve the gene augmented nuclear-targeting SDT facilitating the anti-PD-L1 (programmed cell death-ligand-1) therapy against colorectal cancer. In CT26 cells, TIR@siRNA successfully delivered IR780 (the fluorescent dye used as sonosensitizer) into cell nucleus and Nrf2-siRNA into cytoplasm. Under US (utrasound) irradiation, TIR@siRNA notably increased the cytotoxicity and apoptosis-inducing activity of SDT through down-regulating the Nrf2, directly damaging the DNA, activating mitochondrial apoptotic pathway while remarkably inducing ICD of CT26 cells. In CT26 tumor-bearing mice, TIR@siRNA mediated gene enhanced nuclear-targeting SDT greatly inhibited tumor growth, noticeably increased the T cell infiltration and boosted DPPA-1 peptide-based anti-PD-L1 therapy to ablate the primary CT26 tumors and suppress the intestinal metastases. Conclusions All results demonstrate that TIR@siRNA under US irradiation can efficiently inhibit the tumor progression toward colorectal CT26 cancer in vitro and in vivo by its mediated gene augmented nuclear-targeting sonodynamic therapy. Through fully relieving the immunosuppressive microenvironment of colorectal cancer by this treatment, this nanoplatform provides a new synergistic strategy for enhancing the anti-PD-L1 therapy to ablate colorectal cancer and inhibit its metastasis. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Gene augmented nuclear-targeting sonodynamic therapy via Nrf2 pathway-based redox balance adjustment boosts peptide-based anti-PD-L1 therapy on colorectal cancer

et al. 2021

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“…In certain cases, biomaterials themselves can act as phototherapy agents, amplifying the antitumor immunity induced by phototherapy. 113 PDT is a treatment method utilizing light irradiation at photosensitizer-accumulated sites, leading to the generation of ROS to treat tumors. An important aspect of PDT is its ability to rapidly release tumor cell debris, thereby triggering immunogenicity and ameliorating tumor antigen presentation via APCs.…”

Section: Acs Biomaterialsmentioning

confidence: 99%

Recent Biomaterial-Assisted Approaches for Immunotherapeutic Inhibition of Cancer Recurrence

Mozafari,

Jahanbekam,

Ashrafi

et al. 2024

ACS Biomater. Sci. Eng.

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Biomaterials possess distinctive properties, notably their ability to encapsulate active biological products while providing biocompatible support. The immune system plays a vital role in preventing cancer recurrence, and there is considerable demand for an effective strategy to prevent cancer recurrence, necessitating effective strategies to address this concern. This review elucidates crucial cellular signaling pathways in cancer recurrence. Furthermore, it underscores the potential of biomaterial-based tools in averting or inhibiting cancer recurrence by modulating the immune system. Diverse biomaterials, including hydrogels, particles, films, microneedles, etc., exhibit promising capabilities in mitigating cancer recurrence. These materials are compelling candidates for cancer immunotherapy, offering in situ immunostimulatory activity through transdermal, implantable, and injectable devices. They function by reshaping the tumor microenvironment and impeding tumor growth by reducing immunosuppression. Biomaterials facilitate alterations in biodistribution, release kinetics, and colocalization of immunostimulatory agents, enhancing the safety and efficacy of therapy. Additionally, how the method addresses the limitations of other therapeutic approaches is discussed.

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“…261 If the responses are amplified, auxiliary methods such as immune checkpoint blockade (ICB) may also be available. 262 In this regard, different types of biomaterials have been served as photoabsorbers or sensitizing agents to improve the performance of the therapeutics as well as minimize the possible side effects of this new technique. For instance, the encapsulation of oligodeoxynucleotides inside chitosan-coated hollow copper sulfide (CuS) nanoparticles was an effective template as a photoabsorbent agent (Fig.…”

Section: Advanced Applications Of Polysaccharides In Biomedical Engin...mentioning

confidence: 99%

Polysaccharide-based nanocomposites for biomedical applications: a critical review

Shokrani

Sajadi

et al. 2022

Nanoscale Horiz.

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Biomaterial-assisted photoimmunotherapy for cancer

Abstract: The biomaterials have been well designed as photoabsorbing/sensitizing agents or effective carriers to enhance the photoimmunotherapeutic efficacy and evade their side effects.

Cited by 16 publications

References 92 publications

Gene augmented nuclear-targeting sonodynamic therapy via Nrf2 pathway-based redox balance adjustment boosts peptide-based anti-PD-L1 therapy on colorectal cancer

Gene augmented nuclear-targeting sonodynamic therapy via Nrf2 pathway-based redox balance adjustment boosts peptide-based anti-PD-L1 therapy on colorectal cancer

Recent Biomaterial-Assisted Approaches for Immunotherapeutic Inhibition of Cancer Recurrence

Polysaccharide-based nanocomposites for biomedical applications: a critical review

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