Biomaterials for drug delivery patches

Santos, Lúcia F.; Correia, Ilídio J.; Silva, Ana Sofia; Mano, João F.

doi:10.1016/j.ejps.2018.03.020

Cited by 118 publications

(64 citation statements)

References 134 publications

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“… 4 , 5 So, there is always a need to develop a drug-delivery system that could be able to burst release the drug as to achieve t max quickly for immediate action and thereafter release the drug in a precontrolled manner to maintain the plasma drug concentration for a longer duration of time. 3 In the last few decades, application of natural polymer in controlled drug-delivery system has gained a significant importance in medical and biomedical applications. 6 , 7 The various different polymers harnessed include xanthan gum 7 chitosan, 8 gellan gum, 9 locust bean gum, 10 guar gum, 11 etc.…”

Section: Introductionmentioning

confidence: 99%

Therapeutically Effective Controlled Release Formulation of Pirfenidone from Nontoxic Biocompatible Carboxymethyl Pullulan-Poly(vinyl alcohol) Interpenetrating Polymer Networks

et al. 2018

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The present study was conducted to develop therapeutically effective controlled release formulation of pirfenidone (PFD) and explore the possibility to reduce the total administered dose and dosing regimen. For this purpose, pH-sensitive biomaterial was prepared by inducing carboxymethyl group on pullulan by Williamson ether synthesis reaction, and further, interpenetrating polymeric network microspheres were prepared by glutaraldehyde-assisted water-in-oil (w/o) emulsion cross-linking method, which showed higher swelling ratio in acidic and basic pH. The formation of microspheres was confirmed by different spectral characterization techniques, and thermal kinetic study indicated the formation of thermally stable microspheres. Cell viability and biocompatibility studies on hepatocellular carcinoma (HepG2) cell showed the polymeric matrix to be biocompatible. In vitro dissolution of optimized formulation (F5) showed releases of 54.09 and 76.37% in 0.1 N HCl after 2 h and phosphate buffer (pH 6.8) up to 8 h, respectively. In vivo performances of prepared microsphere and marketed product of PFD were compared in rabbit. Tmax (time taken to reach peak plasma concentration) was found to be achieved at 0.83 h, compared to 0.5 h for Pirfenex with no significant difference complementing the immediate action, while area under curve was significantly greater for optimized formulation (9768 ± 1300 ng h/mL) compared to Pirfenex (4311 ± 110 ng h/mL), complementing the sustained action. In vivo pharmacokinetic study suggested that the prepared microsphere could be a potential candidate for therapeutically effective controlled delivery of PFD used in dyspnea and cough management due to idiopathic pulmonary fibrosis.

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Section: Introductionmentioning

confidence: 99%

Therapeutically Effective Controlled Release Formulation of Pirfenidone from Nontoxic Biocompatible Carboxymethyl Pullulan-Poly(vinyl alcohol) Interpenetrating Polymer Networks

et al. 2018

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“…Micropillar height had a notable effect on entrapment effectiveness, with the tallest pillars providing a greater volume of space for occupation by particles, mimicking the high-aspect-ratio hairs of honey bees (8). The entrapment effectiveness demonstrated in the current study is significantly higher-about five times more-than those presented by the currently available Food and Drug Administration-approved patches, which deliver drugs such as nicotine, lidocaine, and estradiol at doses around 5.1 mg/cm 2 and range in size from 3.5 to 280 cm 2 (15).…”

Section: Discussionmentioning

confidence: 69%

“…Drug patches with diverse designs have been developed, ranging from passive drug delivery with little/no permeation enhancement to complex systems that enable the delivery of small molecules and macromolecules (13). However, passivedelivery patches have been beset by problems limiting their application (14,15), with one potential solution being a higher drug content to improve transcutaneous fluxes (16). Herein, we show the development of a hierarchical biomimetic patch consisting of a polydimethylsiloxane (PDMS) micropatterned pillar structure and investigate the entrapment of polycaprolactone (PCL) microparticles.…”

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confidence: 99%

Physical immobilization of particles inspired by pollination

Santos

Silva

Correia

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Biomimetic systems often exhibit striking designs well adapted to specific functions that have been inspiring the development of new technologies. Herein, we explored the remarkable ability of honey bees to catch and release large quantities of pollen grains. Hair spacing and height on bees are crucial for their ability to mechanically fix pollen grains. Inspired by this, we proposed the concept of a micropatterned surface for microparticle entrapment, featuring high-aspect-ratio elastic micropillars spaced to mimic the hairy surface of bees. The hypothesis was validated by investigating the ability of polydimethylsiloxane microfabricated patches to fix microparticles. The geometrical arrangement, spacing, height, and flexibility of the fabricated micropillars, and the diameter of the microparticles, were investigated. Higher entrapment capability was found through the match between particle size and pillar spacing, being consistent with the observations that the diameter of pollen grains is similar to the spacing between hairs on bees' legs. Taller pillars permitted immobilization of higher quantities of particles, consistent with the high aspect ratio of bees' hairs. Our biomimetic surfaces were explored for their ability to fix solid microparticles for drug-release applications, using tetracycline hydrochloride as a model antibiotic. These surfaces allowed fixation of more than 20 mg/cm 2 of antibiotic, about five times higher dose than commercialized patches (5.1 mg/cm 2 ). Such bioinspired hairy surfaces could find applications in a variety of fields where dry fixation of high quantities of micrometer-sized objects are needed, including biomedicine, agriculture, biotechnology/chemical industry, and cleaning utensils. biomimetic | drug carriers | honey bee | patches | pollination

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“…Carboxymethyl cellulose (CMC) is a biodegradable, biocompatible polymer that is widely used in various industrial applications such as pharmaceutics, cosmetics, in biomedical applications as carriers for enzyme immobilization in biosensors, coating materials for drugs, and scaffolds for drug release . New drug delivery methods such as nanocarriers have been used in various applications, with nanosensors the focus of many research groups and pharmaceutical companies . Functioning of CMC for synthesis and preparation of nanomaterials depends on parameters such as concentration, adhesion, strength, releasing agent, water‐retaining agent, colloidal state, stabilizer, suspending agent, emulsifier and layer‐forming agent .…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of strontium nanoparticles self‐assembled in the presence of carboxymethyl cellulose: an in vivo imaging study

et al. 2019

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Carboxymethyl cellulose (CMC) is one of the main derivatives of cellulose and is used as a drug carrier for hydrophobic and hydrophilic drugs, imaging in vivo, and biological applications. Encapsulation is a technology in which target compounds are coated with wall compounds to form microcapsules. This study reports a new chemical processing wet method for precipitation and encapsulation of strontium nanoparticles (Sr NPs) within CMC structures using a sonochemical method. Preparation parameters such as microwave power and irradiation time as well as morphology and particle size of Sr NPs were also investigated. Products were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and atomic force microscopy. In this study, CMC was used as a biological stabilizer in a retentive phase to encapsulate Sr NPs. For the first time, Sr NPs were synthesized using CMC in a cost-effective, simple, fast, micellation-assisted, ultrasound method. Sr NPs were encapsulated in green capping agent structures of either 1%, 2% or 3% weight to provide an efficient optical nanostructure with a high yield at wavelengths 200-700 nm for use in in vivo imaging studies.

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Biomaterials for drug delivery patches

Cited by 118 publications

References 134 publications

Therapeutically Effective Controlled Release Formulation of Pirfenidone from Nontoxic Biocompatible Carboxymethyl Pullulan-Poly(vinyl alcohol) Interpenetrating Polymer Networks

Therapeutically Effective Controlled Release Formulation of Pirfenidone from Nontoxic Biocompatible Carboxymethyl Pullulan-Poly(vinyl alcohol) Interpenetrating Polymer Networks

Physical immobilization of particles inspired by pollination

Green synthesis of strontium nanoparticles self‐assembled in the presence of carboxymethyl cellulose: an in vivo imaging study

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