Biomaterials Based on Chitosan and Its Derivatives and Their Potential in Tissue Engineering and Other Biomedical Applications—A Review

Szulc, Marta; Lewandowska, Katarzyna

doi:10.3390/molecules28010247

Cited by 27 publications

(14 citation statements)

References 102 publications

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“…CH is able to stimulate the differentiation of multipotent mesenchymal progenitor cells and growth factor such as FGF and TGFβ1, increasing fibroblast proliferation. 2,7,18 Ca(OH) 2 been the material of choice for direct pulp capping. However, this material has some deficiencies.…”

Section: Discussionmentioning

confidence: 99%

Potency of the Combination of Chitosan and Hydroxyapatite on Angiogenesis and Fibroblast Cell Proliferation in Direct Pulp Capping of Rattus norvegicus

Sularsih,

Fransiska,

Salsabila

et al. 2024

Eur J Dent

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Objectives The aim of this research was to analyze expression of vascular endothelial growth factor (VEGF), blood vessels, and fibroblast cell proliferation in direct pulp capping treatment of Rattus norvegicus using a combination of chitosan and hydroxyapatite paste. Materials and Methods The samples were male R. norvegicus strains of Wistar rats, weighing 200 to 250 g and aged between 8 and 16 weeks. The occlusal surface of the molars of R. norvegicus was prepared with class I cavity and then perforated with the tip of an explorer. Sixty male R. Norvegicus rats were divided into the following: control group (KA) in which the cavity was filled with glass ionomer cement; control group (KB), in which the cavity was filled with Ca(OH)2; PA group, in which the cavity was filled with chitosan (CH); PB group, in which the cavity was filled with hydroxyapatite (HA); and PC group, in which the cavity was filled with chitosan and hydroxyapatite (CH-HA). Each group was divided into 3-, 7-, and 14-day observation groups. The mandibular bone of the molar was cut and histopathological examination was performed to analyze the blood vessels and fibroblast cell proliferation. Immunohistochemistry examination was done to examine the expression of VEGF. Statistical Analysis The data variation was analyzed with One Way Analysis of Variance (ANOVA) test and continued with multiple comparison Least Significant (LSD) test to determine the different pairs of group. Results Analysis of variance (ANOVA) showed a significant increase in the expression of VEGF, blood vessels, and fibroblast cell proliferations (p ≤ 0.05;), especially in the PC group compared to the other four groups. The least significant test (LSD) test showed significant differences between the groups on the expression of VEGF, blood vessels, and fibroblast cell proliferations. Conclusion The combination of chitosan and hydroxyapatite could promote healing of direct pulp capping treatment by increasing the expression of VEGF, blood vessel, and fibroblast cell proliferation.

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Section: Discussionmentioning

confidence: 99%

Potency of the Combination of Chitosan and Hydroxyapatite on Angiogenesis and Fibroblast Cell Proliferation in Direct Pulp Capping of Rattus norvegicus

Sularsih,

Fransiska,

Salsabila

et al. 2024

Eur J Dent

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“…However, chitosan by itself has a weak affinity to antibiotic drugs like levofloxacin; thus, its application as a DDS for levofloxacin is still limited. Chitosan by itself serves as a prospective DDS for variable types of therapeutics, such as antiviral drugs and materials for tissue engineering [ 11 , 12 , 13 ], as well as in combination with other DDS like niosomes and liposomes [ 9 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Conjugates of Chitosan with β-Cyclodextrins as Promising Carriers for the Delivery of Levofloxacin: Spectral and Microbiological Studies

Le-Deygen¹,

Skuredina²,

Mamaeva³

et al. 2023

Life

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In this work, we synthesized chitosan 5 kDa conjugates with β-cyclodextrins with various substituents as promising mucoadhesive carriers for the delivery of fluoroquinolones using the example of levofloxacin. The obtained conjugates were comprehensively characterized by spectral methods (UV-Vis, ATR-FTIR, 1H NMR, SEM). The physico-chemical properties of the complex formations were studied by IR, UV, and fluorescence spectroscopy. The dissociation constants of complexes with levofloxacin were determined. Complexation with conjugates provided four times slower drug release in comparison with plain CD and more than 20 times in comparison with the free drug. The antibacterial activity of the complexes was tested on model microorganisms Gram-negative bacteria Escherichia coli ATCC 25922 and Gram-positive Bacillus subtilis ATCC 6633. The complex with the conjugate demonstrated the same initial levofloxacin antibacterial activity but provided significant benefits, e.g., prolonged release.

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“…[1] These biomaterials play a key role as tissue replacement therapy during bone architectural damage in diseases like rheumatoid arthritis (RA). [2] Bone erosion and demineralization associated with RA are attributed to enhanced osteoclast activitycausing bone resorption-and inhibition of osteoblast activity-inhibiting new bone formation. These characteristics further attribute to bone fracture, leading to disability and thus impacting the quality of life.…”

Section: Introductionmentioning

confidence: 99%

QbD‐Based Fabrication of Biomimetic Hydroxyapatite Embedded Gelatin Nanoparticles for Localized Drug Delivery against Deteriorated Arthritic Joint Architecture

Ain,

Zeeshan,

Mazhar

et al. 2023

Macromolecular Bioscience

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Biomaterials such as nanohydroxyapatite and gelatin are widely explored to improve damaged joint architecture associated with rheumatoid arthritis (RA). Besides joint damage, RA is associated with inflammation of joints and cartilage, which potentiates the need for both bone nucleation and therapeutic intervention. For such purpose, a modified nanoprecipitation method is used herein to fabricate tofacitinib (Tofa)‐loaded nanohydroxyapatite (nHA) embedded gelatin (GLT) nanoparticles (NPs) (Tofa‐nHA‐GLT NPs). The quality by design (QbD) approach is chosen to assess the key parameters that determine the efficiency of the NPs, and are further optimized via Box–Behnken design of experiment. The particle size, polydispersity, zeta potential, and encapsulation efficiency (EE) of the prepared NPs are found to be 269 nm, 0.18, −20.5 mV, and 90.7%, respectively. Furthermore, the NPs have improved stability, skin permeability, and a sustained drug release pattern at pH 6.5 (arthritic joint pH). Moreover, rhodamine‐B loaded nHA‐GLT NPs demonstrates considerably higher cellular uptake by the murine‐derived macrophages than free rhodamine‐B solution. In vitro, cell‐based experiments confirm the good cell biocompatibility with insignificant toxicity. Thus, QbD‐based approach has successfully led to the development of Tofa‐nHA‐GLT NPs with the potential to target inflamed arthritic joint.

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Biomaterials Based on Chitosan and Its Derivatives and Their Potential in Tissue Engineering and Other Biomedical Applications—A Review

Cited by 27 publications

References 102 publications

Potency of the Combination of Chitosan and Hydroxyapatite on Angiogenesis and Fibroblast Cell Proliferation in Direct Pulp Capping of Rattus norvegicus

Potency of the Combination of Chitosan and Hydroxyapatite on Angiogenesis and Fibroblast Cell Proliferation in Direct Pulp Capping of Rattus norvegicus

Conjugates of Chitosan with β-Cyclodextrins as Promising Carriers for the Delivery of Levofloxacin: Spectral and Microbiological Studies

QbD‐Based Fabrication of Biomimetic Hydroxyapatite Embedded Gelatin Nanoparticles for Localized Drug Delivery against Deteriorated Arthritic Joint Architecture

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