Biomaterials: A primer for surgeons

Binyamin, Gary; Shafi, Bilal M.; Mery, Carlos M.

doi:10.1053/j.sempedsurg.2006.07.007

Cited by 80 publications

(50 citation statements)

References 27 publications

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“…Thus, there is a large need for engineered replacements, including joints, heart valves, corneas and intraocular lenses made from a number of different biomaterials (Binyamin et al, 2006;Hench, 1980). A biomaterial can be defined as any substance, synthetic or natural in origin, that is used to replace or restore function to a body tissue or organ and maybe continuously or intermittently in contact with body fluids, cells, and tissues, and can be divided into ceramics, polymers, metals, and composites (Binyamin et al, 2006).…”

Section: Interaction Of Biomaterials With Cellsmentioning

confidence: 99%

“…A biomaterial can be defined as any substance, synthetic or natural in origin, that is used to replace or restore function to a body tissue or organ and maybe continuously or intermittently in contact with body fluids, cells, and tissues, and can be divided into ceramics, polymers, metals, and composites (Binyamin et al, 2006). Initially, research focused on producing biomaterials that did not elicit a biological response from the host, that is, a bioinert material.…”

Section: Interaction Of Biomaterials With Cellsmentioning

confidence: 99%

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Reprogramming and Carcinogenesis—Parallels and Distinctions

Wasik

Grabarek

Pantovic

et al. 2014

International Review of Cell and Molecular Biology

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Abbreviations: CDK -Cyclin-Dependent Kinase; CSC -cancer stem cells; DSB -double strand breaks ; ECM -extracellular matrix; ES cell -embryonic stem cell; GFP -green fluorescent protein; GSK3 -glycogen synthase kinase-3; HN -Hemagglutininneuraminidase; iPS -induced pluripotent stem cells; MSFs -myocardial scar fibroblasts; RB -Retinoblastoma protein; RGD -arginine-glycine-aspartic acid; RISC -RNA-induced silencing complex; Shc -Src homology 2 domain-containing.

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Section: Interaction Of Biomaterials With Cellsmentioning

confidence: 99%

Section: Interaction Of Biomaterials With Cellsmentioning

confidence: 99%

Reprogramming and Carcinogenesis—Parallels and Distinctions

Wasik

Grabarek

Pantovic

et al. 2014

International Review of Cell and Molecular Biology

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“…Currently, bone-implant materials can be classified into three different classes [15,16]. The first class is represented by bioinert materials (e.g., titanium, alumina or zirconia and ceramic and metal materials used in orthopedic or dental surgery, which are biocompatible and have almost no effect on their surrounding tissues [bone replacement]).…”

Section: Bone Repairmentioning

confidence: 99%

Inorganic Materials for Bone Repair or Replacement Applications

Hertz

Bruce

2007

Nanomedicine

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In recent years, excipient systems have been used increasingly in biomedicine in reconstructive and replacement surgery, as bone cements, drug-delivery vehicles and contrast agents. Particularly, interest has been growing in the development and application of controlled pore inorganic ceramic materials for use in bone-replacement and bone-repair roles and, in this context, attention has been focused on calcium-phosphate, bioactive glasses and SiO2- and TiO2-based materials. It has been shown that inorganic materials that most closely mimic bone structure and surface chemistry most closely function best in bone replacement/repair and, in particular, if a substance possesses a macroporous structure (pores and interconnections >100 microm diameter), then cell infiltration, bone growth and vascularization can all be promoted. The surface roughness and micro/mesoporosity of a material have also been observed to significantly influence its ability to promote apatite nucleation and cell attachment significantly. Pores (where present) can also be packed with pharmaceuticals and biomolecules (e.g., bone morphogenetic proteins [BMPs], which can stimulate bone formation). Finally, the most bio-efficient - in terms of collagen formation and apatite nucleation - materials are those that are able to provide soluble mineralizing species (Si, Ca, PO(4)) at their implant sites and/or are doped or have been surface-activated with specific functional groups. This article presents the context and latest advances in the field of bone-repair materials, especially with respect to the development of bioactive glasses and micro/mesoporous and macroporous inorganic scaffolds. It deals with the possible methods of preparing porous pure/doped or functionalized silicas or their composites, the studies that have been undertaken to evaluate their abilities to act as bone repair scaffolds and also presents future directions for work in that context.

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“…Hardy & Kendall (2005) have reported that particle diameters ranging from 25 to 100 mm are expected to follow the extracellular route, as their momentum is insufficient to breach the target barrier, due to the combination of relatively low density and small size. It has been recommended that stainless steel or polymer micro-particles should be used for extracellular routes, due to their biocompatibility and low cost (Disegi & Eschbach, 2000;Binyamin et al, 2006;Singh & Dahotre, 2007;Soliman, 2011;Sung et al, 2011).…”

Section: Micro-particle Materials and Sizementioning

confidence: 99%