Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes

Qi, Boyang; Ding, Yang; Zhang, Ying; Kou, Longfa; Zhao, Ying-Zheng; Yao, Qing

doi:10.1039/d3bm01295f

Cited by 5 publications

(2 citation statements)

References 101 publications

(140 reference statements)

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“…Autologous bone grafting elicits vascularization, ensuring blood perfusion to the graft site and guaranteeing an ample nutritional supply, thereby enhancing the graft viability. The process of bone formation necessitates angiogenesis, a pivotal phenomenon in the preliminary phases of bone regeneration . Osteoblasts and osteoclasts are activated by the transformation of mesenchymal stem cells into vascular endothelial cells (VEGs).…”

Section: Resultsmentioning

confidence: 99%

“…The process of bone formation necessitates angiogenesis, a pivotal phenomenon in the preliminary phases of bone regeneration. 52 Osteoblasts and osteoclasts are activated by the transformation of mesenchymal stem cells into vascular endothelial cells (VEGs). Different vascular system cells release a vascular endothelial growth factor (VEGF).…”

Section: In Vitro Drug Release Kinetics Studiesmentioning

confidence: 99%

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Productizing Nano-Bioactive Glass-Based Bilayer Scaffolds: A Graft for Reconstruction of Mandibular and Femoral Bone Defects

Krishnamoorthy,

Purusothaman,

Subramanian

2024

ACS Appl. Mater. Interfaces

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This investigation aimed to construct a bilayer scaffold integrating alginate and gelatin with nanobioactive glass (BG), recognized for their efficacy in tissue regeneration and drug delivery. Scaffolds, namely, alginate/gelatin (AG), alginate-/actonel gelatin (AGD), alginate actenol/gelatin-45S5 BG (4AGD), and alginate-actonel/gelatin-59S BG (5AGD), were assembled using a cost-effective freeze-drying method, followed by detailed structural investigation via powder X-ray diffraction as well as morphological characterization using field emission scanning electron microscopy (FESEM). FESEM revealed a honeycomb-like morphology with distinct pore sizes for nutrient, oxygen, and drug transport. The scaffolds evidently exhibited hemocompatibility, high porosity, good swelling capacity, and biodegradability. In vitro studies demonstrated sustained drug release, particularly for scaffolds containing actonel. In vivo tests showed that the bilayer scaffold promoted new bone formation, surpassing the control group in bone area increase. The interaction of the scaffold with collagen and released ions improved the osteoblastic function and bone volume fraction. The findings suggest that this bilayer scaffold could be beneficial for treating critical-sized bone defects, especially in the mandibular and femoral regions.

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Section: Resultsmentioning

confidence: 99%

Section: In Vitro Drug Release Kinetics Studiesmentioning

confidence: 99%