Biomaterial scaffolds in maxillofacial bone tissue engineering: A review of recent advances

Huang, Xiangya; Lou, Yaxin; Duan, Yihong; Liu, He; Tian, Jun; Shen, Ya; Wei, Xi

doi:10.1016/j.bioactmat.2023.10.031

Cited by 22 publications

(9 citation statements)

References 166 publications

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“…Given that its stiffness is lower than Young's modulus of the tibia bone (18.01 GPa), this suggests that the bone implant is a potential candidate with the requisite lower stiffness required for osseointegration and bone regeneration (Figure 11) [94]. Huang et al [95] comprehensively reviewed several biomaterial scaffolds for applications of maxillofacial BTE. They explained the technical considerations of physical properties (shape, porous structure, microarchitecture and mechanical), biological properties and biomaterials (metals, polymers, ceramics, and composites) required for essential cell proliferation, angiogenesis, and osteogenesis [95].…”

Section: Simulation Of Mechanical Behaviour Of Bte Scaffolds Fem For ...mentioning

confidence: 99%

“…Huang et al [95] comprehensively reviewed several biomaterial scaffolds for applications of maxillofacial BTE. They explained the technical considerations of physical properties (shape, porous structure, microarchitecture and mechanical), biological properties and biomaterials (metals, polymers, ceramics, and composites) required for essential cell proliferation, angiogenesis, and osteogenesis [95]. Polymeric materials give more control over morphological parameters, biocompatibility, and biodegradation [96].…”

Section: Simulation Of Mechanical Behaviour Of Bte Scaffolds Fem For ...mentioning

confidence: 99%

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Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

N. Musthafa,

Walker,

Domagala

2024

Computation

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Three-dimensional porous scaffolds are substitutes for traditional bone grafts in bone tissue engineering (BTE) applications to restore and treat bone injuries and defects. The use of computational modelling is gaining momentum to predict the parameters involved in tissue healing and cell seeding procedures in perfusion bioreactors to reach the final goal of optimal bone tissue growth. Computational modelling based on finite element method (FEM) and computational fluid dynamics (CFD) are two standard methodologies utilised to investigate the equivalent mechanical properties of tissue scaffolds, as well as the flow characteristics inside the scaffolds, respectively. The success of a computational modelling simulation hinges on the selection of a relevant mathematical model with proper initial and boundary conditions. This review paper aims to provide insights to researchers regarding the selection of appropriate finite element (FE) models for different materials and CFD models for different flow regimes inside perfusion bioreactors. Thus, these FEM/CFD computational models may help to create efficient designs of scaffolds by predicting their structural properties and their haemodynamic responses prior to in vitro and in vivo tissue engineering (TE) applications.

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Section: Simulation Of Mechanical Behaviour Of Bte Scaffolds Fem For ...mentioning

confidence: 99%

Section: Simulation Of Mechanical Behaviour Of Bte Scaffolds Fem For ...mentioning

confidence: 99%

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

N. Musthafa,

Walker,

Domagala

2024

Computation

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“…20,21 An injectable hydrogel loaded with MgO exhibited excellent capabilities in promoting bone regeneration, including biomineralization and cytocompatibility with MC3T3-E1 cells in vitro. 22 To date, several bone scaffolds, 23 such as bioactive glass, 24 porous bioceramics, 25 nanofiber scaffolds, 26 and injectable materials, 27,28 have been developed in medical fields. Among these materials, injectable hydrogels loaded with boneinducing biomaterials have shown great potential.…”

Section: ■ Introductionmentioning

confidence: 99%

“…To date, several bone scaffolds, such as bioactive glass, porous bioceramics, nanofiber scaffolds, and injectable materials, , have been developed in medical fields. Among these materials, injectable hydrogels loaded with bone-inducing biomaterials have shown great potential.…”

Section: Introductionmentioning

confidence: 99%

Osteogenic Microenvironment Restoration around Dental Implants Induced by an Injectable MXene-Based Hydrogel

Chen,

Tao,

Zhang

et al. 2024

ACS Appl. Nano Mater.

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Peri-implantitis is an excessive inflammatory response induced by complex interactions between the bacteria, host immune system, and tissues around the dental implant. Alveolar bone resorption caused by peri-implantitis is a significant cause of implant failure. However, to restore the osteogenic microenvironment, a multifaceted therapeutic method that simultaneously encompasses anti-inflammatory and tissue regenerative strategies is indispensable. In this study, a temperature-sensitive hydrogel (FMXO) loaded with MXene and MgO was used to develop a multifunctional injectable MXene-based hydrogel. This hydrogel could release MXene and MgO in irregular bone defect areas in situ with no toxicity, either in vitro or in vivo. Our results showed that FMXO effectively inhibited the NF-κB signaling pathway in RAW264.7 cells and simultaneously upregulated the expression of ALP, Runx2, and OCN in bone marrow mesenchymal stromal cells (BMSCs). Therefore, FMXO exerted pharmacological effects on inflammation and bone regeneration. Moreover, we found that FMXO, when exposed to near-infrared (NIR) light, exhibited high efficacy against Porphyromonas gingivalis, Fusobacterium nucleatum, and their plaque microorganisms, which were considered the initiating factors of peri-implantitis. The multifunctionality of FMXO was also confirmed in an immediate peri-implant rat model in vivo, suggesting the great potential for peri-implantitis therapy in the dental clinic.

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“…Restoring a significant large bone or cartilage defect caused by illnesses, accidents, or trauma is one of the most challenging tasks in orthopedic therapeutic settings ( Agarwal et al, 2021 ; Hu et al, 2024 ; Huang et al, 2024 ; Martins et al, 2024 ). While the regeneration of orthopedic tissue is a gradual process, it is also a complicated one that necessitates a wide range of abilities and knowledge.…”

Section: Introductionmentioning

confidence: 99%

Bioprinting of gelatin-based materials for orthopedic application

Waidi,

Kariim,

Datta

2024

Front. Bioeng. Biotechnol.

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Bio-printed hydrogels have evolved as one of the best regenerative medicine and tissue engineering platforms due to their outstanding cell-friendly microenvironment. A correct hydrogel ink formulation is critical for creating desired scaffolds that have better fidelity after printing. Gelatin and its derivatives have sparked intense interest in various biomedical sectors because of their biocompatibility, biodegradability, ease of functionalization, and rapid gelling tendency. As a result, this report emphasizes the relevance of gelatin-based hydrogel in fabricating bio-printed scaffolds for orthopedic applications. Starting with what hydrogels and bio-printing are all about. We further summarized the different gelatin-based bio-printing techniques explored for orthopedic applications, including a few recent studies. We also discussed the suitability of gelatin as a biopolymer for both 3D and 4D printing materials. As extrusion is one of the most widely used techniques for bio-printing gelatin-based, we summarize the rheological features of gelatin-based bio-ink. Lastly, we also elaborate on the recent bio-printed gelatin-based studies for orthopedics applications, the potential clinical translation issues, and research possibilities.

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Biomaterial scaffolds in maxillofacial bone tissue engineering: A review of recent advances

Cited by 22 publications

References 166 publications

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

Osteogenic Microenvironment Restoration around Dental Implants Induced by an Injectable MXene-Based Hydrogel

Bioprinting of gelatin-based materials for orthopedic application

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