Biomaterial engineering surface to control polymicrobial dental implant-related infections: focusing on disease modulating factors and coatings development

Malheiros, Samuel S.; Nagay, B; Bertolini, Martinna; Ávila, Érica Dorigatti de; Shibli, Jamil Awad; Souza, João Gabriel Silva; Barão, Valentim Adelino Ricardo

doi:10.1080/17434440.2023.2218547

Cited by 6 publications

(2 citation statements)

References 182 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…91 The complexity of surface topography stimulates the osteogenic outcomes in which the variation in the responses was due to shape, chemistry, and nanotexture. 92,93 For example, Narimatsu et al have reported good epithelial attachment and good connective tissue bonding for smooth surfaces and rough surfaces in vivo, respectively. 94 Furthermore, a 10-year study that evaluated the performance of dental implants with roughness on a submicron scale revealed a survival rate of 98.9% and healthy soft tissue in patients suffering from per-implant inflammation.…”

Section: Role Of Topography On Soft Tissue Integrationmentioning

confidence: 99%

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Safaei,

Mohammadi,

Beddu

et al. 2024

IJN

View full text Add to dashboard Cite

Metallic dental implants have been extensively used in clinical practice due to their superior mechanical properties, biocompatibility, and aesthetic outcomes. However, their integration with the surrounding soft tissue at the mucosal region remains challenging and can cause implant failure due to the peri-implant immune microenvironment. The soft tissue integration of dental implants can be ameliorated through different surface modifications. This review discussed and summarized the current knowledge of topography-mediated immune response and topography-mediated antibacterial activity in Ti dental implants which enhance soft tissue integration and their clinical performance. For example, nanopillar-like topographies such as spinules, and spikes showed effective antibacterial activity in human salivary biofilm which was due to the lethal stretching of bacterial membrane between the nanopillars. The key findings of this review were (I) cross-talk between surface nanotopography and soft tissue integration in which the surface nanotopography can guide the perpendicular orientation of collagen fibers into connective tissue which leads to the stability of soft tissue, (II) nanotubular array could shift the macrophage phenotype from pro-inflammatory (M1) to anti-inflammatory (M2) and manipulate the balance of osteogenesis/osteoclasia, and (III) surface nanotopography can provide specific sites for the loading of antibacterial agents and metallic nanoparticles of clinical interest functionalizing the implant surface. Silver-containing nanotubular topography significantly decreased the formation of fibrous encapsulation in per-implant soft tissue and showed synergistic antifungal and antibacterial properties. Although the Ti implants with surface nanotopography have shown promising in targeting soft tissue healing in vitro and in vivo through their immunomodulatory and antibacterial properties, however, long-term in vivo studies need to be conducted particularly in osteoporotic, and diabetic patients to ensure their desired performance with immunomodulatory and antibacterial properties. The optimization of product development is another challenging issue for its clinical translation, as the dental implant with surface nanotopography must endure implantation and operation inside the dental microenvironment. Finally, the sustainable release of metallic nanoparticles could be challenging to reduce cytotoxicity while augmenting the therapeutic effects.

show abstract

Section: Role Of Topography On Soft Tissue Integrationmentioning

confidence: 99%

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Safaei,

Mohammadi,

Beddu

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

“…The adjunctive application of antimicrobials, including chemical agents and antibiotics, is therefore considered a promising strategy to alleviate microbial burden ( Patil et al, 2022 ; López-Valverde et al, 2023 ). The past few years have witnessed a variety of antimicrobial agents for use in implant disinfection ( Malheiros et al, 2023 ). Nevertheless, due to heterogeneous microbial community organization, as well as existing extracellular polymeric substances and differentiated gene expression, dental biofilms are recalcitrant to most antibiotics and difficult to treat ( Kim et al, 2014 ; Wang et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Antibiofilm peptides enhance the corrosion resistance of titanium in the presence of Streptococcus mutans

Wang,

Yue,

Liu

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Titanium alloys have gained popularity in implant dentistry for the restoration of missing teeth and related hard tissues because of their biocompatibility and enhanced strength. However, titanium corrosion and infection caused by microbial biofilms remains a significant clinical challenge leading to implant failure. This study aimed to evaluate the effectiveness of antibiofilm peptides 1018 and DJK-5 on the corrosion resistance of titanium in the presence of Streptococcus mutans. Commercially pure titanium disks were prepared and used to form biofilms. The disks were randomly assigned to different treatment groups (exposed to S. mutans supplied with sucrose) including a positive control with untreated biofilms, peptides 1018 or DJK-5 at concentrations of 5 μg/mL or 10 μg/mL, and a negative control with no S. mutans. Dynamic biofilm growth and pH variation of all disks were measured after one or two treatment periods of 48 h. After incubation, the dead bacterial proportion, surface morphology, and electrochemical behaviors of the disks were determined. The results showed that peptides 1018 and DJK-5 exhibited significantly higher dead bacterial proportions than the positive control group in a concentration dependent manner (p < 0.01), as well as far less defects in microstructure. DJK-5 at 10 μg/mL killed 84.82% of biofilms and inhibited biofilm growth, preventing acidification due to S. mutans and maintaining a neutral pH. Potential polarization and electrochemical impedance spectroscopy data revealed that both peptides significantly reduced the corrosion and passive currents on titanium compared to titanium surfaces with untreated biofilms, and increased the resistance of the passive film (p < 0.05), with 10 μg/mL of DJK-5 achieving the greatest effect. These findings demonstrated that antibiofilm peptides are effective in promoting corrosion resistance of titanium against S. mutans, suggesting a promising strategy to enhance the stability of dental implants by endowing them with antibiofilm and anticorrosion properties.

show abstract

Progress in Designing Therapeutic Antimicrobial Hydrogels Targeting Implant‐associated Infections: Paving the Way for a Sustainable Platform Applied to Biomedical Devices

Dini,

Borges,

Malheiros

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Implantable biomedical devices have found widespread use in restoring lost functions or structures within the human body, but they face a significant challenge from microbial‐related infections, which often lead to implant failure. In this context, antimicrobial hydrogels emerge as a promising strategy for treating implant‐associated infections owing to their tunable physicochemical properties. However, the literature lacks a comprehensive analysis of antimicrobial hydrogels, encompassing their development, mechanisms, and effect on implant‐associated infections, mainly in light of existing in vitro, in vivo, and clinical evidence. Thus, this review addresses the strategies employed by existing studies to tailor hydrogel properties to meet the specific needs of each application. Furthermore, this comprehensive review critically appraises the development of antimicrobial hydrogels, with a particular focus on solving infections related to metallic orthopedic or dental implants. Then, preclinical and clinical studies centering on providing quantitative microbiological results associated with the application of antimicrobial hydrogels are systematically summarized. Overall, antimicrobial hydrogels benefit from the tunable properties of polymers and hold promise as an effective strategy for the local treatment of implant‐associated infections. However, future clinical investigations, grounded on robust evidence from in vitro and preclinical studies, are required to explore and validate new antimicrobial hydrogels for clinical use.

show abstract

Biomaterial engineering surface to control polymicrobial dental implant-related infections: focusing on disease modulating factors and coatings development

Cited by 6 publications

References 182 publications

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

Antibiofilm peptides enhance the corrosion resistance of titanium in the presence of Streptococcus mutans

Progress in Designing Therapeutic Antimicrobial Hydrogels Targeting Implant‐associated Infections: Paving the Way for a Sustainable Platform Applied to Biomedical Devices

Contact Info

Product

Resources

About