Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes

Gorbet, Maud; Sefton, Michael V.

doi:10.1016/j.biomaterials.2004.01.023

Cited by 1,200 publications

(915 citation statements)

References 209 publications

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“…This corresponds with the TAT analysis where we observed considerably less thrombin production in response to BIP‐CVC compared to the uncoated CVC. Thrombotic complications are a fatal outcome associated with the use of vascular devices 20. Our results from coagulation activation analysis suggest that BIP coating may potentially lower the risk of thrombotic complications.…”

Section: Discussionmentioning

confidence: 79%

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Improved ex vivo blood compatibility of central venous catheter with noble metal alloy coating

et al. 2015

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Central line associated bloodstream infections (CLABSIs) are a serious cause of morbidity and mortality induced by the use of central venous catheters (CVCs). Nobel metal alloy (NMA) coating is an advanced surface modification that prevents microbial adhesion and growth on catheters and thereby reduces the risk of infection. In vitro microbiological analyses have shown up to 90% reduction in microbial adhesion on coated CVC compared to uncoated ones. This study aimed to assess the blood compatibility of NMA‐coated CVC according to ISO 10993‐4. Hemolysis, thrombin–antithrombin (TAT) complex, platelet counts, fibrin deposition, and C3a and SC5b‐9 complement activation were analyzed in human blood exposed to the NMA‐coated and control CVCs using a Chandler‐loop model. NMA‐coated CVC did not induce hemolysis and fell in the “nonhemolytic” category according to ASTM F756‐00. Significantly lower amounts of TAT were generated and less fibrin was deposited on NMA‐coated CVC than on uncoated ones. Slightly higher platelet counts and lower complement markers were observed for NMA‐coated CVC compared to uncoated ones. These data suggest that the NMA‐coated CVC has better ex vivo blood compatibility compared to uncoated CVC. © 2015 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1359–1365, 2016.

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Section: Discussionmentioning

confidence: 79%

“…It has been found that contact with foreign materials activates platelets and subsequently leads to their removal from circulation 20. The magnitude of platelet counts remaining in circulation after exposure to medical devices reflects the blood compatibility of the biomaterial.…”

Section: Discussionmentioning

confidence: 99%

Improved ex vivo blood compatibility of central venous catheter with noble metal alloy coating

et al. 2015

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“…While biofouling usually starts with the nonspecific adsorption of proteins to the implanted biomaterial surface 34, 35, 36, 37. In the following study, we evaluated the antifouling capacity of our PNAGA‐PCBAA hydrogels by detecting the protein adsorption.…”

Section: Resultsmentioning

confidence: 99%

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Wang

Cui

et al. 2018

Advanced Science

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Recently, there has been a high expectation that high water absorbent hydrogels can be developed as an artificial vitreous body. However, the drawbacks associated with in vivo instability, biofouling, uncontrollable in situ reaction time, and injection‐induced precrosslinked fragmentation preclude their genuine use as vitreous substitutes. Here, a supramolecular binary copolymer hydrogel termed as PNAGA‐PCBAA by copolymerization of N‐acryloyl glycinamide (NAGA) and carboxybetaine acrylamide (CBAA) is prepared. This PNAGA‐PCBAA hydrogel physically crosslinked by dual amide hydrogen bonds of NAGA exhibits an ultralow solid content (1.6, 98.4 wt% water content), and shear‐thinning behavior, body temperature extrudability/self‐healability, rapid network recoverability, and very close key parameters (modulus, antifouling/antifibrosis, light transmittance, refractive index, ultrastability) to human vitreous body. It is demonstrated that the hydrogel can be readily injected by a 22G needle into the rabbits' eyes where the gelling network is rapidly recovered. After 16 weeks postoperation, the hydrogel acts as a very stable vitreous substitute without affecting the structure of soft tissues in eye, or eliciting adverse effects. This supramolecular binary copolymer hydrogel finds a broad application in ophthalmic fields as not only a self‐recoverable permanent vitreous substitute, but also transient intraocular filling for prevention of inner tissues in postsurgical eyes.

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“…Several authors have evaluated the chemical and morphological features of implant surfaces [5][6][7][8][9] and their interaction with all blood components [10,11].…”

Section: Introductionmentioning

confidence: 99%

The Surface Anodization of Titanium Dental Implants Improves Blood Clot Formation Followed by Osseointegration

et al. 2018

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Abstract:The anodization of titanium dental implant influences the biologic processes of osseointegration. 34 grit-blasted and acid-etched titanium specimens were used to evaluate microand nano-roughness (R a ), contact angle (θ) and blood clot extension (bce). 17 samples were anodized (test) while the remaining were used as control. The bce, was measured using 10 µL of human blood left in contact with titanium for 5 min at room temperature. The micro-and nano-scale R a were measured under CLSM and AFM, respectively, while the θ was analyzed using the sessile drop technique. The bone-implant contact (BIC) rate was measured on two narrow implants retrieved for fracture. bce was 42.5 (±22) for test and 26.6% (±13)% for control group (p = 0.049). The micro-R a was 6.0 (±1.5) for the test and 5.8 (±1.8) µm for control group (p > 0.05). The θ was 98.5 • (±18.7 • ) for test and 103 • (±15.2 • ) for control group (p > 0.05). The nano-R a was 286 (±40) for the test and 226 (±40) nm for control group (p < 0.05). The BIC rate was 52.5 (±2.1) for test and 34.5% (±2.1%) for control implant (p = 0.014). (Conclusions) The titanium anodized surface significantly increases blood clot retention, significantly increases nano-roughness, and favors osseointegration. When placing dental implants in poor bone quality sites or with immediate loading protocol anodized Ti6Al4V dental implants should be preferred.

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Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes

Cited by 1,200 publications

References 209 publications

Improved ex vivo blood compatibility of central venous catheter with noble metal alloy coating

Improved ex vivo blood compatibility of central venous catheter with noble metal alloy coating

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

The Surface Anodization of Titanium Dental Implants Improves Blood Clot Formation Followed by Osseointegration

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