Biomaterial platforms offer capability of efficacious male contraceptives

Tropp, Joshua

doi:10.1557/s43577-022-00393-4

Cited by 1 publication

(2 citation statements)

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“…As a result, the acrosome of the sperm head, which is negatively charged, is destroyed, and the ovum's transparent zone is not dissolved, making it difficult for sperm to penetrate [ 91 ]. The injected RISUG is then dissolved at high pH by a second injection of 200 to 500 µL of DMSO or NaHCO 3 DMSO and excreted through the urethra [ 16 92 ]. Both DMSO and NaHCO 3 DMSO can dissolve SMA under alkaline conditions [ 93 ].…”

Section: Male Contraception In Research and Developmentmentioning

confidence: 99%

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Advances in Male Contraception: When Will the Novel Male Contraception be Available?

Kim,

So,

Heo

et al. 2024

World J Mens Health

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Many contraceptive methods have been developed over the years due to high demand. However, female contraceptive pills and devices do not work for all females due to health conditions and side effects. Also, the number of males who want to actively participate in family planning is gradually increasing. However, the only contraceptive options currently available to males are condoms and vasectomy. Therefore, many male contraceptive methods, including medication (hormonal and non-hormonal therapy) and mechanical methods, are under development. Reversibility, safety, persistence, degree of invasion, promptness, and the suppression of anti-sperm antibody formation are essential factors in the development of male contraceptive methods. In this paper, male contraceptive methods under development are reviewed according to those essential factors. Furthermore, the timeline for the availability of a new male contraception is discussed.

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Section: Male Contraception In Research and Developmentmentioning

confidence: 99%

“…In 2002, the test was stopped due to toxicity, but it was resumed in 2003 as an extended phase 3 trial [ 96 ]. The results have shown considerable potential, with administration through a single injection, complete reversibility, and 96.7% efficacy after 6 months [ 92 97 ].…”

Section: Male Contraception In Research and Developmentmentioning

confidence: 99%