Biomaterial Calcification: Mechanisms and Prevention

Munnelly, Amy; Schoen, Frederick J.; Vyavahare, Naren

doi:10.1007/978-1-4614-3942-4_14

Cited by 5 publications

(4 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electrochemical failures are mainly related to different forms of corrosion. Biological failures result from infection [254,255], inflammation [255,256,257,258], enzymatic degradation, calcification [259] and so forth. Failures may also result from synergistic effects, for example–SCC, corrosion fatigue (CF) and fretting corrosion [40,68,142].…”

Section: Implant Failure Retrieval and Failure Analysismentioning

confidence: 99%

Corrosion of Metallic Biomaterials: A Review

2019

View full text Add to dashboard Cite

Metallic biomaterials are used in medical devices in humans more than any other family of materials. The corrosion resistance of an implant material affects its functionality and durability and is a prime factor governing biocompatibility. The fundamental paradigm of metallic biomaterials, except biodegradable metals, has been “the more corrosion resistant, the more biocompatible.” The body environment is harsh and raises several challenges with respect to corrosion control. In this invited review paper, the body environment is analysed in detail and the possible effects of the corrosion of different biomaterials on biocompatibility are discussed. Then, the kinetics of corrosion, passivity, its breakdown and regeneration in vivo are conferred. Next, the mostly used metallic biomaterials and their corrosion performance are reviewed. These biomaterials include stainless steels, cobalt-chromium alloys, titanium and its alloys, Nitinol shape memory alloy, dental amalgams, gold, metallic glasses and biodegradable metals. Then, the principles of implant failure, retrieval and failure analysis are highlighted, followed by description of the most common corrosion processes in vivo. Finally, approaches to control the corrosion of metallic biomaterials are highlighted.

show abstract

Section: Implant Failure Retrieval and Failure Analysismentioning

confidence: 99%

Corrosion of Metallic Biomaterials: A Review

2019

View full text Add to dashboard Cite

show abstract

“…Calcification (formation of various types of calcium phosphates such as apatite) is a welldocumented event in various medical devices, especially in those used in the cardiovascular field [20,59,[519][520][521][522][523][524]. In fact, calcification is the leading macroscopic cause of failure for most prosthetic heart valves and blood pumps, limiting the functional lifetime of the device by the loss of elasticity in PU parts [7,20,519,[525][526][527].…”

Section: Calcificationmentioning

confidence: 99%

Degradation and stabilization of polyurethane elastomers

Xie

Zhang

Bryant

et al. 2019

Progress in Polymer Science

454

301

View full text Add to dashboard Cite

show abstract

“…For the purposes of further discussion, the novel tissue processing technique will be described as the technology platform and referred to as GLX [18]. Capping of functional groups such as aldehydes and free acids and reducing the remaining Schiff base sites reduces the potential sites for binding of calcium, phosphates, and immunogenic factors has been reported [19]. The glycerolisation treatment inhibits oxidation of the tissue, allowing for non-liquid storage and preservation of the structural integrity of the collagen matrix in the tissue valve.…”

Section: Study Devicementioning

confidence: 99%