2016
DOI: 10.1039/c5bm00358j
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Biomaterials-based strategies for salivary gland tissue regeneration

Abstract: The salivary gland is a complex, secretory tissue that produces saliva and maintains oral homeostasis. Radiation induced salivary gland atrophy, manifested as “dry mouth” or xerostomia, poses a significant clinical challenge. Tissue engineering recently has emerged as an alternative, long-term treatment strategy for xerostomia. In this review, we summarize recent efforts towards the development of functional and implantable salivary glands utilizing designed polymeric substrates or synthetic matrices/scaffolds… Show more

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Cited by 51 publications
(54 citation statements)
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References 93 publications
(167 reference statements)
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“… 1 , 2 Synthetic scaffolds must fulfil the functions of native ECM until cells and produce their own support structures to form an engineered tissue. 3 5 Hence, it is important to create an adequate cellular microenvironment with spatial variations of mechanical properties, cell-binding motifs, and morphogenic cues in hydrogel scaffolds. 6 8 Enzyme-mediated chemistry has been used to fabricate multi-layered hydrogels and core–shell particles.…”
Section: Introductionmentioning
confidence: 99%
“… 1 , 2 Synthetic scaffolds must fulfil the functions of native ECM until cells and produce their own support structures to form an engineered tissue. 3 5 Hence, it is important to create an adequate cellular microenvironment with spatial variations of mechanical properties, cell-binding motifs, and morphogenic cues in hydrogel scaffolds. 6 8 Enzyme-mediated chemistry has been used to fabricate multi-layered hydrogels and core–shell particles.…”
Section: Introductionmentioning
confidence: 99%
“…Our long-term goal is to engineer a functional, three-dimensional salivary gland for autologous implantation in patients suffering from xerostomia. [3]…”
Section: Introductionmentioning
confidence: 99%
“…[16] In this regard, HA-based hydrogels are particularly attractive as they can be tailored to represent the biochemical and physical characteristic of the desired tissue. [3, 17]…”
Section: Introductionmentioning
confidence: 99%
“…This often requires the supplementation with growth factors, proteins, vitamins, peptides, etc. 1 If administered systemically, the molecule of interest is largely metabolized by other organs and the amount reaching the target tissue may not be sufficient to induce the desired action. This may necessitate the use of larger multiple doses, which typically leads to side effects.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, a scaffold that continuously delivers the molecule of interest specifically to the target tissue is promising 2 . This is especially important for epithelial tissues because they are avascular and therefore, mainly nourished through molecules that diffuse out of the extracellular matrix 1 .…”
Section: Introductionmentioning
confidence: 99%