Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface

Busscher, Henk J.; Mei, Henny C. van der; Subbiahdoss, Guruprakash; Jutte, Paul C.; Dungen, J.J.A.M. van den; Zaat, Sebastian A. J.; Schultz, Marcus J.; Grainger, David W.

doi:10.1126/scitranslmed.3004528

Cited by 623 publications

(559 citation statements)

References 96 publications

(70 reference statements)

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“…Although titanium meets the fundamental requirements for a successful implant biomaterial, it does not exhibit any obvious antiseptic qualities; thus, it is crucial to develop modified titanium surfaces with enhanced antimicrobial potential 6) . Various approaches have been reported to convert the surfaces of biomedical devices into antimicrobial surfaces and lately several reviews have been published that describe some of these approaches [7][8][9][10][11][12][13][14][15][16][17][18][19] . However, there has been no general review of this topic.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial dental implant functionalization strategies —A systematic review

Grischke

Eberhard

Stiesch

2016

Dental Materials Journal

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Section: Introductionmentioning

confidence: 99%

Antimicrobial dental implant functionalization strategies —A systematic review

Grischke

Eberhard

Stiesch

2016

Dental Materials Journal

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“…The so-called "race for the surface" between bacteria and host cells makes it therefore critical to eliminate or contain pathogens as early as possible [15,16] and there is a strong interest in developing surfaces that can prevent infection.…”

Section: Introductionmentioning

confidence: 99%

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

et al. 2016

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Due to their outstanding mechanical properties and excellent biocompatibility, zirconiatoughened alumina (ZTA) ceramics have become the gold standard in orthopedics for the fabrication of ceramic bearing components over the last decade. However, ZTA is bioinert, which hampers its implantation in direct contact with bone. Furthermore, periprosthetic joint infections are now the leading cause of failure for joint arthroplasty prostheses. To address both issues, an improved surface design is required: a controlled micro-and nano-roughness can promote osseointegration and limit bacterial adhesion whereas surface porosity allows loading and delivery of antibacterial compounds. In this work, we developed an integrated strategy aiming to provide both osseointegrative and antibacterial properties to ZTA surfaces. The microtopography was controlled by injection molding. Meanwhile a novel process involving the selective dissolution of zirconia (selective etching) was used to produce nano-roughness and interconnected nanoporosity. Potential utilization of the porosity for loading and delivery of antibiotic molecules was demonstrated, and the impact of selective etching on mechanical properties and hydrothermal stability was shown to be limited. The combination of injection molding and selective etching thus appears promising for fabricating a new generation of ZTA components implantable in direct contact with bone.3

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“…Additionally, the costs associated with the replacement of infected implants during revision surgery may triple the cost of the primary implant procedure [11]. Moreover, secondary implants and devices have a higher infection incidence because antibiotic resistant bacteria residing in the surrounding tissue can proliferate and colonize the recently implanted device [11].…”

Section: Introductionmentioning

confidence: 99%

The effects of surface properties on Escherichia coli adhesion are modulated by shear stress

Moreira

Araújo

Miranda

et al. 2014

Colloids and Surfaces B: Biointerfaces

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The adhesion of Escherichia coli to glass and polydimethylsiloxane (PDMS) at different flow rates (between 1 and 10 ml.s -1 ) was monitored in a parallel plate flow chamber in order to understand the effect of surface properties and hydrodynamic conditions on adhesion. Computational fluid dynamics was used to assess the applicability of this flow chamber in the simulation of the hydrodynamics of relevant biomedical systems. Wall shear stresses between 0.005 and 0.07 Pa were obtained and these are similar to those found in the circulatory, reproductive and urinary systems. Results demonstrate that E.coli adhesion to hydrophobic PDMS and hydrophilic glass surfaces is modulated by shear stress with surface properties having a stronger effect at the lower and highest flow rates tested and with negligible effects at intermediate flow rates. These findings suggest that when expensive materials or coatings are selected to produce biomedical devices, this choice should take into account the physiological hydrodynamic conditions that will occur during the utilization of those devices.

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Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface

Cited by 623 publications

References 96 publications

Antimicrobial dental implant functionalization strategies —A systematic review

Antimicrobial dental implant functionalization strategies —A systematic review

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

The effects of surface properties on Escherichia coli adhesion are modulated by shear stress

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