Biomaterials and interface with bone

Abstract

In this paper, some examples from the literature or from my own experience will be given to illustrate the influence of surface topography and surface chemistry at the nano- and micro-scale on the cell and tissue response.

Development of Ti–Nb–Zr alloys with high elastic admissible strain for temporary orthopedic devices

“…The super- 85 ior cold-forming ability of b Ti alloys decreases the manufacturing 86 cost, thus creating an advantage for them in becoming commercial 87 products [4]. 88 The role of Ca-P formations on implant's surface is to accelerate 89 the assimilation of implant material and bone-tissue [21]. For 90 instance, on the surface of bio-inert Zirconia, calcium phosphate 91 formation enabling a chemical bond with the surrounding bone-92 tissue does not occur, it only ensures morphological fixation while 93 staying in the body [22].…”

On the interactions of human bone cells with Ti6Al4V thermally oxidized by means of laser shock processing

“…Thermal oxidation of Ti64 in a furnace operating at 500-700 °C in air results in the formation of an outer layer of rutile that increases the adhesion rates of bone-forming cells to the alloy [2,4,8]. Unlike thermal treatment in air, which only marginally modifies surface roughness, LP treatment generates a wavy surface at a scale that can be recognized by hOBs and hMSCs [24]. Due to the significant physicochemical changes experienced by the LP-treated alloy surface, we surmised that cell adhesion rates would be significantly affected.…”

Technology Foresight of New Orthopedic Prostheses: Trends in Innovation and Development in Health

“…Thus, in the convergence of nanotechnology with biotechnology, the focus shifts more towards the interaction between the nano components of the tissue and the nanomaterials themselves, with this subject being the target of considerable research yielding countless discoveries. Characteristics like the topographic surface of implants, their physicochemical properties, their porosity, mechanical properties, and cell-recognition mechanisms, amongst other features, simulate the normal physiology of bone tissue [6,14].…”